Protein GPI

URN	urn:agi-llid:2821
Total Entities	0
Connectivity	438
Name	GPI
Description	glucose phosphate isomerase
Notes	This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.

GO Molecular Function	isomerase activity
	intramolecular transferase activity
	glucose-6-phosphate isomerase activity
	growth factor activity
	cytokine activity
	monosaccharide binding

GO Biological Process	erythrocyte homeostasis
	humoral immune response
	small molecule metabolic process
	gluconeogenesis
	methylglyoxal biosynthetic process
	aldehyde catabolic process
	glycolytic process
	glucose metabolic process
	hemostasis
	learning or memory
	angiogenesis
	in utero embryonic development
	mesoderm formation
	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
	negative regulation of neuron apoptotic process
	glucose 6-phosphate metabolic process
	carbohydrate metabolic process
	glucose homeostasis

Pathway	Proliferative Diabetic Retinopathy
	Glycolysis
	Role of Hexosamine Pathway in Diabetic Microangiopathy
	Peripheral Tissue Microangiopathy in Insulin Resistance
	New Pathway
	glycolysis/gluconeogenesis pathway
	gluconeogenesis pathway
	glycolysis pathway

Group	Glucose metabolism
	Pentose-phosphate shunt
	erythrocyte homeostasis
	humoral immune response
	small molecule metabolic process
	gluconeogenesis
	methylglyoxal biosynthetic process
	aldehyde catabolic process
	glycolytic process
	glucose metabolic process
	hemostasis
	learning or memory
	angiogenesis
	in utero embryonic development
	mesoderm formation
	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
	negative regulation of neuron apoptotic process
	isomerase activity
	intramolecular transferase activity
	glucose-6-phosphate isomerase activity
	glucose 6-phosphate metabolic process
	carbohydrate metabolic process
	glucose homeostasis
	growth factor activity
	cytokine activity
	monosaccharide binding
	extracellular region
	ciliary membrane
	nucleolus
	plasma membrane
	cytoplasm
	cytosol
	nucleus
	neuron projection
	extracellular space
	Secreted proteins
	Biofluids assayable substances

Cell Localization	Cytoplasm
	Secreted

Alias	AMF
	NLK
	PGI
	PHI
	GNPI
	SA36
	SA-36
	glucose-6-phosphate isomerase
	neuroleukin
	oxoisomerase
	sperm antigen 36
	sperm antigen-36
	phosphohexomutase
	phosphosaccharomutase
	phosphohexose isomerase
	phosphoglucose isomerase
	autocrine motility factor
	hexosephosphate isomerase
	glucose phosphate isomerase
	hexose monophosphate isomerase
	MF
	NK
	Gpi
	Org
	Gpi-1
	Gpi1s
	Gpi-1r
	Gpi-1s
	Gpi-1t
	Gpi1-r
	Gpi1-s
	Gpi1-t
	NK/GPI
	RP23-349I9.4
	maturation factor
	glucose phosphate isomerase 1 complex
	glucose phosphate isomerase 1, temporal
	structural glucose phosphate isomerase 1
	glucose phosphate isomerase 1, regulatory
	glucose phosphate isomerase 1, structural
	Gpi1
	MGC113776
	OTTMUSP00000008735
	PGI/NLK/AMF
	structural glucose phosphate isomerase I
	LOC676974
	DKFZp686C13233
	Gpi-1ss
	glucose phosphate isomerase 1
	Gpi-1ts
	glucose phosphate isomerase I
	Gpi-1rs
	glucose-6-phosphate isomerase (EC 5.3.1.9)
	glucose phosphohexomutase

Mouse chromosome position	7 19.46 cM
	7 11.0 cM

OMIM ID	172400
	613470

Rat chromosome position	1q21

Hugo ID	4458

Human chromosome position	19q13.1

PIR ID	A35333
	A24439

EC Number	5.3.1.9

Homologene ID	145
	100529

MGI ID	95797

RGD ID	2727

MedScan ID	2821