| URN | urn:agi-llid:5873 |
|---|---|
| Total Entities | 0 |
| Connectivity | 213 |
| Name | Rab27a |
| Description | RAB27A, member RAS oncogene family |
| Notes | The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. |
| Ariadne Ontology | Vesicular secretory pathway |
|---|---|
| Oncogenes | |
| Secreted proteins |
| GO Molecular Function | protein domain specific binding |
|---|---|
| myosin V binding | |
| nucleotide binding | |
| GTP binding | |
| GTPase activity |
| GO Cellular Component | membrane |
|---|---|
| multivesicular body membrane | |
| secretory granule membrane | |
| apical plasma membrane | |
| intracellular | |
| endosome | |
| cytosol | |
| Golgi apparatus | |
| lysosome | |
| late endosome | |
| secretory granule | |
| exocytic vesicle | |
| melanosome | |
| photoreceptor outer segment | |
| dendrite |
| GO Biological Process | small GTPase mediated signal transduction |
|---|---|
| positive regulation of exocytosis | |
| melanocyte differentiation | |
| cytotoxic T cell degranulation | |
| natural killer cell degranulation | |
| exocytosis | |
| pigment granule localization | |
| melanosome localization | |
| pigmentation | |
| blood coagulation | |
| pigment granule transport | |
| vesicle-mediated transport | |
| protein targeting | |
| protein transport | |
| multivesicular body sorting pathway | |
| melanosome transport |
| Pathway | altered insulin secretion pathway |
|---|---|
| insulin secretion pathway | |
| altered insulin secretion pathway | |
| insulin secretion pathway | |
| altered insulin secretion pathway | |
| insulin secretion pathway | |
| altered insulin secretion pathway |
| Group | Vesicular secretory pathway |
|---|---|
| Oncogenes | |
| small GTPase mediated signal transduction | |
| positive regulation of exocytosis | |
| melanocyte differentiation | |
| cytotoxic T cell degranulation | |
| natural killer cell degranulation | |
| exocytosis | |
| pigment granule localization | |
| melanosome localization | |
| pigmentation | |
| blood coagulation | |
| pigment granule transport | |
| vesicle-mediated transport | |
| protein targeting | |
| protein transport | |
| multivesicular body sorting pathway | |
| melanosome transport | |
| protein domain specific binding | |
| myosin V binding | |
| nucleotide binding | |
| GTP binding | |
| GTPase activity | |
| membrane | |
| multivesicular body membrane | |
| secretory granule membrane | |
| apical plasma membrane | |
| intracellular | |
| endosome | |
| cytosol | |
| Golgi apparatus | |
| lysosome | |
| late endosome | |
| secretory granule | |
| exocytic vesicle | |
| melanosome | |
| photoreceptor outer segment | |
| dendrite | |
| Secreted proteins |
| MedScan ID | 5873 |
|---|
| Hugo ID | 9766 |
|---|
| Human chromosome position | 15q15-q21.1 |
|---|
| LocusLink ID | 5873 |
|---|---|
| 11891 | |
| 50645 |
| Alias | GS2 |
|---|---|
| RAM | |
| RAB27 | |
| HsT18676 | |
| ras-related protein Rab-27A | |
| rab-27 | |
| GTP-binding protein Ram | |
| ash | |
| 2210402C08Rik | |
| 2410003M20Rik | |
| 4933437C11Rik | |
| ashen | |
| ram p25 | |
| low Mr GTP-binding protein | |
| MGC112618 | |
| protein RAM | |
| Rab27a | |
| RAB27A, member RAS oncogene family | |
| RAM (associated with p25) | |
| RAM protein | |
| MGC117246 | |
| 2410003M20 | |
| 4933437C11 | |
| ash protein | |
| 2210402C08 | |
| RAB27A protein | |
| RIKEN cDNA 2210402C08 gene | |
| RIKEN cDNA 2410003M20 gene | |
| RIKEN cDNA 4933437C11 gene |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603868 |
|---|---|
| 607624 |
| Unigene ID | Hs.654978 |
|---|---|
| Mm.34867 | |
| Rn.37360 |
| KEGG ID | hsa:5873 |
|---|---|
| mmu:11891 | |
| rno:50645 |
| Swiss-Prot Accession | A2RU94 |
|---|---|
| P51159 | |
| Q544U7 | |
| Q9ERI2 | |
| P23640 | |
| O00195 | |
| Q6FI40 | |
| Q9UIR9 | |
| Q9Y5U3 | |
| Q4KMA7 | |
| Q6IAS8 |
| GO ID | 0005525 |
|---|---|
| 0003924 | |
| 0031489 | |
| 0007596 | |
| 0043316 | |
| 0006887 | |
| 0030318 | |
| 0032402 | |
| 0071985 | |
| 0043320 | |
| 0045921 | |
| 0006605 | |
| 0007264 | |
| 0005794 | |
| 0016324 | |
| 0030425 | |
| 0070382 | |
| 0005770 | |
| 0005764 | |
| 0042470 | |
| 0032585 | |
| 0001750 | |
| 0030667 | |
| 0000166 | |
| 0019904 | |
| 0032400 | |
| 0051875 | |
| 0051904 | |
| 0043473 | |
| 0015031 | |
| 0016192 | |
| 0005768 | |
| 0005622 | |
| 0016020 | |
| 0030141 | |
| 0005829 | |
| 0005737 | |
| 0005515 |
| PIR ID | I39198 |
|---|---|
| S12959 |
| Swiss-Prot ID | RB27A_HUMAN |
|---|---|
| RB27A_RAT | |
| RB27A_MOUSE | |
| A2RU94_HUMAN | |
| Q544U7_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Melanosome | |
| Late endosome | |
| Lysosome | |
| Golgi |
| IPI ID | IPI00016381 |
|---|---|
| IPI00219858 | |
| IPI00212794 | |
| IPI00112374 |
| Mouse chromosome position | 9 41.0 cM |
|---|
| Rat chromosome position | 8q24 |
|---|
| Homologene ID | 3069 |
|---|
| MGI ID | 1861441 |
|---|
| RGD ID | 620918 |
|---|
| Primary Cell Localization | Golgi |
|---|