| URN | urn:agi-llid:6844 |
|---|---|
| Total Entities | 0 |
| Connectivity | 267 |
| Name | Vamp2 |
| Description | vesicle-associated membrane protein 2 (synaptobrevin 2) |
| Notes | The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. |
| Ariadne Ontology | Endosomal recycling |
|---|---|
| Vesicular secretory pathway | |
| Secreted proteins |
| GO Molecular Function | protein complex binding |
|---|---|
| calmodulin binding | |
| SNARE binding | |
| protein C-terminus binding | |
| syntaxin binding | |
| syntaxin-1 binding | |
| myosin binding | |
| phospholipid binding |
| GO Cellular Component | cell junction |
|---|---|
| membrane | |
| synapse | |
| secretory granule membrane | |
| endocytic vesicle membrane | |
| zymogen granule membrane | |
| clathrin-sculpted glutamate transport vesicle membrane | |
| clathrin-sculpted monoamine transport vesicle membrane | |
| synaptic vesicle membrane | |
| clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane | |
| SNARE complex | |
| integral to plasma membrane | |
| integral to membrane | |
| synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex | |
| synaptobrevin 2-SNAP-25-syntaxin-1a complex | |
| plasma membrane | |
| intracellular organelle | |
| perinuclear region of cytoplasm | |
| cytoplasmic vesicle | |
| secretory granule | |
| clathrin-coated vesicle | |
| synaptic vesicle | |
| intracellular membrane-bounded organelle | |
| trans-Golgi network | |
| neuron projection |
| GO Biological Process | cellular membrane organization |
|---|---|
| synaptic transmission | |
| regulation of insulin secretion | |
| regulation of vesicle-mediated transport | |
| regulation of exocytosis | |
| positive regulation of intracellular protein transport | |
| glutamate secretion | |
| neurotransmitter secretion | |
| calcium ion-dependent exocytosis | |
| synaptic vesicle exocytosis | |
| energy reserve metabolic process | |
| cellular membrane fusion | |
| cellular response to insulin stimulus | |
| response to glucose stimulus | |
| vesicle-mediated transport | |
| Golgi to plasma membrane protein transport | |
| post-Golgi vesicle-mediated transport | |
| protein transport | |
| small molecule metabolic process | |
| protein complex assembly |
| Pathway | altered insulin secretion pathway |
|---|---|
| vasopressin signaling pathway - first | |
| insulin secretion pathway | |
| altered insulin secretion pathway | |
| insulin secretion pathway | |
| altered insulin secretion pathway | |
| insulin secretion pathway | |
| altered insulin secretion pathway |
| Group | Endosomal recycling |
|---|---|
| Vesicular secretory pathway | |
| cellular membrane organization | |
| synaptic transmission | |
| regulation of insulin secretion | |
| regulation of vesicle-mediated transport | |
| regulation of exocytosis | |
| positive regulation of intracellular protein transport | |
| glutamate secretion | |
| neurotransmitter secretion | |
| calcium ion-dependent exocytosis | |
| synaptic vesicle exocytosis | |
| energy reserve metabolic process | |
| cellular membrane fusion | |
| cellular response to insulin stimulus | |
| response to glucose stimulus | |
| vesicle-mediated transport | |
| Golgi to plasma membrane protein transport | |
| post-Golgi vesicle-mediated transport | |
| protein transport | |
| small molecule metabolic process | |
| protein complex assembly | |
| protein complex binding | |
| calmodulin binding | |
| SNARE binding | |
| protein C-terminus binding | |
| syntaxin binding | |
| syntaxin-1 binding | |
| myosin binding | |
| phospholipid binding | |
