| URN | urn:agi-llid:5315 |
|---|---|
| Total Entities | 0 |
| Connectivity | 448 |
| Name | PKM |
| Description | pyruvate kinase, muscle |
| Notes | The protein encoded by this gene is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. This protein has been shown to interact with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. |
| GO Molecular Function | catalytic activity |
|---|---|
| transferase activity | |
| kinase activity | |
| pyruvate kinase activity | |
| nucleotide binding | |
| ATP binding | |
| ADP binding | |
| metal ion binding | |
| magnesium ion binding | |
| potassium ion binding |
| GO Cellular Component | plasma membrane |
|---|---|
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| nucleus | |
| cilium | |
| extracellular vesicular exosome |
| GO Biological Process | metabolic process |
|---|---|
| small molecule metabolic process | |
| pyruvate biosynthetic process | |
| ATP biosynthetic process | |
| glycolytic process | |
| glucose metabolic process | |
| liver development | |
| organ regeneration | |
| skeletal muscle tissue regeneration | |
| programmed cell death | |
| response to organic substance | |
| response to nutrient | |
| response to insulin | |
| response to hypoxia | |
| response to gravity | |
| response to muscle inactivity | |
| phosphorylation | |
| carbohydrate metabolic process |
| Pathway | Glycolysis |
|---|---|
| Common Non-genomic Effects of Thyroid Hormones | |
| New Pathway | |
| glycolysis/gluconeogenesis pathway | |
| glycolysis pathway | |
| pyruvate metabolic pathway |
| Group | Glucose metabolism |
|---|---|
| Purine metabolism | |
| metabolic process | |
| small molecule metabolic process | |
| pyruvate biosynthetic process | |
| ATP biosynthetic process | |
| glycolytic process | |
| glucose metabolic process | |
| liver development | |
| organ regeneration | |
| skeletal muscle tissue regeneration | |
| programmed cell death | |
| response to organic substance | |
| response to nutrient | |
| response to insulin | |
| response to hypoxia | |
| response to gravity | |
| response to muscle inactivity | |
| catalytic activity | |
| transferase activity | |
| kinase activity | |
| pyruvate kinase activity | |
| phosphorylation | |
| carbohydrate metabolic process | |
| nucleotide binding | |
| ATP binding | |
| ADP binding | |
| metal ion binding | |
| magnesium ion binding | |
| potassium ion binding | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| nucleus | |
| cilium | |
| extracellular vesicular exosome | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 5315 |
|---|---|
| 18746 | |
| 25630 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| GO ID | 0005524 |
|---|---|
| 0000287 | |
| 0030955 | |
| 0004743 | |
| 0005975 | |
| 0006006 | |
| 0006096 | |
| 0012501 | |
| 0044281 | |
| 0005929 | |
| 0005737 | |
| 0005829 | |
| 0070062 | |
| 0005739 | |
| 0005634 | |
| 0005886 | |
| 0043531 | |
| 0003824 | |
| 0016301 | |
| 0046872 | |
| 0000166 | |
| 0016740 | |
| 0006754 | |
| 0001889 | |
| 0008152 | |
| 0031100 | |
| 0016310 | |
| 0042866 | |
| 0043403 | |
| 0009629 | |
| 0001666 | |
| 0032868 | |
| 0014870 | |
| 0007584 | |
| 0010033 | |
| 0005515 |
| Alias | PK3 |
|---|---|
| TCB | |
| OIP3 | |
| PKM2 | |
| CTHBP | |
| THBP1 | |
| HEL-S-30 | |
| pyruvate kinase PKM | |
| p58 | |
| OIP-3 | |
| tumor M2-PK | |
| PK, muscle type | |
| pyruvate kinase 2/3 | |
| OPA-interacting protein 3 | |
| pyruvate kinase isozymes M1/M2 | |
| pyruvate kinase muscle isozyme | |
| thyroid hormone-binding protein 1 | |
| epididymis secretory protein Li 30 | |
| cytosolic thyroid hormone-binding protein | |
| thyroid hormone-binding protein, cytosolic | |
| Pk-2 | |
| Pk-3 | |
| AA414905 | |
| AL024370 | |
| AL024424 | |
| pyruvate kinase, muscle | |
| pyruvate kinase 3 | |
| PKM12 | |
| Pykm | |
| THBP I | |
| Pyruvate kinase, M2 isozyme | |
| Pyruvate kinase III | |
| pyruvate kinase M2 | |
| thyroid hormone binding protein | |
| thyroid hormone-binding protein | |
| Thyroid hormone-binding protein, cytosolic (p58) | |
| muscle pyruvate kinase | |
| Chain A, Recombinant Rabbit Muscle Pyruvate Kinase | |
| cytosolic thyroid hormone binding protein | |
| MGC3932 | |
| anti-neoplastic urinary protein | |
| muscle PK | |
| PK, muscle | |
| OPA-interacting protein III | |
| 1110021N19 | |
| PKM | |
| 1110021N19Rik | |
| Pyruvate kinase-3 | |
| RIKEN cDNA 1110021N19 gene | |
| cytosolic Thyroid hormone-binding protein (p58) |
| Mouse chromosome position | 9 32.03 cM |
|---|---|
| 9 52.0 cM |
| OMIM ID | 179050 |
|---|
| Rat chromosome position | 8q24 |
|---|
| Hugo ID | 9021 |
|---|
| Human chromosome position | 15q22 |
|---|
| Swiss-Prot Accession | P14618 |
|---|---|
| B4DNK4 | |
| P52480 | |
| P11980 | |
| Q3TBV8 | |
| Q3TBW5 | |
| Q3TC59 | |
| Q3U1X3 | |
| Q3U5P6 | |
| Q4VC20 | |
| Q64484 | |
| Q91YI8 | |
| Q9CWB1 | |
| P11981 | |
| A6NFK3 | |
| B2R5N8 | |
| B3KRY0 | |
| B4DFX8 | |
| B4DUU6 | |
| P14786 | |
| Q53GK4 | |
| Q96E76 | |
| Q9BWB5 | |
| Q9UCV6 | |
| Q9UPF2 |
| PIR ID | S55921 |
|---|---|
| A26186 | |
| B26186 | |
| S30038 | |
| S64635 |
| Unigene ID | Hs.534770 |
|---|---|
| Mm.326167 | |
| Mm.488724 | |
| Rn.1556 |
| KEGG ID | hsa:5315 |
|---|---|
| mmu:18746 | |
| rno:25630 |
| Swiss-Prot ID | KPYM_MOUSE |
|---|---|
| KPYM_RAT | |
| KPYM_HUMAN |
| EC Number | 2.7.1.40 |
|---|
| Ensembl ID | ENSG00000067225 |
|---|---|
| ENSP00000403365 | |
| ENST00000449901 | |
| ENSP00000334983 | |
| ENST00000335181 | |
| ENSP00000320171 | |
| ENST00000319622 | |
| ENSP00000373745 | |
| ENST00000389093 | |
| ENSMUSG00000032294 | |
| ENSMUSP00000128770 | |
| ENSMUST00000163694 | |
| ENSMUSP00000034834 | |
| ENSMUST00000034834 | |
| ENSRNOG00000011329 | |
| ENSRNOP00000015331 | |
| ENSRNOT00000015332 |
| Homologene ID | 37650 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 97591 |
|---|
| RGD ID | 3337 |
|---|
| MedScan ID | 5315 |
|---|