| URN | urn:agi-llid:5105 |
|---|---|
| Connectivity | 136 |
| Name | Pck1 |
| Description | phosphoenolpyruvate carboxykinase 1 (soluble) |
| Notes | This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. A mitochondrial isozyme of the encoded protein also has been characterized. |
| Pathway | New Pathway |
|---|---|
| glycolysis/gluconeogenesis pathway | |
| gluconeogenesis pathway |
| GO Molecular Function | carboxylic acid binding |
|---|---|
| nucleotide binding | |
| lyase activity | |
| purine nucleotide binding | |
| GDP binding | |
| GTP binding | |
| metal ion binding | |
| magnesium ion binding | |
| manganese ion binding | |
| kinase activity | |
| carboxy-lyase activity | |
| phosphoenolpyruvate carboxykinase activity | |
| phosphoenolpyruvate carboxykinase (GTP) activity |
| GO Cellular Component | soluble fraction |
|---|---|
| cytoplasm | |
| cytosol | |
| centrosome | |
| nucleolus | |
| nucleus |
| GO Biological Process | response to activity |
|---|---|
| glycerol biosynthetic process from pyruvate | |
| gluconeogenesis | |
| glucose metabolic process | |
| oxaloacetate metabolic process | |
| response to insulin stimulus | |
| lipid metabolic process | |
| glucose homeostasis |
| Ariadne Ontology | Tricarboxylic acid cycle |
|---|
| Group | Tricarboxylic acid cycle |
|---|---|
| response to activity | |
| glycerol biosynthetic process from pyruvate | |
| gluconeogenesis | |
| glucose metabolic process | |
| oxaloacetate metabolic process | |
| response to insulin stimulus | |
| lipid metabolic process | |
| glucose homeostasis | |
| carboxylic acid binding | |
| nucleotide binding | |
| lyase activity | |
| purine nucleotide binding | |
| GDP binding | |
| GTP binding | |
| metal ion binding | |
| magnesium ion binding | |
| manganese ion binding | |
| kinase activity | |
| carboxy-lyase activity | |
| phosphoenolpyruvate carboxykinase activity | |
| phosphoenolpyruvate carboxykinase (GTP) activity | |
| soluble fraction | |
| cytoplasm | |
| cytosol | |
| centrosome | |
| nucleolus | |
| nucleus |
| MedScan ID | 5105 |
|---|
| Hugo ID | 8724 |
|---|
| Human chromosome position | 20q13.31 |
|---|
| LocusLink ID | 5105 |
|---|---|
| 18534 | |
| 362282 |
| Alias | PEPCK1 |
|---|---|
| PEPCKC | |
| PEPCK-C | |
| MGC22652 | |
| phosphoenolpyruvate carboxykinase, cytosolic [GTP] | |
| PEP carboxykinase | |
| phosphopyruvate carboxylase | |
| phosphoenolpyruvate carboxylase | |
| phosphoenolpyruvate carboxykinase, cytosolic | |
| PEPCK | |
| Pck-1 | |
| AI265463 | |
| RP23-44L6.3 | |
| OTTMUSP00000018058 | |
| GTP | |
| PCK | |
| MGC93820 | |
| RATPEPCK | |
| phosphoenolpyruvate carboxykinase (GTP) | |
| phosphoenolpyruvate carboxykinase 1, cytosolic | |
| phosphoenolpyruvate carboxykinase, cytosolic (GTP) | |
| cytosolic Phosphoenolpyruvate carboxykinase (GTP) | |
| cytosolic phosphoenolpyruvate carboxykinase 1 | |
| cytosolic phosphoenolpyruvate carboxykinase I | |
| gAF1/PCK1 | |
| OTTHUMP00000031374 | |
| PCK I | |
| PCK1 | |
| PEPCK I | |
| PEPCK-Cs | |
| phosphoenolpyruvate carboxykinase 1 | |
| phosphoenolpyruvate carboxykinase 1 (soluble) | |
| phosphoenolpyruvate carboxykinase I | |
| Phosphoenolpyruvate carboxylase 1 | |
| Phosphoenolpyruvate carboxylase I | |
| Phosphoenolpyruvate carboxykinase | |
| PEPCK1s | |
| PEPCK Is | |
| expressed sequence AI265463 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 261680 |
|---|
| Mouse chromosome position | 2 103.0 cM |
|---|
| GO ID | 0019003 |
|---|---|
| 0005525 | |
| 0031406 | |
| 0016829 | |
| 0000287 | |
| 0030145 | |
| 0004613 | |
| 0017076 | |
| 0006094 | |
| 0042593 | |
| 0006006 | |
| 0046327 | |
| 0006629 | |
| 0006107 | |
| 0014823 | |
| 0032868 | |
| 0005737 | |
| 0005829 | |
| 0005730 | |
| 0005634 | |
| 0005625 | |
| 0016831 | |
| 0016301 | |
| 0046872 | |
| 0000166 | |
| 0004611 | |
| 0005813 |
| Rat chromosome position | 3q42 |
|---|
| Swiss-Prot Accession | P35558 |
|---|---|
| A2APF6 | |
| Q9Z2V4 | |
| Q8BSX3 | |
| Q8CI37 | |
| P07379 | |
| A8K437 | |
| Q8TCA3 | |
| Q9UJD2 | |
| Q3UEH3 |
| PIR ID | A23927 |
|---|---|
| A45746 |
| Unigene ID | Hs.1872 |
|---|---|
| Mm.479876 | |
| Rn.104376 | |
| Mm.477474 | |
| Mm.266867 |
| KEGG ID | hsa:5105 |
|---|---|
| mmu:18534 | |
| rno:362282 |
| EC Number | 4.1.1.32 |
|---|
| Swiss-Prot ID | PCKGC_RAT |
|---|---|
| PCKGC_HUMAN | |
| PCKGC_MOUSE | |
| A2APF6_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Mitochondria |
| IPI ID | IPI00395267 |
|---|---|
| IPI00292709 | |
| IPI00131438 |
| Homologene ID | 1944 |
|---|
| RGD ID | 3267 |
|---|
| MGI ID | 97501 |
|---|