| URN | urn:agi-llid:2645 |
|---|---|
| Connectivity | 259 |
| Name | Gck |
| Description | glucokinase (hexokinase 4) |
| Notes | Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). |
| Pathway | insulin secretion pathway |
|---|---|
| altered insulin secretion pathway | |
| altered insulin secretion pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| protein phosphatase binding | |
| ADP binding | |
| ATP binding | |
| glucose binding | |
| magnesium ion binding | |
| phosphotransferase activity, alcohol group as acceptor | |
| kinase activity | |
| hexokinase activity | |
| glucokinase activity |
| GO Cellular Component | soluble fraction |
|---|---|
| cytoplasm | |
| cell cortex part | |
| cell cortex | |
| cytosol | |
| mitochondrion | |
| stored secretory granule | |
| nucleoplasm | |
| actin filament | |
| nucleus |
| GO Biological Process | regulation of insulin secretion |
|---|---|
| positive regulation of insulin secretion | |
| cellular response to glucose starvation | |
| second-messenger-mediated signaling | |
| positive regulation of glycolysis | |
| negative regulation of gluconeogenesis | |
| positive regulation of glycogen biosynthetic process | |
| positive regulation of phosphorylation | |
| negative regulation of epinephrine secretion | |
| glycolysis | |
| carbohydrate phosphorylation | |
| glycogen biosynthetic process | |
| glucose metabolic process | |
| fructose 2,6-bisphosphate metabolic process | |
| glucose 6-phosphate metabolic process | |
| NADP metabolic process | |
| cellular glucose homeostasis | |
| elevation of cytosolic calcium ion concentration | |
| detection of glucose | |
| response to glucose stimulus | |
| regulation of potassium ion transport | |
| carbohydrate metabolic process | |
| glucose homeostasis |
| Ariadne Ontology | Glucose metabolism |
|---|---|
| Glycogen degradation |
| Group | Glucose metabolism |
|---|---|
| Glycogen degradation | |
| regulation of insulin secretion | |
| positive regulation of insulin secretion | |
| cellular response to glucose starvation | |
| second-messenger-mediated signaling | |
| positive regulation of glycolysis | |
| negative regulation of gluconeogenesis | |
| positive regulation of glycogen biosynthetic process | |
| positive regulation of phosphorylation | |
| negative regulation of epinephrine secretion | |
| glycolysis | |
| carbohydrate phosphorylation | |
| glycogen biosynthetic process | |
| glucose metabolic process | |
| fructose 2,6-bisphosphate metabolic process | |
| glucose 6-phosphate metabolic process | |
| NADP metabolic process | |
| cellular glucose homeostasis | |
| elevation of cytosolic calcium ion concentration | |
| detection of glucose | |
| response to glucose stimulus | |
| regulation of potassium ion transport | |
| carbohydrate metabolic process | |
| glucose homeostasis | |
| nucleotide binding | |
| transferase activity | |
| protein phosphatase binding | |
| ADP binding | |
| ATP binding | |
| glucose binding | |
| magnesium ion binding | |
| phosphotransferase activity, alcohol group as acceptor | |
| kinase activity | |
| hexokinase activity | |
| glucokinase activity | |
| soluble fraction | |
| cytoplasm | |
| cell cortex part | |
