| URN | urn:agi-llid:7167 |
|---|---|
| Total Entities | 0 |
| Connectivity | 304 |
| Name | TPI1 |
| Description | triosephosphate isomerase 1 |
| Notes | This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] |
| GO Molecular Function | catalytic activity |
|---|---|
| isomerase activity | |
| triose-phosphate isomerase activity |
| GO Cellular Component | cytosol |
|---|
| GO Biological Process | metabolic process |
|---|---|
| small molecule metabolic process | |
| gluconeogenesis | |
| glycolytic process | |
| pentose-phosphate shunt | |
| glucose metabolic process | |
| glyceraldehyde-3-phosphate metabolic process | |
| multicellular organismal development | |
| embryo development | |
| carbohydrate metabolic process |
| Pathway | Glycolysis |
|---|---|
| New Pathway | |
| glycolysis/gluconeogenesis pathway | |
| gluconeogenesis pathway | |
| glycolysis pathway |
| Group | Glucose metabolism |
|---|---|
| metabolic process | |
| small molecule metabolic process | |
| gluconeogenesis | |
| glycolytic process | |
| pentose-phosphate shunt | |
| glucose metabolic process | |
| glyceraldehyde-3-phosphate metabolic process | |
| multicellular organismal development | |
| embryo development | |
| catalytic activity | |
| isomerase activity | |
| triose-phosphate isomerase activity | |
| carbohydrate metabolic process | |
| cytosol | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 7167 |
|---|---|
| 21991 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0004807 |
|---|---|
| 0005975 | |
| 0009790 | |
| 0006094 | |
| 0006006 | |
| 0019682 | |
| 0006096 | |
| 0006098 | |
| 0044281 | |
| 0005829 | |
| 0003824 | |
| 0016853 | |
| 0008152 | |
| 0007275 | |
| 0006633 | |
| 0008610 |
| Alias | TIM |
|---|---|
| TPI | |
| TPID | |
| HEL-S-49 | |
| triosephosphate isomerase | |
| triose-phosphate isomerase | |
| epididymis secretory protein Li 49 | |
| Tpi-1 | |
| AI255506 | |
| Tpi1 | |
| Triosephosphate isomerase I | |
| Triosephosphate isomerase 1 | |
| MGC156639 | |
| LOC121572 | |
| MGC88108 | |
| OTTHUMP00000165244 | |
| OTTMUSP00000019147 | |
| TPI I | |
| TRIOSEPHOSPHATE ISOMERASE (TIM) |
| Mouse chromosome position | 6 59.17 cM |
|---|---|
| 6 60.2 cM |
| OMIM ID | 190450 |
|---|---|
| 615512 |
| Hugo ID | 12009 |
|---|
| Human chromosome position | 12p13 |
|---|
| Swiss-Prot Accession | P60174 |
|---|---|
| Q53HE2 | |
| P17751 | |
| Q3TJH2 | |
| Q3UC04 | |
| Q3UKG9 | |
| Q64513 | |
| Q9CVF9 | |
| Q9CWE7 | |
| B7Z5D8 | |
| D3DUS9 | |
| P00938 | |
| Q6FHP9 | |
| Q6IS07 | |
| Q8WWD0 | |
| Q96AG5 |
| PIR ID | S10490 |
|---|---|
| S29743 |
| Unigene ID | Hs.524219 |
|---|---|
| Mm.4222 | |
| Mm.439915 |
| KEGG ID | hsa:7167 |
|---|---|
| mmu:21991 |
| Swiss-Prot ID | TPIS_MOUSE |
|---|---|
| TPIS_HUMAN |
| EC Number | 5.3.1.1 |
|---|
| Ensembl ID | ENSG00000111669 |
|---|---|
| ENSP00000379933 | |
| ENST00000396705 | |
| ENSP00000229270 | |
| ENST00000229270 | |
| ENSP00000443599 | |
| ENST00000535434 | |
| ENSMUSG00000023456 | |
| ENSMUSP00000130858 | |
| ENSMUST00000172132 |
| Homologene ID | 128432 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| MGI ID | 98797 |
|---|
| RGD ID | 3896 |
|---|
| MedScan ID | 7167 |
|---|