Protein Rhoq

URN	urn:agi-llid:23433
Total Entities	0
Connectivity	141
Name	Rhoq
Description	ras homolog family member Q
Notes	This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]

GO Biological Process	GTP catabolic process
	regulation of cell shape
	actin cytoskeleton organization
	regulation of actin cytoskeleton organization
	cortical actin cytoskeleton organization
	small GTPase mediated signal transduction
	regulation of small GTPase mediated signal transduction
	insulin receptor signaling pathway
	positive regulation of filopodium assembly
	negative regulation of establishment of protein localization to plasma membrane
	positive regulation of glucose import
	negative regulation of glucose import
	cellular response to insulin stimulus
	positive regulation of transcription from RNA polymerase II promoter

Pathway	Class II Mutations Cause CFTR Misfolding and Degradation in Cystic Fibrosis
	insulin responsive facilitative sugar transporter mediated glucose transport pathway

Group	GTP catabolic process
	GTPase activity
	regulation of cell shape
	actin cytoskeleton organization
	regulation of actin cytoskeleton organization
	cortical actin cytoskeleton organization
	small GTPase mediated signal transduction
	regulation of small GTPase mediated signal transduction
	insulin receptor signaling pathway
	positive regulation of filopodium assembly
	negative regulation of establishment of protein localization to plasma membrane
	positive regulation of glucose import
	negative regulation of glucose import
	cellular response to insulin stimulus
	positive regulation of transcription from RNA polymerase II promoter
	profilin binding
	GBD domain binding
	nucleotide binding
	GTP binding
	membrane
	membrane raft
	actin filament
	intracellular
	plasma membrane
	cytoplasm
	cytosol
	Secreted proteins

Cell Localization	Cytoplasm
	Cell membrane

Alias	ARHQ
	TC10
	TC10A
	RASL7A
	HEL-S-42
	rho-related GTP-binding protein RhoQ
	ras-like protein TC10
	RAS-like, family 7, member A
	ras homolog gene family, member Q
	ras-like protein family member 7A
	epididymis secretory protein Li 42
	small GTPase Tc10
	ras-related GTP-binding protein TC10
	TC-10
	RHOQ
	OTTMUSP00000029031
	OTTMUSP00000029030
	LOC150843
	AHRQ

Mouse chromosome position	17 56.9 cM

OMIM ID	605857

Rat chromosome position	6q12

Hugo ID	17736

Human chromosome position	2p21

PIR ID	D34788

Homologene ID	22704

MGI ID	1931553

RGD ID	621626

MedScan ID	23433