| cell junction | |
| membrane | |
| synapse | |
| secretory granule membrane | |
| endocytic vesicle membrane | |
| zymogen granule membrane | |
| clathrin-sculpted glutamate transport vesicle membrane | |
| clathrin-sculpted monoamine transport vesicle membrane | |
| synaptic vesicle membrane | |
| clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane | |
| SNARE complex | |
| integral to plasma membrane | |
| integral to membrane | |
| synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex | |
| synaptobrevin 2-SNAP-25-syntaxin-1a complex | |
| plasma membrane | |
| intracellular organelle | |
| perinuclear region of cytoplasm | |
| cytoplasmic vesicle | |
| secretory granule | |
| clathrin-coated vesicle | |
| synaptic vesicle | |
| intracellular membrane-bounded organelle | |
| trans-Golgi network | |
| neuron projection | |
| Secreted proteins |
| MedScan ID | 6844 |
|---|
| Hugo ID | 12643 |
|---|
| Human chromosome position | 17p13.1 |
|---|
| LocusLink ID | 6844 |
|---|---|
| 22318 | |
| 24803 |
| Alias | SYB2 |
|---|---|
| VAMP-2 | |
| vesicle-associated membrane protein 2 | |
| synaptobrevin 2 | |
| synaptobrevin-2 | |
| vesicle associated membrane protein 2 | |
| Syb-2 | |
| sybII | |
| RP23-26L6.8 | |
| synaptobrevin II | |
| vesicle-associated membrane 2 | |
| SYB | |
| RATVAMPB | |
| RATVAMPIR | |
| Vesicle-associated membrane protein (synaptobrevin 2) | |
| Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2) | |
| Vesicle-associated membrane protein II | |
| vesicle-associated membrane protein 2 (synaptobrevin 2) | |
| Vamp2 | |
| FLJ11460 | |
| OTTMUSP00000035737 | |
| OTTMUSP00000006177 | |
| vesicle-associated membrane protein VAMP-2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 185881 |
|---|
| Unigene ID | Hs.25348 |
|---|---|
| Mm.28643 | |
| Rn.12939 |
| KEGG ID | hsa:6844 |
|---|---|
| mmu:22318 | |
| rno:24803 |
| Swiss-Prot Accession | P63027 |
|---|---|
| P63044 | |
| Q8CHR4 | |
| P63045 | |
| Q64357 | |
| P19065 | |
| Q9BUC2 | |
| Q69Z01 | |
| O35619 | |
| Q19LA7 | |
| Q9WUW2 |
| GO ID | 0016044 |
|---|---|
| 0006112 | |
| 0014047 | |
| 0007269 | |
| 0006892 | |
| 0050796 | |
| 0044281 | |
| 0007268 | |
| 0031201 | |
| 0030054 | |
| 0030136 | |
| 0061202 | |
| 0060203 | |
| 0070083 | |
| 0030666 | |
| 0005887 | |
| 0043005 | |
| 0005886 | |
| 0030667 | |
| 0030672 | |
| 0000149 | |
| 0005516 | |
| 0017022 | |
| 0005543 | |
| 0008022 | |
| 0032403 | |
| 0019905 | |
| 0017075 | |
| 0043001 | |
| 0017156 | |
| 0006944 | |
| 0032869 | |
| 0090316 | |
| 0006461 | |
| 0015031 | |
| 0017157 | |
| 0060627 | |
| 0009749 | |
| 0016079 | |
| 0016192 | |
| 0031410 | |
| 0016021 | |
| 0043231 | |
| 0043229 | |
| 0016020 | |
| 0048471 | |
| 0030141 | |
| 0045202 | |
| 0008021 | |
| 0070044 | |
| 0070032 | |
| 0005802 | |
| 0042589 | |
| 0019717 | |
| 0005792 | |
| 0005515 |
| PIR ID | B34288 |
|---|---|
| B38315 |
| Swiss-Prot ID | VAMP2_RAT |
|---|---|
| VAMP2_MOUSE | |
| VAMP2_HUMAN | |
| Q8CHR4_MOUSE | |
| Q9BUC2_HUMAN |
| Cell Localization | Cytoplasmic vesicle |
|---|---|
| secretory vesicle | |
| synaptic vesicle membrane | |
| Cell junction | |
| synapse | |
| synaptosome | |
| Golgi | |
| Lysosome |
| IPI ID | IPI00781701 |
|---|---|
| IPI00229703 | |
| IPI00553138 | |
| IPI00465395 | |
| IPI00790248 | |
| IPI00791199 | |
| IPI00880852 | |
| IPI00204447 |
| Mouse chromosome position | 11 |
|---|---|
| 11 B3 |
| Rat chromosome position | 10q24 |
|---|
| Homologene ID | 7591 |
|---|
| MGI ID | 1313277 |
|---|
| RGD ID | 3949 |
|---|
| Primary Cell Localization | Golgi |
|---|---|
| Lysosome |