| URN | urn:agi-llid:2821 |
|---|---|
| Connectivity | 151 |
| Name | Gpi |
| Description | glucose phosphate isomerase |
| Notes | This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. |
| Pathway | New Pathway |
|---|---|
| glycolysis/gluconeogenesis pathway | |
| gluconeogenesis pathway | |
| glycolysis pathway |
| GO Molecular Function | isomerase activity |
|---|---|
| cytokine activity | |
| growth factor activity | |
| monosaccharide binding | |
| intramolecular transferase activity | |
| glucose-6-phosphate isomerase activity |
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space | |
| soluble fraction | |
| cytoplasm | |
| cytosol | |
| synaptosome |
| GO Biological Process | angiogenesis |
|---|---|
| hemostasis | |
| learning or memory | |
| negative regulation of neuron apoptosis | |
| negative regulation of caspase activity | |
| glycolysis | |
| aldehyde catabolic process | |
| methylglyoxal biosynthetic process | |
| gluconeogenesis | |
| glucose metabolic process | |
| glucose 6-phosphate metabolic process | |
| humoral immune response | |
| carbohydrate metabolic process |
| Ariadne Ontology | Pentose-phosphate shunt |
|---|---|
| Glucose metabolism |
| Group | Pentose-phosphate shunt |
|---|---|
| Glucose metabolism | |
| extracellular region | |
| angiogenesis | |
| hemostasis | |
| learning or memory | |
| negative regulation of neuron apoptosis | |
| negative regulation of caspase activity | |
| glycolysis | |
| aldehyde catabolic process | |
| methylglyoxal biosynthetic process | |
| gluconeogenesis | |
| glucose metabolic process | |
| glucose 6-phosphate metabolic process | |
| humoral immune response | |
| carbohydrate metabolic process | |
| isomerase activity | |
| cytokine activity | |
| growth factor activity | |
| monosaccharide binding | |
| intramolecular transferase activity | |
| glucose-6-phosphate isomerase activity | |
| extracellular space | |
| soluble fraction | |
| cytoplasm | |
| cytosol | |
| synaptosome |
| MedScan ID | 2821 |
|---|
| Hugo ID | 4458 |
|---|
| Human chromosome position | 19q13.1 |
|---|
| LocusLink ID | 2821 |
|---|---|
| 14751 | |
| 292804 |
| Alias | AMF |
|---|---|
| NLK | |
| PGI | |
| PHI | |
| GNPI | |
| SA36 | |
| SA-36 | |
| DKFZp686C13233 | |
| glucose-6-phosphate isomerase | |
| neuroleukin | |
| oxoisomerase | |
| sperm antigen 36 | |
| sperm antigen-36 | |
| phosphohexomutase | |
| phosphosaccharomutase | |
| phosphohexose isomerase | |
| phosphoglucose isomerase | |
| autocrine motility factor | |
| hexosephosphate isomerase | |
| glucose phosphate isomerase | |
| hexose monophosphate isomerase | |
| MF | |
| NK | |
| Gpi | |
| Org | |
| Gpi-1 | |
| Gpi1s | |
| Gpi-1r | |
| Gpi-1s | |
| Gpi-1t | |
| Gpi1-r | |
| Gpi1-s | |
| Gpi1-t | |
| NK/GPI | |
| MGC113776 | |
| RP23-349I9.4 | |
| maturation factor | |
| OTTMUSP00000008735 | |
| glucose phosphate isomerase 1 complex | |
| glucose phosphate isomerase 1, temporal | |
| structural glucose phosphate isomerase 1 | |
| glucose phosphate isomerase 1, regulatory | |
| glucose phosphate isomerase 1, structural | |
| Gpi1 | |
| glucose phosphate isomerase 1 | |
| glucose phosphate isomerase I | |
| glucose phosphohexomutase | |
| glucose-6-phosphate isomerase (EC 5.3.1.9) | |
| Gpi-1rs | |
| Gpi-1ss | |
| Gpi-1ts | |
| PGI/NLK/AMF | |
| structural glucose phosphate isomerase I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 172400 |
|---|
| Mouse chromosome position | 7 11.0 cM |
|---|
| GO ID | 0005125 |
|---|---|
| 0004347 | |
| 0008083 | |
| 0016853 | |
| 0001525 | |
| 0005975 | |
| 0006094 | |
| 0006096 | |
| 0007599 | |
| 0006959 | |
| 0005737 | |
| 0005576 | |
| 0005615 | |
| 0016866 | |
| 0048029 | |
| 0046185 | |
| 0051156 | |
| 0006006 | |
| 0019242 | |
| 0043154 | |
| 0043524 | |
| 0005829 | |
| 0005625 | |
| 0019717 | |
| 0007611 | |
| 0005515 | |
| 0007399 |
| Rat chromosome position | 1q21 |
|---|
| Swiss-Prot Accession | P06744 |
|---|---|
| Q59F85 | |
| P06745 | |
| Q6P6V0 | |
| O89062 | |
| Q3TEE7 | |
| Q3TW50 | |
| Q3UUX1 | |
| Q3UY84 | |
| Q3UZJ1 | |
| Q5RJI3 | |
| Q8C675 | |
| Q9JM07 | |
| Q9BRD3 | |
| Q9BSK5 | |
| Q9UHE6 |
| PIR ID | A24439 |
|---|---|
| A35333 |
| Unigene ID | Hs.466471 |
|---|---|
| Hs.599771 | |
| Mm.589 | |
| Mm.390025 | |
| Mm.471409 | |
| Rn.84435 |
| KEGG ID | hsa:2821 |
|---|---|
| mmu:14751 | |
| rno:292804 |
| EC Number | 5.3.1.9 |
|---|
| Swiss-Prot ID | G6PI_MOUSE |
|---|---|
| G6PI_HUMAN | |
| G6PI_RAT |
| Cell Localization | Cytoplasm |
|---|---|
| Secreted |
| IPI ID | IPI00228633 |
|---|---|
| IPI00027497 | |
| IPI00364311 | |
| IPI00556013 | |
| IPI00669556 |
| Homologene ID | 145 |
|---|---|
| 100529 |
| RGD ID | 2727 |
|---|
| MGI ID | 95797 |
|---|