| URN | urn:agi-llid:7167 |
|---|---|
| Connectivity | 65 |
| Name | Tpi1 |
| Description | triosephosphate isomerase 1 |
| Notes | This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq] |
| Pathway | New Pathway |
|---|---|
| glycolysis/gluconeogenesis pathway | |
| gluconeogenesis pathway | |
| glycolysis pathway |
| GO Molecular Function | catalytic activity |
|---|---|
| isomerase activity | |
| triose-phosphate isomerase activity |
| GO Cellular Component | soluble fraction |
|---|---|
| cytosol | |
| nucleus |
| GO Biological Process | metabolic process |
|---|---|
| multicellular organismal development | |
| embryonic development | |
| glycolysis | |
| glyceraldehyde-3-phosphate metabolic process | |
| gluconeogenesis | |
| fatty acid biosynthetic process | |
| glucose metabolic process | |
| pentose-phosphate shunt | |
| carbohydrate metabolic process | |
| lipid biosynthetic process |
| Ariadne Ontology | Glucose metabolism |
|---|
| Group | Glucose metabolism |
|---|---|
| catalytic activity | |
| metabolic process | |
| multicellular organismal development | |
| embryonic development | |
| glycolysis | |
| glyceraldehyde-3-phosphate metabolic process | |
| gluconeogenesis | |
| fatty acid biosynthetic process | |
| glucose metabolic process | |
| pentose-phosphate shunt | |
| carbohydrate metabolic process | |
| lipid biosynthetic process | |
| isomerase activity | |
| triose-phosphate isomerase activity | |
| soluble fraction | |
| cytosol | |
| nucleus |
| MedScan ID | 7167 |
|---|
| Hugo ID | 12009 |
|---|
| Human chromosome position | 12p13 |
|---|
| LocusLink ID | 7167 |
|---|---|
| 21991 | |
| 24849 | |
| 498731 | |
| 500959 |
| Alias | TPI |
|---|---|
| MGC88108 | |
| triosephosphate isomerase | |
| TIM | |
| OTTHUMP00000165244 | |
| triose-phosphate isomerase | |
| Tpi-1 | |
| AI255506 | |
| OTTMUSP00000019147 | |
| MGC156639 | |
| similar to Tpi1 protein | |
| LOC121572 | |
| LOC291063 | |
| LOC300465 | |
| LOC500959 | |
| RGD1563601 | |
| TPI I | |
| TPI1 | |
| Triosephosphate isomerase 1 | |
| Triosephosphate isomerase I | |
| TRIOSEPHOSPHATE ISOMERASE (TIM) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 190450 |
|---|
| Mouse chromosome position | 6 60.2 cM |
|---|
| GO ID | 0016853 |
|---|---|
| 0004807 | |
| 0005975 | |
| 0009790 | |
| 0006633 | |
| 0006094 | |
| 0019682 | |
| 0006096 | |
| 0008152 | |
| 0006098 | |
| 0005829 | |
| 0005634 | |
| 0005625 | |
| 0003824 | |
| 0006006 | |
| 0008610 | |
| 0007275 |
| Rat chromosome position | 4q42 |
|---|---|
| 17p12 | |
| 8q13 |
| Swiss-Prot Accession | P60174 |
|---|---|
| Q53HE2 | |
| P17751 | |
| P48500 | |
| Q6SA19 | |
| A0JN18 | |
| Q6P793 | |
| P00938 | |
| Q6FHP9 | |
| Q6IS07 | |
| Q8WWD0 | |
| Q96AG5 | |
| Q3TJH2 | |
| Q3UC04 | |
| Q3UKG9 | |
| Q64513 | |
| Q9CVF9 | |
| Q9CWE7 | |
| D3DUS9 |
| PIR ID | S29743 |
|---|---|
| S10490 |
| Unigene ID | Hs.524219 |
|---|---|
| Mm.4222 | |
| Mm.391520 | |
| Mm.439915 | |
| Rn.37838 | |
| Rn.144555 | |
| Rn.129979 |
| KEGG ID | hsa:7167 |
|---|---|
| mmu:21991 | |
| rno:24849 | |
| rno:498731 | |
| rno:500959 |
| EC Number | 5.3.1.1 |
|---|
| Swiss-Prot ID | TPIS_RAT |
|---|---|
| TPIS_HUMAN | |
| TPIS_MOUSE | |
| Q6SA19_RAT | |
| D3DUS9_HUMAN | |
| Q53HE2_HUMAN | |
| Q6FHP9_HUMAN |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00231767 |
|---|---|
| IPI00451401 | |
| IPI00797270 | |
| IPI00467833 | |
| IPI00421392 | |
| IPI00465028 | |
| IPI00788640 | |
| IPI00796633 | |
| IPI00765670 | |
| IPI00339162 | |
| IPI00764805 | |
| IPI00769156 |
| Homologene ID | 100531 |
|---|
| RGD ID | 3896 |
|---|---|
| 1563601 | |
| 1560534 |
| MGI ID | 98797 |
|---|