| URN | urn:agi-llid:2203 |
|---|---|
| Total Entities | 0 |
| Connectivity | 431 |
| Name | FBP1 |
| Description | fructose-1,6-bisphosphatase 1 |
| Notes | Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. |
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| phosphoric ester hydrolase activity | |
| fructose 1,6-bisphosphate 1-phosphatase activity | |
| AMP binding | |
| monosaccharide binding | |
| metal ion binding |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol |
| GO Biological Process | metabolic process |
|---|---|
| small molecule metabolic process | |
| regulation of gluconeogenesis | |
| gluconeogenesis | |
| negative regulation of glycolytic process | |
| glucose metabolic process | |
| fructose metabolic process | |
| negative regulation of Ras protein signal transduction | |
| negative regulation of cell growth | |
| cellular response to insulin stimulus | |
| cellular response to magnesium ion | |
| cellular response to drug | |
| fructose 6-phosphate metabolic process | |
| dephosphorylation | |
| carbohydrate metabolic process | |
| protein homotetramerization |
| Pathway | New Pathway |
|---|---|
| glycolysis/gluconeogenesis pathway | |
| gluconeogenesis pathway |
| Group | Glucose metabolism |
|---|---|
| Pentose-phosphate shunt | |
| metabolic process | |
| small molecule metabolic process | |
| regulation of gluconeogenesis | |
| gluconeogenesis | |
| negative regulation of glycolytic process | |
| glucose metabolic process | |
| fructose metabolic process | |
| negative regulation of Ras protein signal transduction | |
| negative regulation of cell growth | |
| cellular response to insulin stimulus | |
| cellular response to magnesium ion | |
| cellular response to drug | |
| catalytic activity | |
| hydrolase activity | |
| phosphoric ester hydrolase activity | |
| fructose 1,6-bisphosphate 1-phosphatase activity | |
| fructose 6-phosphate metabolic process | |
| dephosphorylation | |
| carbohydrate metabolic process | |
| protein homotetramerization | |
| AMP binding | |
| monosaccharide binding | |
| metal ion binding | |
| cytoplasm | |
| cytosol | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 2203 |
|---|---|
| 14121 | |
| 24362 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0016208 |
|---|---|
| 0042132 | |
| 0046872 | |
| 0048029 | |
| 0005975 | |
| 0035690 | |
| 0071286 | |
| 0016311 | |
| 0006002 | |
| 0006000 | |
| 0006094 | |
| 0006006 | |
| 0046580 | |
| 0030308 | |
| 0045820 | |
| 0051289 | |
| 0006111 | |
| 0044281 | |
| 0005737 | |
| 0005829 | |
| 0003824 | |
| 0016787 | |
| 0042578 | |
| 0008152 | |
| 0032869 | |
| 0004331 | |
| 0042802 | |
| 0008270 | |
| 0005625 |
| Alias | FBP |
|---|---|
| RP11-342C23.1 | |
| fructose-1,6-bisphosphatase 1 | |
| FBPase 1 | |
| fructose-bisphosphatase 1 | |
| growth-inhibiting protein 17 | |
| D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | |
| Fbp2 | |
| Fbp3 | |
| Fbp-2 | |
| FBPase liver | |
| FBPase brain isoform | |
| fructose-1,6-bisphosphatase isozyme 3 | |
| D-fructose-1,6-bisphosphate 1-phosphohydrolase 3 | |
| Fdp | |
| Fructose-16- biphosphatase | |
| fructose-1,6- biphosphatase 1 | |
| fructose-1,6- biphosphatase I | |
| Fructose-1,6-bisphosphatase | |
| fructose-1,6-bisphosphatase I | |
| fructose-16-bisphosphatase 1 | |
| fructose-16-bisphosphatase I | |
| liver FBPase | |
| liver fructose-bisphosphatase | |
| OTTHUMP00000021694 | |
| fructose bisphosphatase I | |
| LOC116309 | |
| fructose bisphosphatase III | |
| FBP I | |
| FBP1 | |
| FBPase | |
| FBPase I | |
| FDPase 1 | |
| FDPase I | |
| fructose bisphosphatase 1 | |
| fructose bisphosphatase 3 | |
| FBPase 3 | |
| D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 |
| Mouse chromosome position | 13 |
|---|---|
| 13 B3-C1 |
| OMIM ID | 611570 |
|---|---|
| 229700 |
| Rat chromosome position | 17p14 |
|---|
| Hugo ID | 3606 |
|---|
| Human chromosome position | 9q22.3 |
|---|
| Swiss-Prot Accession | P09467 |
|---|---|
| Q2TU34 | |
| Q9QXD6 | |
| P97323 | |
| P19112 | |
| Q64594 | |
| Q3UEH1 | |
| O75571 | |
| Q53F94 | |
| Q96E46 |
| PIR ID | A31342 |
|---|---|
| A46666 |
| Unigene ID | Hs.494496 |
|---|---|
| Mm.423078 | |
| Rn.33703 |
| KEGG ID | hsa:2203 |
|---|---|
| mmu:14121 | |
| rno:24362 |
| Swiss-Prot ID | F16P1_RAT |
|---|---|
| F16P1_MOUSE | |
| F16P1_HUMAN |
| EC Number | 3.1.3.11 |
|---|
| Ensembl ID | ENSG00000165140 |
|---|---|
| ENSP00000364475 | |
| ENST00000375326 | |
| ENSP00000408025 | |
| ENST00000415431 | |
| ENSMUSG00000069805 | |
| ENSMUSP00000090564 | |
| ENSMUST00000092888 |
| Homologene ID | 55467 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 95492 |
|---|
| RGD ID | 2595 |
|---|
| MedScan ID | 2203 |
|---|