| URN | urn:agi-llid:5106 |
|---|---|
| Total Entities | 0 |
| Connectivity | 68 |
| Name | PCK2 |
| Description | phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
| Notes | This gene encodes a member of the phosphoenolpyruvate carboxykinase (GTP) family. The protein is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of GTP. A cytosolic form encoded by a different gene has also been characterized and is the key enzyme of gluconeogenesis in the liver. The encoded protein may serve a similar function, although it is constitutively expressed and not modulated by hormones such as glucagon and insulin that regulate the cytosolic form. Alternatively spliced transcript variants have been described. |
| GO Molecular Function | lyase activity |
|---|---|
| carboxy-lyase activity | |
| phosphoenolpyruvate carboxykinase activity | |
| phosphoenolpyruvate carboxykinase (GTP) activity | |
| nucleotide binding | |
| purine nucleotide binding | |
| GTP binding | |
| metal ion binding |
| GO Cellular Component | mitochondrial matrix |
|---|---|
| mitochondrion |
| GO Biological Process | small molecule metabolic process |
|---|---|
| gluconeogenesis | |
| glucose metabolic process | |
| NADH oxidation | |
| pyruvate metabolic process | |
| oxaloacetate metabolic process | |
| positive regulation of insulin secretion | |
| cellular response to glucose stimulus | |
| response to glucocorticoid | |
| carbohydrate metabolic process |
| Pathway | Insulin Resistance in Hepatocytes |
|---|---|
| Role of Adiponectin in Insulin Resistance Prevention | |
| Proteins Involved in Pathogenesis of Diabetes Mellitus Type 2 | |
| TGFB1-TGFBR2 Expression Targets | |
| GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| GH1-GHR/STAT Expression Targets | |
| PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| PRL-GHR/STAT Expression Targets | |
| PRL-PRLR Expression Targets | |
| Leptin/ELK-SRF Expression Targets | |
| Leptin/STAT Expression Targets | |
| CCL2 Expression Targets | |
| Epinephrine/Gq Expression Targets | |
| Epinephrine/Gs Expression Targets | |
| GCG Expression Targets | |
| POMC Expression Targets | |
| IGF1/CEBPA/FOXO1A Expression Targets | |
| Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| Insulin/STAT Expression Targets | |
| TNF/NF-kB Expression Targets | |
| AGT/CREB Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| gluconeogenesis pathway |
| Group | Tricarboxylic acid cycle |
|---|---|
| small molecule metabolic process | |
| gluconeogenesis | |
| glucose metabolic process | |
| NADH oxidation | |
| pyruvate metabolic process | |
| oxaloacetate metabolic process | |
| positive regulation of insulin secretion | |
| cellular response to glucose stimulus | |
| response to glucocorticoid | |
| lyase activity | |
| carboxy-lyase activity | |
| phosphoenolpyruvate carboxykinase activity | |
| phosphoenolpyruvate carboxykinase (GTP) activity | |
| carbohydrate metabolic process | |
| nucleotide binding | |
| purine nucleotide binding | |
| GTP binding | |
| metal ion binding | |
| mitochondrial matrix | |
| mitochondrion | |
| Secreted proteins |
| LocusLink ID | 5106 |
|---|---|
| 74551 | |
| 361042 |
| Cell Localization | Mitochondria |
|---|---|
| Mitochondrion |
| GO ID | 0005525 |
|---|---|
| 0046872 | |
| 0004613 | |
| 0004611 | |
| 0005975 | |
| 0006094 | |
| 0006006 | |
| 0044281 | |
| 0005759 | |
| 0005739 | |
| 0016831 | |
| 0016829 | |
| 0000166 | |
| 0017076 | |
| 0006116 | |
| 0006107 | |
| 0032024 | |
| 0006090 | |
| 0071333 | |
| 0051384 | |
| 0030145 | |
| 0016301 | |
| 0003674 | |
| 0005575 |
| Alias | PEPCK |
|---|---|
| PEPCK2 | |
| PEPCK-M | |
| phosphoenolpyruvate carboxykinase [GTP], mitochondrial | |
| PEP carboxykinase | |
| phosphopyruvate carboxylase | |
| phosphoenolpyruvate carboxylase | |
| 1810010O14Rik | |
| 9130022B02Rik | |
| phosphoenolpyruvate carboxykinase 2 (mitochondrial) | |
| PEPCK-Ms | |
| phosphoenolpyruvate carboxykinase (GTP), mitochondrial | |
| phosphoenolpyruvate carboxykinase 2 | |
| Phosphoenolpyruvate carboxykinase, mitochondrial precursor (GTP) | |
| Phosphoenolpyruvate carboxylase 2 | |
| RATPEPCK | |
| Phosphoenolpyruvate carboxylase II | |
| RIKEN cDNA 1810010O14 gene | |
| 1810010O14 | |
| 9130022B02 | |
| gAF1/PCK2 | |
| mitochondrial phosphoenolpyruvate carboxykinase 2 | |
| mitochondrial phosphoenolpyruvate carboxykinase II | |
| mitochondrial Phosphoenolpyruvate carboxykinase precursor (GTP) | |
| OTTHUMP00000164700 | |
| PCK2 | |
| RIKEN cDNA 9130022B02 gene | |
| PEPCK2s |
| Mouse chromosome position | 14 28.19 cM |
|---|---|
| 14 21.0 cM |
| OMIM ID | 614095 |
|---|---|
| 261650 |
| Rat chromosome position | 15p13 |
|---|
| Hugo ID | 8725 |
|---|
| Human chromosome position | 14q11.2 |
|---|---|
| 14q12 |
| Swiss-Prot Accession | Q16822 |
|---|---|
| B4DW73 | |
| Q8BH04 | |
| B2RYG2 | |
| Q8BMM9 | |
| Q91Z10 | |
| O43253 | |
| Q86U01 | |
| Q9BV62 |
| PIR ID | S69546 |
|---|
| Unigene ID | Hs.75812 |
|---|---|
| Mm.29856 | |
| Mm.491140 | |
| Rn.35508 |
| KEGG ID | hsa:5106 |
|---|---|
| mmu:74551 | |
| rno:361042 |
| Swiss-Prot ID | PCKGM_MOUSE |
|---|---|
| PCKGM_HUMAN |
| EC Number | 4.1.1.32 |
|---|
| Ensembl ID | ENSG00000100889 |
|---|---|
| ENSP00000380171 | |
| ENST00000396973 | |
| ENSP00000216780 | |
| ENST00000216780 | |
| ENSP00000454011 | |
| ENST00000561286 | |
| ENSP00000441826 | |
| ENST00000545054 | |
| ENSMUSG00000040618 | |
| ENSMUSP00000038555 | |
| ENSMUST00000048781 |
| Homologene ID | 3356 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1860456 |
|---|
| RGD ID | 1311112 |
|---|
| MedScan ID | 5106 |
|---|