Ariadne Genomics Inc. phosphoenolpyruvate gluconeogenesis pathway pyruvate metabolic pathway aldolases Pfkfb members (kinase) Pfkfb members (phosphatase) phosphofructokinases enolases hexokinases ATP ---| phosphofructokinases F2,6P --+> phosphofructokinases AMP --+> phosphofructokinases Tpi1 glyceraldehyde-3-phosphate <--> dihydroxyacetone-phosphate Gapdh Pgk1 Pgam2 Pkm2 Gpi glucose Pfkfb members (phosphatase) ---| F2,6P phosphoenolpyruvate ---> pyruvate glyceraldehyde-3-phosphate <--> 1,3-biphosphoglycerate fructose-1,6-diphosphate <--> glyceraldehyde-3-phosphate 3-phosphoglycerate <--> 2-phosphoglycerate pyruvate ---> pyruvate metabolic pathway pyruvate fructose-6-phosphate ---> fructose-1,6-diphosphate Pfkfb members (kinase) --+> F2,6P ATP ---- phosphofructokinases pyruvate ---> gluconeogenesis pathway glucose-6-phosphate <--> fructose-6-phosphate fructose-1,6-diphosphate <--> dihydroxyacetone-phosphate AMP F2,6P 3-phosphoglycerate <--> 1,3-biphosphoglycerate 1,3-biphosphoglycerate 3-phosphoglycerate 2-phosphoglycerate glucose-6-phosphate fructose-6-phosphate ATP fructose-1,6-diphosphate dihydroxyacetone-phosphate glyceraldehyde-3-phosphate Pklr 2-phosphoglycerate <--> phosphoenolpyruvate glucose ---> glucose-6-phosphate