| URN | urn:agi-llid:8773 |
|---|---|
| Connectivity | 106 |
| Name | Snap23 |
| Description | synaptosomal-associated protein, 23kDa |
| Notes | Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. |
| Pathway | insulin responsive facilitative sugar transporter mediated glucose transport pathway |
|---|---|
| altered insulin responsive facilitative sugar transporter mediated glucose transport pathway | |
| vasopressin signaling pathway via receptor type 2 | |
| vasopressin signaling pathway - first |
| GO Molecular Function | syntaxin binding |
|---|
| GO Cellular Component | synapse |
|---|---|
| membrane | |
| plasma membrane enriched fraction | |
| plasma membrane | |
| SNARE complex | |
| cytoplasmic vesicle | |
| cytoplasmic vesicle membrane | |
| azurophil granule | |
| specific granule | |
| nucleus | |
| synaptosome | |
| microsome | |
| cell junction |
| GO Biological Process | vesicle targeting |
|---|---|
| cellular membrane organization | |
| vesicle-mediated transport | |
| transport | |
| exocytosis | |
| cellular membrane fusion | |
| regulation of exocytosis | |
| post-Golgi vesicle-mediated transport | |
| protein complex assembly | |
| protein transport |
| Ariadne Ontology | Vesicular secretory pathway |
|---|---|
| Transcytosis |
| Group | Vesicular secretory pathway |
|---|---|
| Transcytosis | |
| synapse | |
| vesicle targeting | |
| cellular membrane organization | |
| vesicle-mediated transport | |
| transport | |
| exocytosis | |
| cellular membrane fusion | |
| regulation of exocytosis | |
| post-Golgi vesicle-mediated transport | |
| protein complex assembly | |
| protein transport | |
| syntaxin binding | |
| membrane | |
| plasma membrane enriched fraction | |
| plasma membrane | |
| SNARE complex | |
| cytoplasmic vesicle | |
| cytoplasmic vesicle membrane | |
| azurophil granule | |
| specific granule | |
| nucleus | |
| synaptosome | |
| microsome | |
| cell junction |
| MedScan ID | 8773 |
|---|
| Hugo ID | 11131 |
|---|
| Human chromosome position | 15q15.1-q15.2 |
|---|---|
| 15q15.1 |
| LocusLink ID | 8773 |
|---|---|
| 20619 | |
| 64630 |
| Alias | SNAP23A |
|---|---|
| SNAP23B | |
| HsT17016 | |
| synaptosomal-associated protein 23 | |
| SNAP-23 | |
| OTTHUMP00000161263 | |
| vesicle-membrane fusion protein SNAP-23 | |
| Sndt | |
| 23kDa | |
| Syndet | |
| AA408749 | |
| RP23-158L6.2 | |
| OTTMUSP00000016633 | |
| OTTMUSP00000016634 | |
| OTTMUSP00000016635 | |
| OTTMUSP00000041372 | |
| synaptosomal-associated protein, 23kD | |
| synaptosomal-associated protein 23 kD | |
| synaptosomal-associated protein, 23 kD | |
| 23 kDa synaptosomal-associated protein | |
| SNAP23 | |
| synaptosomal-associated protein 23 isoform SNAP23A | |
| synaptosomal-associated protein 23 isoform SNAP23B | |
| synaptosomal-associated protein, 23kDa | |
| Vesicle-membrane fusion protein SNAP-23 | |
| SNAP23s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602534 |
|---|
| Mouse chromosome position | 2 61.8 cM |
|---|
| GO ID | 0006944 |
|---|---|
| 0016044 | |
| 0006892 | |
| 0015031 | |
| 0006903 | |
| 0042582 | |
| 0030054 | |
| 0005886 | |
| 0001950 | |
| 0042581 | |
| 0045202 | |
| 0019717 | |
| 0019905 | |
| 0006887 | |
| 0006461 | |
| 0017157 | |
| 0006810 | |
| 0016192 | |
| 0031201 | |
| 0031410 | |
| 0016020 | |
| 0005792 | |
| 0030659 | |
| 0005634 | |
| 0005515 | |
| 0005737 | |
| 0005484 | |
| 0008565 | |
| 0006886 | |
| 0007033 | |
| 0030133 |
| Rat chromosome position | 3q25 |
|---|---|
| 3 |
| Swiss-Prot Accession | A8K287 |
|---|---|
| O00161 | |
| A2AKH4 | |
| O09044 | |
| Q9D3L3 | |
| O70377 | |
| O00162 | |
| Q13602 | |
| Q6IAE3 | |
| A0JPL8 | |
| O35620 |
| PIR ID | JC5296 |
|---|---|
| JC5297 | |
| JC5512 |
| Unigene ID | Hs.724586 |
|---|---|
| Mm.245715 | |
| Rn.14789 | |
| Hs.511149 |
| KEGG ID | hsa:8773 |
|---|---|
| mmu:20619 | |
| rno:64630 |
| Swiss-Prot ID | SNP23_HUMAN |
|---|---|
| SNP23_RAT | |
| SNP23_MOUSE | |
| A2AKH4_MOUSE | |
| A8K287_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Cell junction | |
| synapse | |
| synaptosome | |
| Cytoplasmic vesicle membrane | |
| Golgi | |
| Plasma membrane |
| IPI ID | IPI00010438 |
|---|---|
| IPI00216231 | |
| IPI00197605 | |
| IPI00622270 | |
| IPI00796942 | |
| IPI00794966 | |
| IPI00795513 | |
| IPI00794436 | |
| IPI00795000 | |
| IPI00793639 | |
| IPI00113798 | |
| IPI00894927 | |
| IPI00894609 | |
| IPI00895074 |
| Homologene ID | 37857 |
|---|
| RGD ID | 620221 |
|---|
| MGI ID | 109356 |
|---|