Protein Exo1

URN	urn:agi-llid:8571
Connectivity	76
Name	Exo1
Description	exonuclease 1
Notes	This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms.

Pathway	mismatch repair pathway

GO Molecular Function	catalytic activity
	hydrolase activity
	DNA binding
	structure-specific DNA binding
	metal ion binding
	magnesium ion binding
	nuclease activity
	endonuclease activity
	exonuclease activity
	5'-3' exonuclease activity
	ribonuclease H activity
	flap endonuclease activity
	5'-3' exodeoxyribonuclease activity
	single-stranded DNA specific 5'-3' exodeoxyribonuclease activity
	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity

GO Cellular Component	nucleus

GO Biological Process	meiosis
	isotype switching
	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
	DNA recombination
	DNA repair
	mismatch repair
	response to DNA damage stimulus
	humoral immune response mediated by circulating immunoglobulin
	somatic hypermutation of immunoglobulin genes

Ariadne Ontology	DNA recombination
	DNA repair

Group	DNA recombination
	DNA repair
	catalytic activity
	meiosis
	isotype switching
	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
	DNA recombination
	DNA repair
	mismatch repair
	response to DNA damage stimulus
	humoral immune response mediated by circulating immunoglobulin
	somatic hypermutation of immunoglobulin genes
	hydrolase activity
	DNA binding
	structure-specific DNA binding
	metal ion binding
	magnesium ion binding
	nuclease activity
	endonuclease activity
	exonuclease activity
	5'-3' exonuclease activity
	ribonuclease H activity
	flap endonuclease activity
	5'-3' exodeoxyribonuclease activity
	single-stranded DNA specific 5'-3' exodeoxyribonuclease activity
	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity
	nucleus

MedScan ID	8571

Hugo ID	3511

Human chromosome position	1q42-q43

Alias	HEX1
	hExoI
	RP11-553N16.2
	exonuclease 1
	hExo1
	exonuclease I
	rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1
	Msa
	5730442G03Rik
	mExo1
	5'-3' exonuclease HEX I
	5'-3' exonuclease HEX1
	5730442G03
	EXO I
	EXO1
	EXO1A
	HEX I
	homolog of S. cerevisiae exonuclease 1
	OTTHUMP00000037878
	OTTHUMP00000037879
	Probable serine protease HTRA4
	rad2 nuclease family member, homolog of S. cerevisiae exonuclease I
	Probable serine protease HTRA4 precursor
	B430206E18
	RIKEN cDNA B430206E18 gene
	RIKEN cDNA 5730442G03 gene
	rad2 nuclease family member, homolog of S. cerevisiae
	hypothetical protein FLJ90724
	similar to exonuclease I
	Putative 5'-3' exonuclease HEX1
	Putative 5'-3' exonuclease HEX I
	hypothetical protein B430206E18
	rad2 nuclease family member

OMIM ID	606063

Mouse chromosome position	1 97.0 cM

Rat chromosome position	13q25

PIR ID	T12524

EC Number	3.1.-.-

Swiss-Prot ID	EXO1_HUMAN
	EXO1_MOUSE

Cell Localization	Nucleus

Homologene ID	31352

RGD ID	1309465

MGI ID	1349427