| URN | urn:agi-llid:6514 |
|---|---|
| Total Entities | 0 |
| Connectivity | 375 |
| Name | Slc2a2 |
| Description | solute carrier family 2 (facilitated glucose transporter), member 2 |
| Notes | Glucose transporter 2 isoform is an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. It mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. |
| Ariadne Ontology | Glucose import |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | transporter activity |
|---|---|
| insulin receptor binding | |
| transmembrane transporter activity | |
| substrate-specific transmembrane transporter activity | |
| hexose transmembrane transporter activity | |
| glucose transmembrane transporter activity | |
| D-glucose transmembrane transporter activity | |
| dehydroascorbic acid transporter activity |
| GO Cellular Component | membrane |
|---|---|
| basolateral plasma membrane | |
| integral to plasma membrane | |
| brush border membrane | |
| integral to membrane | |
| plasma membrane | |
| cytoplasm | |
| endosome | |
| cytosol | |
| brush border |
| GO Biological Process | transmembrane transport |
|---|---|
| regulation of insulin secretion | |
| energy reserve metabolic process | |
| hexose transmembrane transport | |
| response to peptide hormone stimulus | |
| response to glucose stimulus | |
| endocrine pancreas development | |
| carbohydrate utilization | |
| transport | |
| dehydroascorbic acid transport | |
| carbohydrate transport | |
| hexose transport | |
| glucose transport | |
| fructose transport | |
| carbohydrate metabolic process | |
| small molecule metabolic process |
| Pathway | TNF/STAT Expression Targets |
|---|---|
| Fibronectin Expression Targets | |
| EGF/CTNN Expression Targets | |
| altered insulin secretion pathway | |
| insulin secretion pathway | |
| altered insulin secretion pathway | |
| insulin secretion pathway | |
| altered insulin secretion pathway | |
| insulin secretion pathway | |
| altered insulin secretion pathway |
| Group | Glucose import |
|---|---|
| transmembrane transport | |
| regulation of insulin secretion | |
| energy reserve metabolic process | |
| hexose transmembrane transport | |
| response to peptide hormone stimulus | |
| response to glucose stimulus | |
| endocrine pancreas development | |
| carbohydrate utilization | |
| transport | |
| dehydroascorbic acid transport | |
| carbohydrate transport | |
| hexose transport | |
| glucose transport | |
| fructose transport | |
| carbohydrate metabolic process | |
| small molecule metabolic process | |
| transporter activity | |
| insulin receptor binding | |
| transmembrane transporter activity | |
| substrate-specific transmembrane transporter activity | |
| hexose transmembrane transporter activity | |
| glucose transmembrane transporter activity | |
| D-glucose transmembrane transporter activity | |
| dehydroascorbic acid transporter activity | |
| membrane | |
| basolateral plasma membrane | |
| integral to plasma membrane | |
| brush border membrane | |
| integral to membrane | |
| plasma membrane | |
| cytoplasm | |
| endosome | |
| cytosol | |
| brush border | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 6514 |
|---|
| Hugo ID | 11006 |
|---|
| Human chromosome position | 3q26.1-q26.2 |
|---|
| LocusLink ID | 6514 |
|---|---|
| 20526 | |
| 25351 |
| Alias | GLUT2 |
|---|---|
| solute carrier family 2, facilitated glucose transporter member 2 | |
| GLUT-2 | |
| glucose transporter type 2, liver | |
| AI266973 | |
| liver-type glucose transporter | |
| GTT2 | |
| Slc2a2 | |
| solute carrier family 2, member II | |
| solute carrier family 2, member 2 | |
| Solute carrier family 2 A2 (gkucose transporter, type 2) | |
| solute carrier family 2 a2 | |
| facilitated glucose transporter II | |
| facilitated glucose transporter 2 | |
| solute carrier family 2 (facilitated glucose transporter), member 2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 138160 |
|---|---|
| 227810 |
| Unigene ID | Hs.167584 |
|---|---|
| Mm.18443 | |
| Rn.89295 |
| KEGG ID | hsa:6514 |
|---|---|
| mmu:20526 | |
| rno:25351 |
| Swiss-Prot Accession | P11168 |
|---|---|
| P14246 | |
| Q68FZ1 | |
| P12336 | |
| Q3TNA5 | |
| Q9DBA7 | |
| A8K481 | |
| B2R936 | |
| Q9UCW9 | |
| Q6PAU8 | |
| Q63235 | |
| Q6LE97 | |
| Q6LE99 | |
| Q6LEA0 | |
| Q6LEA1 | |
| Q6LEA2 | |
| Q6LEA3 | |
| Q6LEA4 |
| GO ID | 0055056 |
|---|---|
| 0033300 | |
| 0005355 | |
| 0015149 | |
| 0005158 | |
| 0005975 | |
| 0031018 | |
| 0006112 | |
| 0015755 | |
| 0015758 | |
| 0035428 | |
| 0008645 | |
| 0050796 | |
| 0009749 | |
| 0043434 | |
| 0044281 | |
| 0055085 | |
| 0016323 | |
| 0031526 | |
| 0005829 | |
| 0005768 | |
| 0005887 | |
| 0016020 | |
| 0005886 | |
| 0022891 | |
| 0022857 | |
| 0005215 | |
| 0008643 | |
| 0009758 | |
| 0070837 | |
| 0006810 | |
| 0005903 | |
| 0005737 | |
| 0016021 | |
| 0005624 | |
| 0007587 | |
| 0005351 |
| PIR ID | S06920 |
|---|---|
| A31318 |
| Swiss-Prot ID | GTR2_MOUSE |
|---|---|
| GTR2_HUMAN | |
| Q68FZ1_RAT |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00311809 |
|---|---|
| IPI00003905 | |
| IPI00196643 | |
| IPI00744509 | |
| IPI00882453 | |
| IPI00882410 |
| Mouse chromosome position | 3 14.4 cM |
|---|
| Rat chromosome position | 2q24 |
|---|
| Homologene ID | 68047 |
|---|
| MGI ID | 1095438 |
|---|
| RGD ID | 3705 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|