Protein Snap25

URN	urn:agi-llid:6616
Connectivity	214
Name	Snap25
Description	synaptosomal-associated protein, 25kDa
Notes	Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene.

Pathway	insulin secretion pathway
	altered insulin secretion pathway
	altered insulin secretion pathway

GO Molecular Function	protein N-terminus binding
	SNARE binding
	SNAP receptor activity
	myosin binding
	syntaxin-1 binding
	voltage-gated potassium channel activity

GO Cellular Component	synapse
	membrane
	plasma membrane
	neuron projection
	growth cone
	cytoplasm
	membrane raft
	SNARE complex
	endosome
	perinuclear region of cytoplasm
	trans-Golgi network
	synaptosome
	voltage-gated potassium channel complex
	cell junction
	synaptobrevin 2-SNAP-25-syntaxin-1a complex
	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex

GO Biological Process	sleep
	regulation of synaptogenesis
	axonogenesis
	long-term memory
	endosome transport
	exocytosis
	neurotransmitter secretion
	positive regulation of hormone secretion
	synaptic transmission
	regulation of insulin secretion
	positive regulation of insulin secretion
	calcium ion-dependent exocytosis of neurotransmitter
	growth hormone secretion
	synaptic vesicle docking involved in exocytosis
	neurotransmitter uptake

Ariadne Ontology	Vesicular secretory pathway
	Endosomal recycling

Group	Vesicular secretory pathway
	Endosomal recycling
	synapse
	sleep
	regulation of synaptogenesis
	axonogenesis
	long-term memory
	endosome transport
	exocytosis
	neurotransmitter secretion
	positive regulation of hormone secretion
	synaptic transmission
	regulation of insulin secretion
	positive regulation of insulin secretion
	calcium ion-dependent exocytosis of neurotransmitter
	growth hormone secretion
	synaptic vesicle docking involved in exocytosis
	neurotransmitter uptake
	protein N-terminus binding
	SNARE binding
	SNAP receptor activity
	myosin binding
	syntaxin-1 binding
	voltage-gated potassium channel activity
	membrane
	plasma membrane
	neuron projection
	growth cone
	cytoplasm
	membrane raft
	SNARE complex
	endosome
	perinuclear region of cytoplasm
	trans-Golgi network
	synaptosome
	voltage-gated potassium channel complex
	cell junction
	synaptobrevin 2-SNAP-25-syntaxin-1a complex
	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex

MedScan ID	6616

Hugo ID	11132

Human chromosome position	20p12-p11.2

Alias	RIC4
	SEC9
	SNAP
	RIC-4
	SNAP-25
	FLJ23079
	bA416N4.2
	dJ1068F16.2
	synaptosomal-associated protein 25
	SUP
	super protein
	synaptosomal-associated 25 kDa protein
	resistance to inhibitors of cholinesterase 4 homolog
	sp
	Bdr
	RP23-142F14.2
	GENA 70
	blind drunk
	OTTMUSP00000016582
	synaptosomal-associated protein, 25 kDa
	SNAP-25B
	MGC105414
	25 kDa synaptosomal-associated protein
	bA416N4
	blind drunk gene
	dJ1068F16
	OTTHUMP00000030267
	OTTHUMP00000030268
	PIR:G02238
	SN25
	SN25_HUMAN
	SNAP25
	snap25a
	Synaptosomal-accosiated protein 25 kDa
	synaptosomal-associated 25K protein
	synaptosomal-associated protein 25 isoform SNAP25A
	synaptosomal-associated protein 25 isoform SNAP25B
	synaptosomal-associated protein, 25kD
	synaptosomal-associated protein, 25kDa
	SNAP25s
	GENA 70s
	synaptosomal-associated protein
	isoform snap25a

OMIM ID	600322

Mouse chromosome position	2 78.2 cM

Rat chromosome position	3q36

Homologene ID	13311

RGD ID	3728

MGI ID	98331