| URN | urn:agi-llid:5106 |
|---|---|
| Connectivity | 308 |
| Name | Pck2 |
| Description | phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
| Notes | This gene encodes a member of the phosphoenolpyruvate carboxykinase (GTP) family. The protein is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of GTP. A cytosolic form encoded by a different gene has also been characterized and is the key enzyme of gluconeogenesis in the liver. The encoded protein may serve a similar function, although it is constitutively expressed and not modulated by hormones such as glucagon and insulin that regulate the cytosolic form. Alternatively spliced transcript variants have been described. |
| Pathway | gluconeogenesis pathway |
|---|
| GO Molecular Function | nucleotide binding |
|---|---|
| lyase activity | |
| purine nucleotide binding | |
| GTP binding | |
| metal ion binding | |
| manganese ion binding | |
| carboxy-lyase activity | |
| phosphoenolpyruvate carboxykinase activity | |
| phosphoenolpyruvate carboxykinase (GTP) activity |
| GO Cellular Component | soluble fraction |
|---|---|
| cytoplasm | |
| mitochondrion |
| GO Biological Process | gluconeogenesis |
|---|---|
| oxaloacetate metabolic process | |
| response to glucocorticoid stimulus |
| Ariadne Ontology | Tricarboxylic acid cycle |
|---|
| Group | Tricarboxylic acid cycle |
|---|---|
| gluconeogenesis | |
| oxaloacetate metabolic process | |
| response to glucocorticoid stimulus | |
| nucleotide binding | |
| lyase activity | |
| purine nucleotide binding | |
| GTP binding | |
| metal ion binding | |
| manganese ion binding | |
| carboxy-lyase activity | |
| phosphoenolpyruvate carboxykinase activity | |
| phosphoenolpyruvate carboxykinase (GTP) activity | |
| soluble fraction | |
| cytoplasm | |
| mitochondrion |
| MedScan ID | 5106 |
|---|
| Hugo ID | 8725 |
|---|
| Human chromosome position | 14q11.2 |
|---|---|
| 14q12 |
| LocusLink ID | 5106 |
|---|---|
| 74551 | |
| 361042 |
| Alias | PEPCK |
|---|---|
| PEPCK2 | |
| PEPCK-M | |
| phosphoenolpyruvate carboxykinase [GTP], mitochondrial | |
| PEP carboxykinase | |
| phosphopyruvate carboxylase | |
| phosphoenolpyruvate carboxylase | |
| 1810010O14Rik | |
| 9130022B02Rik | |
| phosphoenolpyruvate carboxykinase 2 (mitochondrial) | |
| 1810010O14 | |
| 9130022B02 | |
| gAF1/PCK2 | |
| mitochondrial phosphoenolpyruvate carboxykinase 2 | |
| mitochondrial phosphoenolpyruvate carboxykinase II | |
| mitochondrial Phosphoenolpyruvate carboxykinase precursor (GTP) | |
| OTTHUMP00000164700 | |
| PCK2 | |
| PEPCK-Ms | |
| Phosphoenolpyruvate carboxykinase | |
| phosphoenolpyruvate carboxykinase 2 | |
| Phosphoenolpyruvate carboxykinase, mitochondrial precursor (GTP) | |
| Phosphoenolpyruvate carboxylase 2 | |
| Phosphoenolpyruvate carboxylase II | |
| RATPEPCK | |
| RIKEN cDNA 9130022B02 gene | |
| RIKEN cDNA 1810010O14 gene | |
| PEPCK2s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 261650 |
|---|
| Mouse chromosome position | 14 21.0 cM |
|---|
| GO ID | 0005525 |
|---|---|
| 0016829 | |
| 0046872 | |
| 0004613 | |
| 0004611 | |
| 0017076 | |
| 0006094 | |
| 0006107 | |
| 0051384 | |
| 0005739 | |
| 0005625 | |
| 0016831 | |
| 0000166 | |
| 0005737 | |
| 0030145 | |
| 0003674 | |
| 0005575 | |
| 0016301 |
| Rat chromosome position | 15p13 |
|---|
| Swiss-Prot Accession | Q16822 |
|---|---|
| Q6IB91 | |
| Q8BH04 | |
| Q3TDE6 | |
| Q3UGF0 | |
| Q3UQD8 | |
| Q8R3X7 | |
| B2RYG2 | |
| Q8BMM9 | |
| Q91Z10 | |
| O43253 | |
| Q86U01 | |
| Q9BV62 |
| PIR ID | S69546 |
|---|
| Unigene ID | Hs.75812 |
|---|---|
| Mm.29856 | |
| Rn.35508 | |
| Mm.475905 |
| KEGG ID | hsa:5106 |
|---|---|
| mmu:74551 | |
| rno:361042 |
| EC Number | 4.1.1.32 |
|---|
| Swiss-Prot ID | PCKGM_MOUSE |
|---|---|
| PCKGM_HUMAN | |
| B2RYG2_RAT |
| Cell Localization | Mitochondrion |
|---|---|
| Mitochondria |
| IPI ID | IPI00223060 |
|---|---|
| IPI00294380 | |
| IPI00869844 | |
| IPI00384116 | |
| IPI00797038 |
| Homologene ID | 3356 |
|---|
| RGD ID | 1311112 |
|---|
| MGI ID | 1860456 |
|---|