| URN | urn:agi-llid:2597 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1898 |
| Name | GAPDH |
| Description | glyceraldehyde-3-phosphate dehydrogenase |
| Notes | Glyceraldehyde-3-phosphate dehydrogenase catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. A GAPD pseudogene has been mapped to Xp21-p11 and 15 GAPD-like loci have been identified. |
| GO Molecular Function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
|---|---|
| glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | |
| peptidyl-cysteine S-nitrosylase activity | |
| microtubule binding | |
| NAD binding | |
| NADP binding |
| GO Cellular Component | ribonucleoprotein complex |
|---|---|
| GAIT complex | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| perinuclear region of cytoplasm | |
| mitochondrion | |
| lipid particle | |
| microtubule cytoskeleton | |
| nucleus | |
| extracellular vesicular exosome |
| GO Biological Process | cellular response to interferon-gamma |
|---|---|
| small molecule metabolic process | |
| oxidation-reduction process | |
| gluconeogenesis | |
| glycolytic process | |
| glucose metabolic process | |
| multicellular organismal development | |
| microtubule cytoskeleton organization | |
| apoptotic process | |
| neuron apoptotic process | |
| response to ammonium ion | |
| negative regulation of translation | |
| regulation of translation | |
| protein stabilization | |
| peptidyl-cysteine S-nitrosylation | |
| peptidyl-cysteine S-trans-nitrosylation | |
| carbohydrate metabolic process |
| Pathway | Secretory Pathway: Golgi Transport |
|---|---|
| Proteins Involved in Pathogenesis of Alzheimer's Disease | |
| Proteins Involved in Pathogenesis of Parkinson's Disease | |
| Glycolysis | |
| Peripheral Tissue Microangiopathy in Insulin Resistance | |
| Proteins Involved in Pathogenesis of Myocardial Ischemia | |
| IL4 Expression Targets | |
| Leptin/ELK-SRF Expression Targets | |
| Leptin/STAT Expression Targets | |
| IGF1/STAT Expression Targets | |
| Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| Insulin/STAT Expression Targets | |
| IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| IGF1/MEF/MYOD/MYOG Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGF/STAT Expression Targets | |
| TLR4/AP-1/EGR1/HIF1A Expression Targets | |
| New Pathway | |
| glycolysis/gluconeogenesis pathway | |
| gluconeogenesis pathway | |
| glycolysis pathway |
| Group | Glucose metabolism |
|---|---|
| cellular response to interferon-gamma | |
| small molecule metabolic process | |
| oxidation-reduction process | |
| gluconeogenesis | |
| glycolytic process | |
| glucose metabolic process | |
| oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | |
| glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity | |
| multicellular organismal development | |
| microtubule cytoskeleton organization | |
| apoptotic process | |
| neuron apoptotic process | |
| response to ammonium ion | |
| negative regulation of translation | |
| regulation of translation | |
| protein stabilization | |
| peptidyl-cysteine S-nitrosylase activity | |
| peptidyl-cysteine S-nitrosylation | |
| peptidyl-cysteine S-trans-nitrosylation | |
| carbohydrate metabolic process | |
| microtubule binding | |
| NAD binding | |
| NADP binding | |
| ribonucleoprotein complex | |
| GAIT complex | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| perinuclear region of cytoplasm | |
| mitochondrion | |
| lipid particle | |
| microtubule cytoskeleton | |
| nucleus | |
| extracellular vesicular exosome | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 2597 |
|---|---|
| 14433 | |
| 100042025 | |
| 24383 | |
| 500983 | |
| 685186 | |
| 622339 | |
| 689689 |
| Cell Localization | Cytoplasm |
|---|---|
| Cytosol | |
| Nucleus | |
| Perinuclear region | |
| Membrane | |
| Cytoskeleton |
| GO ID | 0051287 |
