| URN | urn:agi-llid:1950 |
|---|---|
| Connectivity | 2449 |
| Name | Egf |
| Description | epidermal growth factor |
| Notes | This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants. |
| Pathway | EGFR -> AP-1/CREB/ELK-SRF/MYC signaling |
|---|---|
| EGFR -> NCOR2 signaling | |
| EGFR -> CTNND signaling | |
| EGFR -> SMAD1 signaling | |
| EGFR/ERBB -> STAT signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| EGFR/ERBB2 -> CTNNB signaling | |
| EGFR/ERBB2 -> HIF1A signaling | |
| EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling | |
| EGFR -> ZNF259 signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| pancreatic cancer pathway |
| GO Molecular Function | growth factor activity |
|---|---|
| epidermal growth factor receptor binding | |
| calcium ion binding | |
| transmembrane receptor protein tyrosine kinase activator activity |
| GO Cellular Component | extracellular region |
|---|---|
| membrane | |
| extracellular space | |
| soluble fraction | |
| plasma membrane | |
| platelet alpha granule lumen | |
| integral to membrane |
| GO Biological Process | positive regulation of cell proliferation |
|---|---|
| mammary gland alveolus development | |
| angiogenesis | |
| positive regulation of granule cell precursor proliferation | |
| branching morphogenesis of a tube | |
| signal transduction | |
| positive regulation of mitosis | |
| positive regulation of MAP kinase activity | |
| positive regulation of epidermal growth factor receptor activity | |
| regulation of protein secretion | |
| intracellular protein kinase cascade | |
| positive regulation of phosphorylation | |
| regulation of peptidyl-tyrosine phosphorylation | |
| activation of MAPKK activity | |
| DNA replication | |
| peptidyl-tyrosine phosphorylation | |
| negative regulation of secretion | |
| epidermal growth factor receptor signaling pathway |
| Ariadne Ontology | GF |
|---|
| Group | GF |
|---|---|
| extracellular region | |
| positive regulation of cell proliferation | |
| mammary gland alveolus development | |
| angiogenesis | |
| positive regulation of granule cell precursor proliferation | |
| branching morphogenesis of a tube | |
| signal transduction | |
| positive regulation of mitosis | |
| positive regulation of MAP kinase activity | |
| positive regulation of epidermal growth factor receptor activity | |
| regulation of protein secretion | |
| intracellular protein kinase cascade | |
| positive regulation of phosphorylation | |
| regulation of peptidyl-tyrosine phosphorylation | |
| activation of MAPKK activity | |
| DNA replication | |
| peptidyl-tyrosine phosphorylation | |
| negative regulation of secretion | |
| epidermal growth factor receptor signaling pathway | |
| growth factor activity | |
| epidermal growth factor receptor binding | |
| calcium ion binding | |
| transmembrane receptor protein tyrosine kinase activator activity | |
| membrane | |
| extracellular space | |
| soluble fraction | |
| plasma membrane | |
| platelet alpha granule lumen | |
| integral to membrane |
| MedScan ID | 1950 |
|---|
| Hugo ID | 3229 |
|---|
| Human chromosome position | 4q25 |
|---|
| LocusLink ID | 1950 |
|---|---|
| 13645 | |
| 25313 |
| Alias | URG |
|---|---|
| HOMG4 | |
| pro-epidermal growth factor | |
| beta-urogastrone | |
| AI790464 | |
| Pro-epidermal growth factor precursor (EGF) | |
| EGF | |
| EGF_HUMAN | |
| EGF_MOUSE | |
| epidermal growth factor | |
| epidermal growth factor (beta-urogastrone) | |
| LOC211904 | |
| urogastrone |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 131530 |
|---|---|
| 611718 |
| Mouse chromosome position | 3 65.2 cM |
|---|
| GO ID | 0005509 |
|---|---|
| 0005154 | |
| 0008083 | |
| 0030297 | |
| 0006260 | |
| 0000186 | |
| 0001525 | |
| 0048754 | |
| 0007173 | |
| 0060749 | |
| 0051048 | |
| 0043406 | |
| 0008284 | |
| 0045741 | |
| 0021940 | |
| 0045840 | |
| 0042327 | |
| 0050730 | |
| 0050708 | |
| 0007165 | |
| 0005576 | |
| 0005615 | |
| 0016021 | |
| 0005886 | |
| 0031093 | |
| 0005625 | |
| 0018108 | |
| 0016020 | |
| 0007243 |
| Rat chromosome position | 2q42-q43 |
|---|
| Swiss-Prot Accession | P01133 |
|---|---|
| Q6QBS2 | |
| P01132 | |
| Q3UWD7 | |
| Q569W5 | |
| Q8VD07 | |
| P07522 | |
| Q6P6T8 | |
| Q63183 | |
| Q52LZ6 |
| PIR ID | I52995 |
|---|---|
| A25531 |
| Unigene ID | Hs.419815 |
|---|---|
| Mm.252481 | |
| Rn.6075 |
| KEGG ID | hsa:1950 |
|---|---|
| mmu:13645 | |
| rno:25313 |
| Swiss-Prot ID | EGF_RAT |
|---|---|
| EGF_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Extracellular |
| IPI ID | IPI00231848 |
|---|---|
| IPI00000073 | |
| IPI00132121 | |
| IPI00890244 |
| Homologene ID | 1483 |
|---|
| RGD ID | 2542 |
|---|
| MGI ID | 95290 |
|---|