| URN | urn:agi-llid:5105 |
|---|---|
| Total Entities | 0 |
| Connectivity | 299 |
| Name | PCK1 |
| Description | phosphoenolpyruvate carboxykinase 1 (soluble) |
| Notes | This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. A mitochondrial isozyme of the encoded protein also has been characterized. |
| GO Molecular Function | lyase activity |
|---|---|
| transferase activity | |
| kinase activity | |
| carboxy-lyase activity | |
| phosphoenolpyruvate carboxykinase activity | |
| phosphoenolpyruvate carboxykinase (GTP) activity | |
| nucleotide binding | |
| purine nucleotide binding | |
| GDP binding | |
| GTP binding | |
| carboxylic acid binding | |
| metal ion binding | |
| magnesium ion binding | |
| manganese ion binding |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol |
| GO Biological Process | lipid metabolic process |
|---|---|
| small molecule metabolic process | |
| glycerol biosynthetic process from pyruvate | |
| gluconeogenesis | |
| glucose metabolic process | |
| oxaloacetate metabolic process | |
| response to activity | |
| response to insulin | |
| drug metabolic process | |
| internal protein amino acid acetylation | |
| phosphorylation | |
| carbohydrate metabolic process | |
| glucose homeostasis |
| Pathway | Insulin Resistance in Hepatocytes |
|---|---|
| Role of Adiponectin in Insulin Resistance Prevention | |
| Proteins Involved in Pathogenesis of Diabetes Mellitus Type 2 | |
| Noradrenaline/Gs Expression Targets | |
| GCG Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| metformin-gene, gene-chemical, gene-gene interaction pathway | |
| New Pathway | |
| glycolysis/gluconeogenesis pathway | |
| gluconeogenesis pathway |
| Group | Tricarboxylic acid cycle |
|---|---|
| lipid metabolic process | |
| small molecule metabolic process | |
| glycerol biosynthetic process from pyruvate | |
| gluconeogenesis | |
| glucose metabolic process | |
| oxaloacetate metabolic process | |
| response to activity | |
| response to insulin | |
| lyase activity | |
| transferase activity | |
| kinase activity | |
| carboxy-lyase activity | |
| phosphoenolpyruvate carboxykinase activity | |
| phosphoenolpyruvate carboxykinase (GTP) activity | |
| drug metabolic process | |
| internal protein amino acid acetylation | |
| phosphorylation | |
| carbohydrate metabolic process | |
| glucose homeostasis | |
| nucleotide binding | |
| purine nucleotide binding | |
| GDP binding | |
| GTP binding | |
| carboxylic acid binding | |
| metal ion binding | |
| magnesium ion binding | |
| manganese ion binding | |
| cytoplasm | |
| cytosol |
| LocusLink ID | 5105 |
|---|---|
| 18534 | |
| 362282 |
| Cell Localization | Mitochondria |
|---|---|
| Cytoplasm |
| GO ID | 0019003 |
|---|---|
| 0005525 | |
| 0031406 | |
| 0000287 | |
| 0030145 | |
| 0004613 | |
| 0005975 | |
| 0017144 | |
| 0006094 | |
| 0042593 | |
| 0006006 | |
| 0046327 | |
| 0006475 | |
| 0006107 | |
| 0014823 | |
| 0032868 | |
| 0044281 | |
| 0005737 | |
| 0005829 | |
| 0016831 | |
| 0016301 | |
| 0016829 | |
| 0046872 | |
| 0000166 | |
| 0004611 | |
| 0017076 | |
| 0016740 | |
| 0006629 | |
| 0016310 | |
| 0005634 | |
| 0005625 |
| Alias | PEPCK1 |
|---|---|
| PEPCKC | |
| PEPCK-C | |
| phosphoenolpyruvate carboxykinase, cytosolic [GTP] | |
| PEP carboxykinase | |
| phosphopyruvate carboxylase | |
| phosphoenolpyruvate carboxylase | |
| phosphoenolpyruvate carboxykinase, cytosolic | |
| PEPCK | |
| Pck-1 | |
| AI265463 | |
| RP23-44L6.3 | |
| GTP | |
| PCK | |
| RATPEPCK | |
| phosphoenolpyruvate carboxykinase (GTP) | |
| phosphoenolpyruvate carboxykinase 1, cytosolic | |
| phosphoenolpyruvate carboxykinase, cytosolic (GTP) | |
| PEPCK-Cs | |
| phosphoenolpyruvate carboxykinase I | |
| phosphoenolpyruvate carboxykinase 1 | |
| phosphoenolpyruvate carboxykinase 1 (soluble) | |
| Phosphoenolpyruvate carboxylase 1 | |
| Phosphoenolpyruvate carboxylase I | |
| gAF1/PCK1 | |
| cytosolic phosphoenolpyruvate carboxykinase I | |
| cytosolic phosphoenolpyruvate carboxykinase 1 | |
| MGC93820 | |
| MGC22652 | |
| OTTHUMP00000031374 | |
| PCK I | |
| PCK1 | |
| PEP carboxykinase 1 | |
| PEPCK I | |
| OTTMUSP00000018058 | |
| cytosolic Phosphoenolpyruvate carboxykinase (GTP) | |
| PEPCK1s | |
| PEPCK Is | |
| expressed sequence AI265463 |
| Mouse chromosome position | 2 95.79 cM |
|---|---|
| 2 103.0 cM |
| OMIM ID | 614168 |
|---|---|
| 261680 |
| Rat chromosome position | 3q42 |
|---|
| Hugo ID | 8724 |
|---|
| Human chromosome position | 20q13.31 |
|---|
| Swiss-Prot Accession | P35558 |
|---|---|
| B4DT64 | |
| Q9Z2V4 | |
| P07379 | |
| Q3UEH3 | |
| A8K437 | |
| Q8TCA3 | |
| Q9UJD2 | |
| A2APF6 |
| PIR ID | A45746 |
|---|---|
| A23927 |
| Unigene ID | Hs.1872 |
|---|---|
| Mm.266867 | |
| Rn.104376 |
| KEGG ID | hsa:5105 |
|---|---|
| mmu:18534 | |
| rno:362282 |
| Swiss-Prot ID | PCKGC_MOUSE |
|---|---|
| PCKGC_HUMAN | |
| PCKGC_RAT |
| EC Number | 4.1.1.32 |
|---|
| Ensembl ID | ENSG00000124253 |
|---|---|
| ENSP00000319814 | |
| ENST00000319441 | |
| ENSMUSG00000027513 | |
| ENSMUSP00000029017 | |
| ENSMUST00000029017 | |
| ENSRNOG00000028616 | |
| ENSRNOP00000030913 | |
| ENSRNOT00000031586 |
| Homologene ID | 1944 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 97501 |
|---|
| RGD ID | 3267 |
|---|
| MedScan ID | 5105 |
|---|
| Primary Cell Localization | Mitochondria |
|---|
| IPI ID | IPI00395267 |
|---|---|
| IPI00292709 | |
| IPI00131438 |