Protein Slc2a4

URN	urn:agi-llid:6517
Total Entities	0
Connectivity	1872
Name	Slc2a4
Description	solute carrier family 2 (facilitated glucose transporter), member 4
Notes	This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM).

GO Molecular Function	transmembrane transporter activity
	insulin-responsive hydrogen:glucose symporter activity
	glucose transmembrane transporter activity
	D-glucose transmembrane transporter activity
	substrate-specific transmembrane transporter activity
	transporter activity

GO Cellular Component	membrane
	integral component of membrane
	coated pit
	T-tubule
	external side of plasma membrane
	integral component of plasma membrane
	vesicle membrane
	cytoplasmic vesicle membrane
	trans-Golgi network transport vesicle
	endomembrane system
	cell surface
	plasma membrane
	cytoplasm
	perinuclear region of cytoplasm
	endosome
	multivesicular body
	insulin-responsive compartment
	clathrin-coated vesicle
	intracellular membrane-bounded organelle
	sarcolemma
	extracellular vesicular exosome
	vesicle

GO Biological Process	small molecule metabolic process
	brown fat cell differentiation
	transmembrane transport
	ion transmembrane transport
	hexose transmembrane transport
	carbohydrate transport
	proton transport
	hexose transport
	glucose transport
	glucose import
	response to ethanol
	cellular response to insulin stimulus
	cellular response to hypoxia
	cellular response to osmotic stress
	amylopectin biosynthetic process
	carbohydrate metabolic process
	transport
	glucose homeostasis

Pathway	Androgen Receptor to SGK1 Signaling in Prostate Cancer
	Myostatin-IGF1 Crosstalk in Skeletal Muscles
	IL6 in Insulin Resistance
	IGF1 in Muscle Hypertrophy
	Insulin Influence on Glycogenesis
	Obesity Induced Insulin Resistance in Myocytes
	Insulin Resistance in Hepatocytes
	Insulin Influence on Lipogenesis
	Proteins Involved in Pathogenesis of Insulin Resistance
	Role of Adiponectin in Insulin Resistance Prevention
	Proteins Involved in Pathogenesis of Diabetes Mellitus Type 2
	Proteins Involved in Pathogenesis of Polycystic Ovary Syndrome
	Proteins Involved in Pathogenesis of Myocardial Ischemia
	Dexamethasone-Induced Diabetes
	Ritonavir-Induced Diabetes
	TNF/TP53/ATF Expression Targets
	PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets
	PRL-GHR/STAT Expression Targets
	CNTF Expression Targets
	CCL2 Expression Targets
	IGF2/MEF/MYOD Expression Targets
	AVP/Gq -> MEF/MYOD/NFATC/MYOG Expression Targets
	AVP/Gs -> MEF/MYOD/NFATC/MYOG Expression Targets
	AGT/TP53 Expression Targets
	FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
	IGF1/MEF/MYOD/MYOG Expression Targets
	Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets
	Insulin/MEF/MYOD Expression Targets
	TLR4/AP-1/EGR1/HIF1A Expression Targets
	insulin responsive facilitative sugar transporter mediated glucose transport pathway
	altered insulin responsive facilitative sugar transporter mediated glucose transport pathway
	insulin responsive facilitative sugar transporter mediated glucose transport pathway

Group	Glucose import
	small molecule metabolic process
	brown fat cell differentiation
	transmembrane transport
	transmembrane transporter activity
	ion transmembrane transport
	insulin-responsive hydrogen:glucose symporter activity
	hexose transmembrane transport
	glucose transmembrane transporter activity
	D-glucose transmembrane transporter activity
	substrate-specific transmembrane transporter activity
	carbohydrate transport
	proton transport
	hexose transport
	glucose transport
	glucose import
	response to ethanol
	cellular response to insulin stimulus
	cellular response to hypoxia
	cellular response to osmotic stress
	amylopectin biosynthetic process
	carbohydrate metabolic process
	transport
	transporter activity
	glucose homeostasis
	membrane
	integral component of membrane
	coated pit
	T-tubule
	external side of plasma membrane
	integral component of plasma membrane
	vesicle membrane
	cytoplasmic vesicle membrane
	trans-Golgi network transport vesicle
	endomembrane system
	cell surface
	plasma membrane
	cytoplasm
	perinuclear region of cytoplasm
	endosome
	multivesicular body
	insulin-responsive compartment
	clathrin-coated vesicle
	intracellular membrane-bounded organelle
	sarcolemma
	extracellular vesicular exosome
	vesicle
	Secreted proteins
	Biofluids assayable substances

Alias	GLUT4
	solute carrier family 2, facilitated glucose transporter member 4
	GLUT-4
	insulin-responsive glucose transporter type 4
	glucose transporter type 4, insulin-responsive
	GT2
	solute carrier family 2 member 4
	solute carrier family 2 , member 4
	Glucose transporter 4 insuline-responsive
	Glucose transporter 4, insuline-responsive
	glucose transporter GLUT4
	solute carrier family 2 , member IV
	solute carrier family 2 (facilitated glucose transporter), member IV
	solute carrier family 2 (facilitated glucose transporter), member 4
	SLC2A4
	OTTMUSP00000006275
	glucose transporter 4
	facilitated glucose transporter IV
	facilitated glucose transporter 4
	MGC93607

Mouse chromosome position	11 42.93 cM
	11 40.0 cM

OMIM ID	138190
	125853

Rat chromosome position	10q24

Hugo ID	11009

Human chromosome position	17p13

Homologene ID	74381

MGI ID	95758

RGD ID	2711

MedScan ID	6517