Elsevier Inc. Cdc42 Rab27a Slc2a2 Gck NADPH ATP ATP biosynthetic pathway electron transport chain pathway oxidative phosphorylation pathway citric acid cycle pathway pyruvate metabolic pathway Snap25 ---| voltage-gated K+ channels membrane repolarization ---| voltage-gated Ca2+ channels membrane depolarization --+> voltage-gated Ca2+ channels Ca2+ glucose-6-P D-glucose elevated glucose levels elevated glucose levels ---> D-glucose Snap25 ---- voltage-gated K+ channels Munc proteins ---> Stx1a pyruvate cycling D-glucose ---> glucose-6-P glucose-6-P ---> glycolysis pathway membrane repolarization voltage-gated Ca2+ channels ---> Ca2+ insulin released citric acid cycle pathway ---> pyruvate cycling membrane depolarization ATP-sensitive K+ channels ---> membrane depolarization voltage-gated K+ channels ---> membrane repolarization Rab family mediated signaling pathway Rho/Rac/Cdc42 mediated signaling pathway Snap25 Vamp2 Rab3a ATP-sensitive K+ channels voltage-gated Ca2+ channels voltage-gated K+ channels Syt proteins Munc proteins Stx1a membrane depolarization --+> voltage-gated K+ channels glycolysis pathway pyruvate metabolic pathway ---> pyruvate cycling ATP ---> ATP-sensitive K+ channels