| URN | urn:agi-llid:998 |
|---|---|
| Connectivity | 942 |
| Name | Cdc42 |
| Description | cell division cycle 42 homolog (S. cerevisiae) |
| Notes | small GTPase; involved in formation of cellular asymmetry [RGD] |
| Pathway | FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling |
|---|---|
| PDGFR -> AP-1/MYC signaling | |
| VEGFR -> AP-1/CREB/MYC signaling | |
| HGFR -> AP-1/CREB/MYC signaling | |
| AngiopoietinR -> AP-1 signaling | |
| ErythropoietinR -> AP-1/CREB/MYC signaling | |
| ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> NCOR2 signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| GDNF -> HSF1 signaling | |
| IGF1R -> MEF/MYOD/MYOG signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| KIT -> MITF signaling | |
| VEGFR -> NFATC signaling | |
| VEGFR -> ATF/CREB/ELK-SRF signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| DopamineR2 -> AP-1/CREB/ELK-SRF signaling | |
| VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling | |
| EndothelinRb -> AP-1/CREB/ELK-SRF signaling | |
| EndothelinRa -> AP-1/CREB signaling | |
| VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling | |
| T-cell receptor -> ATF/CREB signaling | |
| AGER -> CREB/SP1 signaling | |
| TLR1/2/6 -> NF-kB signaling | |
| c-Jun N-terminal kinases MAPK signaling pathway | |
| insulin secretion pathway | |
| altered insulin secretion pathway | |
| altered insulin secretion pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| thioesterase binding | |
| GTP binding | |
| GTPase activity |
| GO Cellular Component | intracellular |
|---|---|
| plasma membrane | |
| filopodium | |
| cytoplasm | |
| cytosol |
| GO Biological Process | establishment or maintenance of cell polarity |
|---|---|
| macrophage differentiation | |
| actin cytoskeleton organization | |
| small GTPase mediated signal transduction | |
| positive regulation of pseudopodium assembly | |
| negative regulation of protein complex assembly |
| Ariadne Ontology | Rac-CDC42 |
|---|
| Group | Rac-CDC42 |
|---|---|
| establishment or maintenance of cell polarity | |
| macrophage differentiation | |
| actin cytoskeleton organization | |
| small GTPase mediated signal transduction | |
| positive regulation of pseudopodium assembly | |
| negative regulation of protein complex assembly | |
| nucleotide binding | |
| thioesterase binding | |
| GTP binding | |
| GTPase activity | |
| intracellular | |
| plasma membrane | |
| filopodium | |
| cytoplasm | |
| cytosol |
| MedScan ID | 998 |
|---|
| Hugo ID | 1736 |
|---|
| Human chromosome position | 1p36.1 |
|---|
| LocusLink ID | 998 |
|---|---|
| 12540 | |
| 64465 | |
| 100285 | |
| 100196 | |
| 281676 | |
| 532712 | |
| 336839 | |
| 393605 | |
| 553175 |
| Alias | G25K |
|---|---|
| CDC42Hs | |
| RP1-224A6.5 | |
| cell division control protein 42 homolog | |
| OTTHUMP00000002834 | |
| OTTHUMP00000002927 | |
| G25K GTP-binding protein | |
| GTP-binding protein, 25kD | |
| growth-regulating protein | |
| small GTP binding protein CDC42 | |
| dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)) | |
| dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)) | |
| 25 kDa GTP-binding protein | |
| CDC42 | |
| Cdc42 Rho GTPase | |
| cell division cycle 42 | |
