Protein Limk1

URN	urn:agi-llid:3984
Total Entities	0
Connectivity	500
Name	Limk1
Description	LIM domain kinase 1
Notes	There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]

GO Molecular Function	transferase activity
	transferase activity, transferring phosphorus-containing groups
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	heat shock protein binding
	protein heterodimerization activity
	nucleotide binding
	ATP binding
	metal ion binding
	zinc ion binding

GO Cellular Component	nucleolus
	cytoplasm
	Golgi apparatus
	cytosol
	perinuclear region of cytoplasm
	nucleus
	axonal growth cone
	neuron projection
	focal adhesion

GO Biological Process	Fc-gamma receptor signaling pathway involved in phagocytosis
	innate immune response
	nervous system development
	positive regulation of axon extension
	axon guidance
	actin cytoskeleton organization
	positive regulation of actin filament bundle assembly
	positive regulation of stress fiber assembly
	signal transduction
	Rho protein signal transduction
	negative regulation of ubiquitin-protein ligase activity
	protein phosphorylation
	phosphorylation

Pathway	Actin Cytoskeleton Assembly
	Proteins Involved in Pathogenesis of Alzheimer's Disease
	Endothelial Cell Dysfunction in Pulmonary Arterial Hypertension
	Smooth Muscle Cell Dysfunction in Pulmonary Arterial Hypertension
	Glioma Invasion Signaling
	Impairment of EDN, NRG, NRTN, and GDNF/RET Signaling in Hirschsprung Disease
	Synovial Fibroblast Proliferation in Rheumatoid Arthritis
	EphrinR -> actin signaling
	insulin responsive facilitative sugar transporter mediated glucose transport pathway

Group	LIMK
	Fc-gamma receptor signaling pathway involved in phagocytosis
	innate immune response
	nervous system development
	positive regulation of axon extension
	axon guidance
	actin cytoskeleton organization
	positive regulation of actin filament bundle assembly
	positive regulation of stress fiber assembly
	signal transduction
	Rho protein signal transduction
	negative regulation of ubiquitin-protein ligase activity
	transferase activity
	transferase activity, transferring phosphorus-containing groups
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	protein phosphorylation
	phosphorylation
	heat shock protein binding
	protein heterodimerization activity
	nucleotide binding
	ATP binding
	metal ion binding
	zinc ion binding
	nucleolus
	cytoplasm
	Golgi apparatus
	cytosol
	perinuclear region of cytoplasm
	nucleus
	axonal growth cone
	neuron projection
	focal adhesion
	Secreted proteins

Cell Localization	Cytoplasm
	Nucleus

Alias	LIMK
	LIMK-1
	LIM domain kinase 1
	LIM motif-containing protein kinase
	KIZ-1
	LIM motif-containing protein kinase 1
	LIM-domain containing protein kinase 1
	LIM-domain containing, protein kinase 1
	OTTMUSP00000032204
	LIMK1
	LOC269714
	LOC547389
	mLimk1
	OTTHUMP00000025066
	kinase LIMK1
	OTTMUSP00000032203
	LIMK1 kinase
	LOC547384
	LIMK I
	OTTHUMP00000211913
	LIM kinase 1
	mLimk I
	LIM domain kinase I
	dLIMK
	LIM kinase I
	LIM motif-containing protein kinase I
	LIM-domain containing, protein kinase
	LIM-domain containing, protein kinase I

Mouse chromosome position	5 74.73 cM

OMIM ID	601329

Rat chromosome position	12q12

Hugo ID	6613

Human chromosome position	7q11.23

PIR ID	I48737
	JP0078

Swiss-Prot ID	LIMK1_MOUSE
	LIMK1_HUMAN

EC Number	2.7.11.1

Homologene ID	1738

MGI ID	104572

RGD ID	62055

MedScan ID	3984