| Name | Gnas |
|---|---|
| Description | GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus |
| Notes | This gene encodes two alternated gene products, the extra-long form of the alpha-subunit of the Gs G protein (XLalphas) and Alex protein, which are derived from two different ORFs. The Alex interacts with the XL domain of the XLalphas and inhibits its adenylyl cyclase-stimulating function. The XLalphas may play a role in cholera toxin mediated induction of secretory vesicle formation. |
| Owner | Public |
| URN | urn:agi-llid:24896 |
| Connectivity | 9 |
| LocusLink ID | 24896 |
|---|
| GO ID | 0005525 |
|---|---|
| 0019001 | |
| 0042802 | |
| 0031852 | |
| 0000166 | |
| 0004871 | |
| 0007186 | |
| 0007189 | |
| 0051216 | |
| 0007191 | |
| 0048701 | |
| 0035116 | |
| 0001958 | |
| 0006112 | |
| 0045669 | |
| 0045672 | |
| 0040032 | |
| 0009791 | |
| 0042493 | |
| 0007165 | |
| 0001501 | |
| 0042995 | |
| 0005737 | |
| 0005834 | |
| 0044424 | |
| 0031224 | |
| 0005624 | |
| 0005886 | |
| 0042383 | |
| 0032588 | |
| 0031982 |
| Unigene ID | Rn.31 |
|---|---|
| Rn.127731 | |
| Rn.202435 |
| KEGG ID | rno:24896 |
|---|
| Alias | Gnas1 |
|---|---|
| Gnpas | |
| GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus | |
| GNAS complex locus | |
| guanine nucleotide binding protein alpha s | |
| guanine nucleotide binding protein, alpha stimulating | |
| guanine nucleotide-binding protein G-s, alpha subunit |
| Organism | Rattus norvegicus |
|---|
| Rat chromosome position | 3q42 |
|---|
| Pathway | protein kinase A (PKA) signaling pathway |
|---|---|
| vasopressin signaling pathway via receptor type 2 | |
| glucagon signaling pathway | |
| glucagon signaling pathway - Copy | |
| glucagon signaling pathway |
| RGD ID | 2716 |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| guanyl nucleotide binding | |
| GTP binding | |
| identical protein binding | |
| mu-type opioid receptor binding | |
| signal transducer activity |
| GO Cellular Component | cell projection |
|---|---|
| intracellular part | |
| membrane fraction | |
| cytoplasm | |
| trans-Golgi network membrane | |
| plasma membrane | |
| intrinsic to membrane | |
| heterotrimeric G-protein complex | |
| sarcolemma | |
| vesicle |
| GO Biological Process | positive regulation of osteoblast differentiation |
|---|---|
| positive regulation of osteoclast differentiation | |
| signal transduction | |
| G-protein coupled receptor protein signaling pathway | |
| dopamine receptor, adenylate cyclase activating pathway | |
| G-protein signaling, adenylate cyclase activating pathway | |
| energy reserve metabolic process | |
| post-embryonic development | |
| embryonic cranial skeleton morphogenesis | |
| embryonic hindlimb morphogenesis | |
| post-embryonic body morphogenesis | |
| skeletal development | |
| cartilage development | |
| endochondral ossification | |
| response to drug |
| Group | cell projection |
|---|---|
| intracellular part | |
| membrane fraction | |
| cytoplasm | |
| trans-Golgi network membrane | |
| plasma membrane | |
| intrinsic to membrane | |
| heterotrimeric G-protein complex | |
| sarcolemma | |
| vesicle | |
| nucleotide binding | |
| guanyl nucleotide binding | |
| GTP binding | |
| identical protein binding | |
| mu-type opioid receptor binding | |
| signal transducer activity | |
| positive regulation of osteoblast differentiation | |
| positive regulation of osteoclast differentiation | |
| signal transduction | |
| G-protein coupled receptor protein signaling pathway | |
| dopamine receptor, adenylate cyclase activating pathway | |
| G-protein signaling, adenylate cyclase activating pathway | |
| energy reserve metabolic process | |
| post-embryonic development | |
| embryonic cranial skeleton morphogenesis | |
| embryonic hindlimb morphogenesis | |
| post-embryonic body morphogenesis | |
| skeletal development | |
| cartilage development | |
| endochondral ossification | |
| response to drug |