|---|---|
| 0050661 | |
| 0004365 | |
| 0008017 | |
| 0035605 | |
| 0005975 | |
| 0071346 | |
| 0006094 | |
| 0006006 | |
| 0006096 | |
| 0000226 | |
| 0017148 | |
| 0051402 | |
| 0035606 | |
| 0050821 | |
| 0044281 | |
| 0097452 | |
| 0005737 | |
| 0005829 | |
| 0070062 | |
| 0005811 | |
| 0015630 | |
| 0005634 | |
| 0048471 | |
| 0005886 | |
| 0030529 | |
| 0007275 | |
| 0055114 | |
| 0018119 | |
| 0005739 | |
| 0006915 | |
| 0006417 | |
| 0060359 | |
| 0016620 | |
| 0005488 | |
| 0003824 | |
| 0016491 | |
| 0005515 | |
| 0008152 | |
| 0016020 | |
| 0008943 | |
| 0005625 |
| Alias | G3PD |
|---|---|
| GAPD | |
| CDABP0047 | |
| glyceraldehyde-3-phosphate dehydrogenase | |
| HEL-S-162eP | |
| aging-associated gene 9 protein | |
| peptidyl-cysteine S-nitrosylase GAPDH | |
| epididymis secretory sperm binding protein Li 162eP | |
| predicted gene, 20899 | |
| BARS-38 | |
| 38 kDa BFA-dependent ADP-ribosylation substrate | |
| similar to glyceraldehyde-3-phosphate dehydrogenase | |
| LOC100041399 | |
| LOC100041204 | |
| LOC100040053 | |
| LOC100043724 | |
| LOC100040109 | |
| LOC100041236 | |
| MGC102546 | |
| LOC100041325 | |
| LOC100039840 | |
| MGC103191 | |
| MGC102544 | |
| OTTMUSP00000005412 | |
| LOC100039762 | |
| LOC100039214 | |
| OTTMUSP00000033702 | |
| OTTMUSP00000033701 | |
| MGC103190 | |
| MGC105239 | |
| LOC100042025 | |
| Gm20899 | |
| LOC300651 | |
| ageing-associated protein 9 | |
| LOC100042427 | |
| Gapdh | |
| LOC689689 | |
| ageing-associated gene 9 | |
| aging-associated gene 9 | |
| glyceraldehyde 3-phosphate dehydrogenase | |
| glyceraldehyde 3-phosphate dehydrogenase (Cavia porcellus) | |
| Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) | |
| glyceraldehyde 3-phosphate dehydrogenase (Oncorhynchus mykiss) | |
| Glyceraldehyde 3-phosphate dehydrogenase, liver | |
| glyceraldehyde-3-phosphate dehydrogenase (Meriones unguiculatus) | |
| MGC88685 | |
| glyceraldehyde-3-phosphate dehydrogenase type B | |
| OTTHUMP00000174434 | |
| OTTHUMP00000174432 | |
| OTTHUMP00000174431 | |
| RGD1565368 | |
| LOC685186 | |
| aging-associated protein 9 | |
| LOC298258 | |
| LOC14433 | |
| predicted gene, EG622339 | |
| similar to glyceraldehyde-3-phosphate dehydrogenase (predicted) |
| Mouse chromosome position | 6 59.32 cM |
|---|---|
| Y | |
| 12 C2 |
| OMIM ID | 138400 |
|---|
| Rat chromosome position | 4q42 |
|---|---|
| 8q22 | |
| 5q33 | |
| 16p13 |
| Hugo ID | 4141 |
|---|
| Human chromosome position | 12p13 |
|---|
| Swiss-Prot Accession | P04406 |
|---|---|
| D2KHZ9 | |
| P16858 | |
| P04797 | |
| M0R660 | |
| M0R590 | |
| E7EUT4 | |
| P00354 | |
| Q53X65 | |
| A6H6A8 | |
| Q0QEU0 | |
| Q3THM2 | |
| Q3TUI2 | |
| Q3UMT2 | |
| Q4V783 | |
| Q569X2 | |
| Q569X5 | |
| Q5U410 | |
| P09328 | |
| Q5M916 | |
| Q9QWU4 |
| PIR ID | A31988 |
|---|---|
| JT0553 | |
| A23013 |
| Unigene ID | Hs.544577 |
|---|---|
| Hs.592355 | |
| Hs.598320 | |
| Mm.304088 | |
| Mm.309092 | |
| Mm.317779 | |
| Mm.343110 | |
| Mm.392463 | |
| Mm.458138 | |
| Mm.458416 | |
| Rn.91450 | |
| Rn.129558 | |
| Mm.26381 | |
| Rn.217843 |
| KEGG ID | hsa:2597 |
|---|---|
| mmu:14433 | |
| mmu:100042025 | |
| rno:24383 | |
| rno:500983 | |
| rno:685186 | |
| mmu:622339 | |
| rno:689689 |
| Swiss-Prot ID | G3P_HUMAN |
|---|---|
| G3P_MOUSE | |
| G3P_RAT |
| EC Number | 1.2.1.12 |
|---|---|
| 2.6.99.- |
| Ensembl ID | ENSG00000111640 |
|---|---|
| ENSP00000380067 | |
| ENST00000396858 | |
| ENSP00000380070 | |
| ENST00000396861 | |
| ENSP00000380065 | |
| ENST00000396856 | |
| ENSMUSG00000057666 | |
| ENSMUSP00000113213 | |
| ENSMUST00000118875 | |
| ENSRNOG00000018630 | |
| ENSRNOP00000040878 | |
| ENSRNOT00000050443 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 95640 |
|---|---|
| 5434255 | |
| 3646088 |
| RGD ID | 2661 |
|---|---|
| 1565368 | |
| 1597697 | |
| 1589889 |
| MedScan ID | 2597 |
|---|