| URN | urn:agi-llid:6804 |
|---|---|
| Connectivity | 170 |
| Name | Stx1a |
| Description | syntaxin 1A (brain) |
| Notes | Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM] |
| Pathway | insulin secretion pathway |
|---|---|
| altered insulin secretion pathway | |
| altered insulin secretion pathway |
| GO Molecular Function | protein N-terminus binding |
|---|---|
| SNARE binding | |
| calcium-dependent protein binding | |
| glycoprotein binding | |
| protein domain specific binding | |
| protein binding, bridging | |
| SNAP receptor activity | |
| ATP-dependent protein binding | |
| myosin binding | |
| protein heterodimerization activity | |
| myosin head-neck binding | |
| calcium channel inhibitor activity |
| GO Cellular Component | extracellular region |
|---|---|
| synapse | |
| protein complex | |
| membrane | |
| plasma membrane | |
| neuron projection | |
| cytoplasmic vesicle | |
| synaptic vesicle membrane | |
| stored secretory granule | |
| actomyosin | |
| synaptosome | |
| cell junction | |
| synaptobrevin 2-SNAP-25-syntaxin-1a complex | |
| synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex | |
| integral to membrane |
| GO Biological Process | vesicle-mediated transport |
|---|---|
| transport | |
| positive regulation of neurotransmitter secretion | |
| exocytosis | |
| positive regulation of exocytosis | |
| synaptic transmission | |
| regulation of insulin secretion | |
| regulation of exocytosis | |
| calcium ion-dependent exocytosis | |
| synaptic vesicle docking involved in exocytosis | |
| response to gravity | |
| neurotransmitter transport | |
| intracellular protein transport |
| Ariadne Ontology | Vesicular secretory pathway |
|---|
| Group | Vesicular secretory pathway |
|---|---|
| extracellular region | |
| synapse | |
| vesicle-mediated transport | |
| transport | |
| positive regulation of neurotransmitter secretion | |
| exocytosis | |
| positive regulation of exocytosis | |
| synaptic transmission | |
| regulation of insulin secretion | |
| regulation of exocytosis | |
| calcium ion-dependent exocytosis | |
| synaptic vesicle docking involved in exocytosis | |
| response to gravity | |
| neurotransmitter transport | |
| intracellular protein transport | |
| protein N-terminus binding | |
| SNARE binding | |
| calcium-dependent protein binding | |
| glycoprotein binding | |
| protein domain specific binding | |
| protein binding, bridging | |
| SNAP receptor activity | |
| ATP-dependent protein binding | |
| myosin binding | |
| protein heterodimerization activity | |
| myosin head-neck binding | |
| calcium channel inhibitor activity | |
| protein complex | |
| membrane | |
| plasma membrane | |
| neuron projection | |
| cytoplasmic vesicle | |
| synaptic vesicle membrane | |
| stored secretory granule | |
| actomyosin | |
| synaptosome | |
| cell junction | |
| synaptobrevin 2-SNAP-25-syntaxin-1a complex | |
| synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex | |
| integral to membrane |
| MedScan ID | 6804 |
|---|
| Hugo ID | 11433 |
|---|
| Human chromosome position | 7q11.23 |
|---|
| LocusLink ID | 6804 |
|---|---|
| 20907 | |
| 116470 |
| Alias | STX1 |
|---|---|
| HPC-1 | |
| P35-1 | |
| SYN1A | |
| syntaxin-1A | |
| neuron-specific antigen HPC-1 | |
| syntaxin 1 a | |
| OTTMUSP00000017437 | |
| OTTMUSP00000039024 | |
| P35A | |
| synaptotagmin-associated 35 kDa protein | |
| Sap | |
| Neuron-specific antigen HPC I | |
| p35 I | |
| STX I | |
| STX1A | |
| Syn 1A | |
| Syn-1A | |
| syntaxin (SYN) 1A | |
| syntaxin 1/HPC-1 | |
| syntaxin 1A | |
| syntaxin 1A (brain) | |
| syntaxin 1 A (brain) | |
| syn1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 186590 |
|---|
| Mouse chromosome position | 5 |
|---|---|
| 5 G2 |
| GO ID | 0043008 |
|---|---|
| 0005484 | |
| 0000149 | |
| 0019855 | |
| 0048306 | |
| 0001948 | |
| 0017022 | |
| 0032028 | |
| 0047485 | |
| 0030674 | |
| 0019904 | |
| 0046982 | |
| 0017156 | |
| 0006886 | |
| 0006836 | |
| 0045921 | |
| 0001956 | |
| 0050796 | |
| 0009629 | |
| 0007268 | |
| 0016081 | |
| 0042641 | |
| 0030054 | |
| 0031410 | |
| 0005576 | |
| 0016021 | |
| 0043005 | |
| 0005886 | |
| 0043234 | |
| 0030141 | |
| 0045202 | |
| 0030672 | |
| 0070044 | |
| 0070032 | |
| 0019717 | |
| 0006887 | |
| 0017157 | |
| 0006810 | |
| 0016192 | |
| 0016020 | |
| 0005515 |
| Rat chromosome position | 12q12 |
|---|
| Swiss-Prot Accession | Q16623 |
|---|---|
| Q75ME0 | |
| Q7Z5K3 | |
| O35526 | |
| Q497P1 | |
| Q5D0A4 | |
| P32851 | |
| Q9QXG3 | |
| O15447 | |
| O15448 | |
| Q12936 | |
| Q75MD9 | |
| Q9BPZ6 |
| PIR ID | A38141 |
|---|
| Unigene ID | Hs.647024 |
|---|---|
| Mm.6225 | |
| Rn.9943 |
| KEGG ID | hsa:6804 |
|---|---|
| mmu:20907 | |
| rno:116470 |
| Swiss-Prot ID | STX1A_MOUSE |
|---|---|
| STX1A_RAT | |
| STX1A_HUMAN | |
| Q75ME0_HUMAN | |
| Q5D0A4_MOUSE | |
| Q497P1_MOUSE |
| Cell Localization | Cytoplasmic vesicle |
|---|---|
| secretory vesicle | |
| synaptic vesicle membrane | |
| Cell junction | |
| synapse | |
| synaptosome | |
| Secreted | |
| Golgi |
| IPI ID | IPI00131618 |
|---|---|
| IPI00324381 | |
| IPI00003370 | |
| IPI00221098 | |
| IPI00221099 | |
| IPI00792889 | |
| IPI00795234 | |
| IPI00885385 |
| Homologene ID | 37941 |
|---|
| RGD ID | 69430 |
|---|
| MGI ID | 109355 |
|---|