| cell cortex | |
| cytosol | |
| mitochondrion | |
| stored secretory granule | |
| nucleoplasm | |
| actin filament | |
| nucleus |
| MedScan ID | 2645 |
|---|
| Hugo ID | 4195 |
|---|
| Human chromosome position | 7p15.3-p15.1 |
|---|
| LocusLink ID | 2645 |
|---|---|
| 103988 | |
| 24385 |
| Alias | GK |
|---|---|
| GLK | |
| HK4 | |
| HHF3 | |
| HKIV | |
| HXKP | |
| LGLK | |
| MODY2 | |
| FGQTL3 | |
| glucokinase | |
| HK IV | |
| hexokinase-4 | |
| hexokinase-D | |
| OTTHUMP00000209239 | |
| hexokinase type IV | |
| hexokinase D, pancreatic isozyme | |
| ATP:D-hexose 6-phosphotransferase | |
| RP23-340E18.1 | |
| hexokinase 4 | |
| OTTMUSP00000006665 | |
| OTTMUSP00000006667 | |
| GLUKA | |
| RNGK2 | |
| ATP:D-hexose 6-phosphotransferase 4 | |
| ATP:D-hexose 6-phosphotransferase IV | |
| GCK | |
| GCK/MODY2 | |
| glucokinase (hexokinase 4) | |
| glucokinase isoform 1 | |
| glucokinase isoform 2 | |
| glucokinase isoform 3 | |
| glucokinase isoform I | |
| glucokinase isoform II | |
| glucokinase isoform III | |
| hexokinase 4, maturity onset diabetes of the young 2 | |
| hexokinase 4, maturity onset diabetes of the young II | |
| maturity onset diabetes of the young protein 2 | |
| maturity onset diabetes of the young protein II | |
| OTTHUMP00000024521 | |
| OTTHUMP00000159308 | |
| HK IV | |
| pancreatic isozyme |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 138079 |
|---|---|
| 125851 | |
| 125853 | |
| 606176 | |
| 602485 | |
| 606391 |
| Mouse chromosome position | 11 1.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0004340 | |
| 0005536 | |
| 0016301 | |
| 0000166 | |
| 0016740 | |
| 0005975 | |
| 0051594 | |
| 0042593 | |
| 0006006 | |
| 0006096 | |
| 0045721 | |
| 0045725 | |
| 0032024 | |
| 0005829 | |
| 0005654 | |
| 0043531 | |
| 0004396 | |
| 0000287 | |
| 0016773 | |
| 0019903 | |
| 0006739 | |
| 0046835 | |
| 0001678 | |
| 0042149 | |
| 0007204 | |
| 0006003 | |
| 0051156 | |
| 0005978 | |
| 0032811 | |
| 0045821 | |
| 0042327 | |
| 0050796 | |
| 0043266 | |
| 0019932 | |
| 0005884 | |
| 0005938 | |
| 0044448 | |
| 0005737 | |
| 0005739 | |
| 0005634 | |
| 0005625 | |
| 0030141 | |
| 0009749 | |
| 0005515 |
| Rat chromosome position | 14q21 |
|---|
| Swiss-Prot Accession | P35557 |
|---|---|
| Q53Y25 | |
| P52792 | |
| Q5SVI5 | |
| Q5SVI6 | |
| Q5SVI7 | |
| Q6LE83 | |
| P17712 | |
| Q64596 | |
| Q78E09 | |
| P52791 | |
| A4D2J2 | |
| A4D2J3 | |
| Q05810 | |
| P17711 |
| PIR ID | I49693 |
|---|---|
| I49694 | |
| A46157 | |
| B46157 | |
| C46157 | |
| A31810 | |
| I84740 |
| Unigene ID | Hs.1270 |
|---|---|
| Mm.220358 | |
| Rn.10447 |
| KEGG ID | hsa:2645 |
|---|---|
| mmu:103988 | |
| rno:24385 |
| EC Number | 2.7.1.2 |
|---|
| Swiss-Prot ID | HXK4_MOUSE |
|---|---|
| HXK4_HUMAN | |
| HXK4_RAT | |
| Q5SVI5_MOUSE | |
| Q53Y25_HUMAN | |
| A4D2J2_HUMAN | |
| A4D2J3_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00130751 |
|---|---|
| IPI00229807 | |
| IPI00218767 | |
| IPI00218768 | |
| IPI00244083 | |
| IPI00190888 | |
| IPI00202358 | |
| IPI00231947 | |
| IPI00903108 | |
| IPI00915098 | |
| IPI00648187 | |
| IPI00213666 |
| Homologene ID | 55440 |
|---|
| RGD ID | 2670 |
|---|
| MGI ID | 1270854 |
|---|