| URN | urn:agi-llid:8773 |
|---|---|
| Total Entities | 0 |
| Connectivity | 282 |
| Name | Snap23 |
| Description | synaptosomal-associated protein, 23kDa |
| Notes | Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. |
| GO Molecular Function | SNAP receptor activity |
|---|---|
| syntaxin binding |
| GO Cellular Component | membrane |
|---|---|
| synapse | |
| cell junction | |
| cell | |
| SNARE complex | |
| cytoplasmic vesicle membrane | |
| nucleolus | |
| plasma membrane | |
| Golgi apparatus | |
| cytoplasmic vesicle | |
| azurophil granule | |
| specific granule | |
| nucleus | |
| neuron projection |
| GO Biological Process | vesicle targeting |
|---|---|
| exocytosis | |
| regulation of exocytosis | |
| post-Golgi vesicle-mediated transport | |
| transport | |
| vesicle-mediated transport | |
| protein transport | |
| protein complex assembly | |
| membrane fusion |
| Pathway | P2RXs -> synaptic transmission |
|---|---|
| insulin responsive facilitative sugar transporter mediated glucose transport pathway | |
| altered insulin responsive facilitative sugar transporter mediated glucose transport pathway | |
| vasopressin signaling pathway via receptor type 2 | |
| vasopressin signaling pathway - first | |
| insulin responsive facilitative sugar transporter mediated glucose transport pathway |
| Group | Vesicular secretory pathway |
|---|---|
| Transcytosis | |
| vesicle targeting | |
| exocytosis | |
| regulation of exocytosis | |
| post-Golgi vesicle-mediated transport | |
| transport | |
| vesicle-mediated transport | |
| protein transport | |
| protein complex assembly | |
| membrane fusion | |
| SNAP receptor activity | |
| syntaxin binding | |
| membrane | |
| synapse | |
| cell junction | |
| cell | |
| SNARE complex | |
| cytoplasmic vesicle membrane | |
| nucleolus | |
| plasma membrane | |
| Golgi apparatus | |
| cytoplasmic vesicle | |
| azurophil granule | |
| specific granule | |
| nucleus | |
| neuron projection | |
| Secreted proteins |
| LocusLink ID | 8773 |
|---|---|
| 20619 | |
| 64630 |
| Cell Localization | Golgi |
|---|---|
| Plasma membrane | |
| Cell membrane | |
| Cell junction | |
| Synapse | |
| Synaptosome | |
| Cytoplasmic vesicle membrane |
| GO ID | 0006887 |
|---|---|
| 0061025 | |
| 0006892 | |
| 0015031 | |
| 0006903 | |
| 0005794 | |
| 0042582 | |
| 0030054 | |
| 0043005 | |
| 0005730 | |
| 0005634 | |
| 0005886 | |
| 0042581 | |
| 0045202 | |
| 0019905 | |
| 0006461 | |
| 0017157 | |
| 0006810 | |
| 0016192 | |
| 0031201 | |
| 0005623 | |
| 0031410 | |
| 0016020 | |
| 0005484 | |
| 0030659 | |
| 0005515 | |
| 0006944 | |
| 0019717 | |
| 0008565 | |
| 0006886 | |
| 0007033 | |
| 0005792 | |
| 0030133 |
| Alias | SNAP-23 |
|---|---|
| SNAP23A | |
| SNAP23B | |
| HsT17016 | |
| synaptosomal-associated protein 23 | |
| vesicle-membrane fusion protein SNAP-23 | |
| Sndt | |
| 23kDa | |
| Syndet | |
| AA408749 | |
| RP23-158L6.2 | |
| synaptosomal-associated protein, 23kD | |
| synaptosomal-associated protein 23 kD | |
| synaptosomal-associated protein, 23 kD | |
| synaptosomal-associated protein, 23kDa | |
| synaptosomal-associated protein 23 isoform SNAP23B | |
| synaptosomal-associated protein 23 isoform SNAP23A | |
| OTTHUMP00000161263 | |
| 23 kDa synaptosomal-associated protein | |
| OTTMUSP00000016633 | |
| OTTMUSP00000016634 | |
| OTTMUSP00000016635 | |
| OTTMUSP00000041372 | |
| SNAP23 | |
| SNAP23s | |
| Vesicle-membrane fusion protein SNAP-23 |
| Mouse chromosome position | 2 60.37 cM |
|---|---|
| 2 61.8 cM |
| OMIM ID | 602534 |
|---|
| Rat chromosome position | 3q25 |
|---|---|
| 3 |
| Hugo ID | 11131 |
|---|
| Human chromosome position | 15q14 |
|---|---|
| 15q15.1 |
| Swiss-Prot Accession | A8K287 |
|---|---|
| O00161 | |
| O09044 | |
| Q9D3L3 | |
| A2AKH4 | |
| O70377 | |
| A0JPL8 | |
| O00162 | |
| Q13602 | |
| Q6IAE3 | |
| O35620 |
| PIR ID | JC5296 |
|---|---|
| JC5297 | |
| JC5512 |
| Unigene ID | Hs.511149 |
|---|---|
| Mm.245715 | |
| Rn.14789 |
| KEGG ID | hsa:8773 |
|---|---|
| mmu:20619 | |
| rno:64630 |
| Swiss-Prot ID | SNP23_RAT |
|---|---|
| SNP23_HUMAN | |
| SNP23_MOUSE |
| Ensembl ID | ENSG00000092531 |
|---|---|
| ENSP00000249647 | |
| ENST00000249647 | |
| ENSP00000207062 | |
| ENST00000349777 | |
| ENSMUSG00000027287 | |
| ENSMUSP00000106339 | |
| ENSMUST00000110711 |
| Homologene ID | 37857 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 109356 |
|---|
| RGD ID | 620221 |
|---|
| MedScan ID | 8773 |
|---|