| URN | urn:agi-llid:6517 |
|---|---|
| Connectivity | 645 |
| Name | Slc2a4 |
| Description | solute carrier family 2 (facilitated glucose transporter), member 4 |
| Notes | This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). |
| Pathway | insulin responsive facilitative sugar transporter mediated glucose transport pathway |
|---|---|
| altered insulin responsive facilitative sugar transporter mediated glucose transport pathway |
| GO Molecular Function | transporter activity |
|---|---|
| substrate-specific transmembrane transporter activity | |
| insulin-responsive hydrogen:glucose symporter activity | |
| glucose transmembrane transporter activity | |
| D-glucose transmembrane transporter activity |
| GO Cellular Component | membrane |
|---|---|
| vesicle | |
| soluble fraction | |
| plasma membrane | |
| cytoplasm | |
| coated pit | |
| endosome | |
| perinuclear region of cytoplasm | |
| cytoplasmic vesicle membrane | |
| trans-Golgi network transport vesicle | |
| multivesicular body | |
| clathrin-coated vesicle | |
| insulin-responsive compartment | |
| membrane fraction | |
| integral to membrane of membrane fraction | |
| microsome | |
| external side of plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| sarcolemma | |
| vesicle membrane | |
| extracellular vesicular exosome |
| GO Biological Process | transmembrane transport |
|---|---|
| transport | |
| brown fat cell differentiation | |
| response to ethanol | |
| carbohydrate metabolic process | |
| carbohydrate transport | |
| glucose transport | |
| glucose import | |
| glucose homeostasis |
| Ariadne Ontology | Glucose import |
|---|
| Group | Glucose import |
|---|---|
| transporter activity | |
| transmembrane transport | |
| transport | |
| brown fat cell differentiation | |
| response to ethanol | |
| carbohydrate metabolic process | |
| carbohydrate transport | |
| glucose transport | |
| glucose import | |
| glucose homeostasis | |
| substrate-specific transmembrane transporter activity | |
| insulin-responsive hydrogen:glucose symporter activity | |
| glucose transmembrane transporter activity | |
| D-glucose transmembrane transporter activity | |
| membrane | |
| vesicle | |
| soluble fraction | |
| plasma membrane | |
| cytoplasm | |
| coated pit | |
| endosome | |
| perinuclear region of cytoplasm | |
| cytoplasmic vesicle membrane | |
| trans-Golgi network transport vesicle | |
| multivesicular body | |
| clathrin-coated vesicle | |
| insulin-responsive compartment | |
| membrane fraction | |
| integral to membrane of membrane fraction | |
| microsome | |
| external side of plasma membrane | |
| integral to membrane | |
| integral to plasma membrane | |
| sarcolemma | |
| vesicle membrane | |
| extracellular vesicular exosome |
| MedScan ID | 6517 |
|---|
| Hugo ID | 11009 |
|---|
| Human chromosome position | 17p13 |
|---|
| LocusLink ID | 6517 |
|---|---|
| 20528 | |
| 25139 |
| Alias | GLUT4 |
|---|---|
| solute carrier family 2, facilitated glucose transporter member 4 | |
| GLUT-4 | |
| insulin-responsive glucose transporter type 4 | |
| glucose transporter type 4, insulin-responsive | |
| GT2 | |
| OTTMUSP00000006275 | |
| MGC93607 | |
| solute carrier family 2 member 4 | |
| solute carrier family 2 , member 4 | |
| Glucose transporter 4 insuline-responsive | |
| Glucose transporter 4, insuline-responsive | |
| facilitated glucose transporter 4 | |
| facilitated glucose transporter IV | |
| glucose transporter 4 | |
| SLC2A4 | |
| solute carrier family 2 (facilitated glucose transporter), member 4 | |
| solute carrier family 2 (facilitated glucose transporter), member IV | |
| solute carrier family 2 , member IV |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 138190 |
|---|---|
| 125853 |
| Mouse chromosome position | 11 40.0 cM |
|---|
| GO ID | 0055056 |
|---|---|
| 0005355 | |
| 0022891 | |
| 0005215 | |
| 0050873 | |
| 0005975 | |
| 0008643 | |
| 0042593 | |
| 0046323 | |
| 0015758 | |
| 0045471 | |
| 0055085 | |
| 0030136 | |
| 0005905 | |
| 0005737 | |
| 0005768 | |
| 0009897 | |
| 0032593 | |
| 0000299 | |
| 0005887 | |
| 0005624 | |
| 0005792 | |
| 0005771 | |
| 0048471 | |
| 0042383 | |
| 0005625 | |
| 0030140 | |
| 0031982 | |
| 0012506 | |
| 0005360 | |
| 0006810 | |
| 0030659 | |
| 0070062 | |
| 0016021 | |
| 0016020 | |
| 0005886 | |
| 0005515 | |
| 0005351 | |
| 0012505 |
| Rat chromosome position | 10q24 |
|---|
| Swiss-Prot Accession | P14672 |
|---|---|
| Q05BQ3 | |
| P14142 | |
| Q3TPK6 | |
| P19357 | |
| Q14CX2 | |
| P97900 | |
| Q9JJN9 |
| PIR ID | A49158 |
|---|---|
| A32101 | |
| B30310 |
| Unigene ID | Hs.380691 |
|---|---|
| Mm.10661 | |
| Rn.1314 |
| KEGG ID | hsa:6517 |
|---|---|
| mmu:20528 | |
| rno:25139 |
| Swiss-Prot ID | GTR4_HUMAN |
|---|---|
| GTR4_RAT | |
| GTR4_MOUSE | |
| Q05BQ3_HUMAN | |
| Q3TPK6_MOUSE |
| Cell Localization | Endomembrane system |
|---|---|
| Cytoplasm | |
| perinuclear region | |
| Plasma membrane |
| IPI ID | IPI00027281 |
|---|---|
| IPI00194348 | |
| IPI00762242 | |
| IPI00795418 | |
| IPI00263726 | |
| IPI00778364 |
| Homologene ID | 74381 |
|---|
| RGD ID | 2711 |
|---|
| MGI ID | 95758 |
|---|