| URN | urn:agi-llid:6804 |
|---|---|
| Total Entities | 0 |
| Connectivity | 339 |
| Name | Stx1a |
| Description | syntaxin 1A (brain) |
| Notes | Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM] |
| Ariadne Ontology | Vesicular secretory pathway |
|---|---|
| Secreted proteins |
| GO Molecular Function | calcium-dependent protein binding |
|---|---|
| glycoprotein binding | |
| SNARE binding | |
| ATP-dependent protein binding | |
| SNAP receptor activity | |
| protein binding, bridging | |
| protein N-terminus binding | |
| protein domain specific binding | |
| myosin binding | |
| myosin head-neck binding | |
| protein heterodimerization activity | |
| calcium channel inhibitor activity |
| GO Cellular Component | cell junction |
|---|---|
| membrane | |
| extracellular region | |
| synapse | |
| synaptic vesicle membrane | |
| actomyosin | |
| SNARE complex | |
| integral to membrane | |
| synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex | |
| synaptobrevin 2-SNAP-25-syntaxin-1a complex | |
| protein complex | |
| plasma membrane | |
| intracellular organelle | |
| cytoplasmic vesicle | |
| secretory granule | |
| synaptic vesicle | |
| neuron projection |
| GO Biological Process | synaptic transmission |
|---|---|
| positive regulation of neurotransmitter secretion | |
| regulation of insulin secretion | |
| positive regulation of exocytosis | |
| regulation of exocytosis | |
| glutamate secretion | |
| neurotransmitter secretion | |
| exocytosis | |
| calcium ion-dependent exocytosis | |
| energy reserve metabolic process | |
| synaptic vesicle docking involved in exocytosis | |
| response to gravity | |
| transport | |
| neurotransmitter transport | |
| vesicle-mediated transport | |
| intracellular protein transport | |
| small molecule metabolic process |
| Pathway | Exocytosis |
|---|---|
| altered insulin secretion pathway | |
| insulin secretion pathway | |
| altered insulin secretion pathway | |
| insulin secretion pathway | |
| altered insulin secretion pathway | |
| insulin secretion pathway | |
| altered insulin secretion pathway |
| Group | Vesicular secretory pathway |
|---|---|
| synaptic transmission | |
| positive regulation of neurotransmitter secretion | |
| regulation of insulin secretion | |
| positive regulation of exocytosis | |
| regulation of exocytosis | |
| glutamate secretion | |
| neurotransmitter secretion | |
| exocytosis | |
| calcium ion-dependent exocytosis | |
| energy reserve metabolic process | |
| synaptic vesicle docking involved in exocytosis | |
| response to gravity | |
| transport | |
| neurotransmitter transport | |
| vesicle-mediated transport | |
| intracellular protein transport | |
| small molecule metabolic process | |
| calcium-dependent protein binding | |
| glycoprotein binding | |
| SNARE binding | |
| ATP-dependent protein binding | |
| SNAP receptor activity | |
| protein binding, bridging | |
| protein N-terminus binding | |
| protein domain specific binding | |
| myosin binding | |
| myosin head-neck binding | |
| protein heterodimerization activity | |
| calcium channel inhibitor activity | |
| cell junction | |
| membrane | |
| extracellular region | |
| synapse | |
| synaptic vesicle membrane | |
| actomyosin | |
| SNARE complex | |
| integral to membrane | |
| synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex | |
| synaptobrevin 2-SNAP-25-syntaxin-1a complex | |
| protein complex | |
| plasma membrane | |
| intracellular organelle | |
| cytoplasmic vesicle | |
| secretory granule | |
| synaptic vesicle | |
| neuron projection | |
| Secreted proteins |
| MedScan ID | 6804 |
|---|---|
| 649357 |
| Hugo ID | 11433 |
|---|
| Human chromosome position | 7q11.23 |
|---|
| LocusLink ID | 6804 |
|---|---|
| 20907 | |
| 116470 | |
| 100360064 |
| Alias | STX1 |
|---|---|
| HPC-1 | |
| P35-1 | |
| SYN1A | |
| syntaxin-1A | |
| neuron-specific antigen HPC-1 | |
| syntaxin 1 a | |
| P35A | |
| synaptotagmin-associated 35 kDa protein | |
| Sap | |
| p35 I | |
| syntaxin 1A (brain) | |
| syntaxin 1A | |
| syntaxin (SYN) 1A | |
| Syn-1A | |
| Syn 1A | |
| STX1A | |
| STX I | |
| syntaxin 1/HPC-1 | |
| OTTMUSP00000039024 | |
| Neuron-specific antigen HPC I | |
| OTTMUSP00000017437 | |
| LOC100360064 | |
| syntaxin 1 A (brain) | |
| syn1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 186590 |
|---|
| Unigene ID | Hs.647024 |
|---|---|
| Mm.6225 | |
| Rn.9943 |
| KEGG ID | hsa:6804 |
|---|---|
| mmu:20907 | |
| rno:116470 |
| Swiss-Prot Accession | Q16623 |
|---|---|
| Q75ME0 | |
| O35526 | |
| Q497P1 | |
| P32851 | |
| O15447 | |
| O15448 | |
| Q12936 | |
| Q75MD9 | |
| Q9BPZ6 | |
| Q7Z5K3 | |
| Q5D0A4 | |
| Q9QXG3 |
| GO ID | 0043008 |
|---|---|
| 0005484 | |
| 0000149 | |
| 0019855 | |
| 0048306 | |
| 0001948 | |
| 0032028 | |
| 0047485 | |
| 0030674 | |
| 0019904 | |
| 0046982 | |
| 0017156 | |
| 0006112 | |
| 0014047 | |
| 0006886 | |
| 0007269 | |
| 0045921 | |
| 0001956 | |
| 0050796 | |
| 0009629 | |
| 0044281 | |
| 0007268 | |
| 0016081 | |
| 0031201 | |
| 0042641 | |
| 0030054 | |
| 0005576 | |
| 0016021 | |
| 0043005 | |
| 0005886 | |
| 0030141 | |
| 0030672 | |
| 0070044 | |
| 0070032 | |
| 0017022 | |
| 0006887 | |
| 0006836 | |
| 0017157 | |
| 0006810 | |
| 0016192 | |
| 0031410 | |
| 0043229 | |
| 0016020 | |
| 0043234 | |
| 0045202 | |
| 0008021 | |
| 0019717 | |
| 0005515 |
| PIR ID | A38141 |
|---|
| Swiss-Prot ID | STX1A_MOUSE |
|---|---|
| STX1A_RAT | |
| STX1A_HUMAN | |
| Q75ME0_HUMAN | |
| Q5D0A4_MOUSE | |
| Q497P1_MOUSE |
| Cell Localization | Cytoplasmic vesicle |
|---|---|
| secretory vesicle | |
| synaptic vesicle membrane | |
| Cell junction | |
| synapse | |
| synaptosome | |
| Secreted | |
| Golgi |
| IPI ID | IPI00131618 |
|---|---|
| IPI00324381 | |
| IPI00003370 | |
| IPI00221098 | |
| IPI00221099 | |
| IPI00792889 | |
| IPI00795234 | |
| IPI00885385 |
| Mouse chromosome position | 5 |
|---|---|
| 5 G2 |
| Rat chromosome position | 12q12 |
|---|
| Homologene ID | 37941 |
|---|
| MGI ID | 109355 |
|---|
| RGD ID | 69430 |
|---|
| Primary Cell Localization | Golgi |
|---|