| URN | urn:agi-llid:2538 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1001 |
| Name | G6PC |
| Description | glucose-6-phosphatase, catalytic subunit |
| Notes | Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I (von Gierke disease). |
| GO Molecular Function | primary amine oxidase activity |
|---|---|
| catalytic activity | |
| hydrolase activity | |
| phosphotransferase activity, alcohol group as acceptor | |
| peptidase activity | |
| glucose-6-phosphatase activity | |
| quinone binding | |
| phosphate ion binding | |
| copper ion binding |
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| endoplasmic reticulum membrane | |
| integral component of endoplasmic reticulum membrane | |
| proteasome activator complex | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle |
| GO Biological Process | small molecule metabolic process |
|---|---|
| gluconeogenesis | |
| glycogen catabolic process | |
| glycogen metabolic process | |
| steroid metabolic process | |
| triglyceride metabolic process | |
| urate metabolic process | |
| multicellular organism growth | |
| transmembrane transport | |
| glucose-6-phosphate transport | |
| hexose transport | |
| glucose transport | |
| response to food | |
| regulation of gene expression | |
| phosphorylated carbohydrate dephosphorylation | |
| phosphate-containing compound metabolic process | |
| dephosphorylation | |
| glucose 6-phosphate metabolic process | |
| carbohydrate metabolic process | |
| proteolysis | |
| amine metabolic process | |
| lipid homeostasis | |
| cholesterol homeostasis | |
| glucose homeostasis |
| Pathway | Insulin Resistance in Hepatocytes |
|---|---|
| Role of Adiponectin in Insulin Resistance Prevention | |
| Proteins Involved in Pathogenesis of Diabetes Mellitus Type 2 | |
| Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| Insulin/STAT Expression Targets | |
| TNF/NF-kB Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| New Pathway | |
| glycolysis/gluconeogenesis pathway | |
| gluconeogenesis pathway | |
| glycogen degradation pathway |
| Group | Glucose metabolism |
|---|---|
| small molecule metabolic process | |
| gluconeogenesis | |
| glycogen catabolic process | |
| glycogen metabolic process | |
| primary amine oxidase activity | |
| steroid metabolic process | |
| triglyceride metabolic process | |
| urate metabolic process | |
| multicellular organism growth | |
| transmembrane transport | |
| glucose-6-phosphate transport | |
| hexose transport | |
| glucose transport | |
| response to food | |
| regulation of gene expression | |
| catalytic activity | |
| hydrolase activity | |
| phosphotransferase activity, alcohol group as acceptor | |
| peptidase activity | |
| glucose-6-phosphatase activity | |
| phosphorylated carbohydrate dephosphorylation | |
| phosphate-containing compound metabolic process | |
| dephosphorylation | |
| glucose 6-phosphate metabolic process | |
| carbohydrate metabolic process | |
| proteolysis | |
| amine metabolic process | |
| lipid homeostasis | |
| cholesterol homeostasis | |
| glucose homeostasis | |
| quinone binding | |
| phosphate ion binding | |
| copper ion binding | |
| membrane | |
| integral component of membrane | |
| endoplasmic reticulum membrane | |
| integral component of endoplasmic reticulum membrane | |
| proteasome activator complex | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 2538 |
|---|---|
| 14377 | |
| 25634 |
| Cell Localization | Cytoplasm |
|---|---|
| Endoplasmic reticulum membrane |
| GO ID | 0004346 |
|---|---|
| 0042301 | |
| 0016773 | |
| 0005975 | |
| 0042632 | |
| 0006094 | |
| 0051156 | |
| 0042593 | |
| 0015758 | |
| 0015760 | |
| 0005980 | |
| 0005977 | |
| 0008645 | |
| 0035264 | |
| 0010468 | |
| 0044281 | |
| 0008202 | |
| 0055085 | |
| 0006641 | |
| 0046415 | |
| 0005789 | |
| 0030176 | |
| 0016021 | |
| 0003824 | |
| 0016787 | |
| 0016311 | |
| 0055088 | |
| 0006796 | |
| 0046838 | |
| 0005783 | |
| 0043231 | |
| 0016020 | |
| 0005507 | |
| 0008233 | |
| 0008131 | |
| 0048038 | |
| 0009308 | |
| 0006508 | |
| 0032094 | |
| 0008537 | |
| 0005978 | |
| 0005792 |
| Alias | G6PT |
|---|---|
| GSD1 | |
| G6PC1 | |
| GSD1a | |
| glucose-6-phosphatase | |
| G6Pase | |
| G-6-Pase | |
| G6Pase-alpha | |
| glucose-6-phosphatase alpha | |
| AW107337 | |
| Glc-6-Pase | |
| RP23-281C18.19-001 | |
| Glc-6-Pase-alpha | |
| glycogen storage disease type 1 gene | |
| MGC93613 | |
| OTTMUSP00000002712 | |
| MGC163350 | |
| RP23-281C18.19 | |
| glycogen storage disease type 1 protein | |
| glycogen storage disease type I gene | |
| glycogen storage disease type I protein | |
| von gierke disease protein | |
| glycogen storage disease type I, von Gierke disease gene | |
| von gierke disease gene | |
| glucose-6-phosphatase, catalytic subunit | |
| catalytic glucose-6-phosphatase | |
| cDNA sequence BC056485 | |
| G6pc | |
| Glucose-6-phosphatase, catalytic | |
| glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gierke disease) | |
| glycogen storage disease type I, von Gierke disease | |
| BC056485 | |
| hypothetical protein B430319G23 | |
| radical s-adenosyl methionine domain containing 1 | |
| radical s-adenosyl methionine domain containing I | |
| rp23-402d13.3 | |
| rsad1 | |
| B430319G23 | |
| hypothetical protein FLJ11164 | |
| glucose-6-phosphatase, catalytic (glycogen storage disease type I, von Gier | |
| FLJ11164 | |
| glycogen storage disease type 1 | |
| glycogen storage disease type I | |
| von gierke disease) |
| Mouse chromosome position | 11 |
|---|---|
| 11 D |
| OMIM ID | 613742 |
|---|---|
| 232200 |
| Rat chromosome position | 10q32.1 |
|---|
| Hugo ID | 4056 |
|---|
| Human chromosome position | 17q21 |
|---|
| Swiss-Prot Accession | P35575 |
|---|---|
| P35576 | |
| P43428 | |
| Q5FVC9 | |
| A1L4C0 | |
| B4E1C3 | |
| K7EL82 | |
| Q91WV3 |
| PIR ID | JC2371 |
|---|---|
| A48251 | |
| A48589 |
| Unigene ID | Hs.212293 |
|---|---|
| Hs.742566 | |
| Mm.18064 | |
| Rn.10992 |
| KEGG ID | hsa:2538 |
|---|---|
| mmu:14377 | |
| rno:25634 |
| Swiss-Prot ID | G6PC_RAT |
|---|---|
| G6PC_HUMAN | |
| G6PC_MOUSE |
| EC Number | 3.1.3.9 |
|---|
| Ensembl ID | ENSMUSG00000078650 |
|---|---|
| ENSMUSP00000019469 | |
| ENSMUST00000019469 | |
| ENSRNOG00000036806 | |
| ENSRNOP00000028033 | |
| ENSRNOT00000028033 |
| Homologene ID | 20079 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 95607 |
|---|
| RGD ID | 2644 |
|---|
| MedScan ID | 2538 |
|---|