| cell division cycle 42 (GTP binding protein) | |
| cell division cycle 42 (GTP binding protein, 25kD) | |
| cell division cycle 42 (GTP binding protein, 25kDa) | |
| cell division cycle 42 homolog | |
| cell division cycle 42 homolog (S. cerevisiae) | |
| cell division cycle 42 isoform 1 | |
| cell division cycle 42 isoform 2 | |
| cell division cycle 42 isoform I | |
| cell division cycle 42 isoform II | |
| G25K GTP-binding protein, placental isoform | |
| G25P | |
| G25P_HUMAN | |
| GTP-binding G25K, placental | |
| OTTHUMP00000002926 | |
| Rho GTPase Cdc42 | |
| cell division cycle 42 (GTP-binding protein, 25kD) | |
| AI747189 | |
| AU018915 | |
| RP23-246F18.2 | |
| small GTP binding protein | |
| Cdc42 protein homolog | |
| MGC63918 | |
| cdc42a | |
| chromosome | |
| fb07d08 | |
| scaffold | |
| wu:fb07d08 | |
| zgc:63918 | |
| hypothetical protein MGC63918 | |
| ras-like protein Cdc42a |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 116952 |
|---|
| Mouse chromosome position | 4 66.75 cM |
|---|
| GO ID | 0005525 |
|---|---|
| 0003924 | |
| 0000166 | |
| 0031996 | |
| 0030036 | |
| 0007163 | |
| 0030225 | |
| 0031333 | |
| 0031274 | |
| 0007264 | |
| 0005737 | |
| 0005829 | |
| 0030175 | |
| 0005622 | |
| 0005886 | |
| 0005515 | |
| 0030742 | |
| 0051301 | |
| 0046847 | |
| 0007097 | |
| 0043552 | |
| 0007266 | |
| 0007015 | |
| 0016337 | |
| 0016197 | |
| 0042995 | |
| 0016020 | |
| 0030010 | |
| 0001558 | |
| 0051318 | |
| 0015031 | |
| 0007049 | |
| 0000910 | |
| 0000074 | |
| 0005579 |
| Rat chromosome position | 5q36 |
|---|
| Swiss-Prot Accession | P60953 |
|---|---|
| Q5JYX0 | |
| Q9UJM0 | |
| Q9UJM1 | |
| P21181 | |
| P25763 | |
| Q7L8R5 | |
| Q9UDI2 | |
| P50290 | |
| Q545V0 | |
| P60766 |
| PIR ID | A36382 |
|---|---|
| A39265 |
| Unigene ID | Hs.467637 |
|---|---|
| Hs.690198 | |
| Mm.1022 | |
| Mm.447553 | |
| Mm.471693 | |
| Rn.60067 | |
| Mm.323783 | |
| Mm.426418 | |
| Mm.381404 | |
| Hs.597524 | |
| Bt.56113 | |
| Dr.104797 |
| KEGG ID | hsa:998 |
|---|---|
| mmu:12540 | |
| rno:64465 |
| Swiss-Prot ID | CDC42_HUMAN |
|---|
| Cell Localization | Cell membrane |
|---|---|
| Cytoplasm | |
| Plasma membrane |
| IPI ID | IPI00007189 |
|---|---|
| IPI00016786 | |
| IPI00642590 |
| Homologene ID | 1357 |
|---|
| RGD ID | 71043 |
|---|
| MGI ID | 106211 |
|---|---|
| 2140354 | |
| 2140443 |
| Microarray ID | 94105_at |
|---|---|
| 1435807_at |
| FunctionalClass | GTP binding |
|---|---|
| GTPase | |
| nucleotide binding | |
| protein binding | |
| GTP-dependent protein binding |
| Mus musculus Chromosome position | 4 66.75 cM |
|---|---|
| 4 |
| Source | Curated |
|---|---|
| ResNet | |
| GO component | |
| RGD modified |
| KEGG pathway | Adherens junction |
|---|---|
| Axon guidance | |
| Focal adhesion | |
| GnRH signaling pathway | |
| Leukocyte transendothelial migration | |
| MAPK signaling pathway | |
| Pancreatic cancer | |
| Regulation of actin cytoskeleton | |
| Renal cell carcinoma | |
| T cell receptor signaling pathway | |
| Tight junction | |
| VEGF signaling pathway |
| Homo sapiens Chromosome position | 1p36.1 |
|---|
| Bos taurus Chromosome position | 2 |
|---|
| Rattus norvegicus Chromosome position | 5q36 |
|---|