Elsevier Inc. cytoskeletal rearrangements Arp2/3 complex motor proteins Rhoq activating complex Rac1 effectors GEFs for Rac1 GEFs for Rab proteins Rabs at GSV Tbc1d4 Rab targets Rhoq Tbc1d4 Rab family mediated signaling pathway glucose ---> glucose uptake: heart, skeletal muscle, adipose tissue Akt2 insulin signaling pathway --+> phosphatidylinositol 3-kinase-Akt signaling pathway Limk1 Ssh1 Rac1 Rho/Rac/Cdc42 mediated signaling pathway GEFs for Rab proteins --+> Tbc1d4 Rab targets Akt2 ---| Tbc1d4 GEFs for Rab proteins --+> Rabs at GSV Tbc1d4 Rab targets ---> Rabs at GSV Lnpep ---- Tbc1d4 Lnpep glucose Rhoq ---| Rab31 Gapvd1 Cfl1 Recycling Slc2a4 glucose uptake: heart, skeletal muscle, adipose tissue insulin signaling pathway Akt2 --+> Myo5a Akt2 ---| Stxbp4 Stxbp4 phosphatidylinositol 3-kinase-Akt signaling pathway Tbc1d4 ---| Tbc1d4 Rab targets Myo5a phosphatidylinositol 3-kinase-Akt signaling pathway --+> Rab family mediated signaling pathway Stx4 ---- Stxbp4 Stxbp4 ---| Stx4 GEFs for Rac1 --+> Rac1 Rac1 ---> Rac1 effectors insulin signaling pathway --+> Rhoq activating complex phosphatidylinositol 3-kinase-Akt signaling pathway --+> Rac1 Arp2/3 complex ---> actin cycling actin cycling Cfl1 ---> actin cycling Ssh1 --+> Cfl1 Limk1 ---| Cfl1 Rhoq activating complex --+> Rhoq Rhoq ---- Trip10 Trip10 Gapvd1 ---- Trip10 Vamp2 Snap23 Stxbp3 Gapvd1 --+> Rab31 Stx4 Rab31 Slc2a4 Rab31 ---| Slc2a4