| URN | urn:agi-llid:7039 |
|---|---|
| Connectivity | 834 |
| Name | Tgfa |
| Description | transforming growth factor, alpha |
| Notes | Transforming growth factors (TGFs) are biologically active polypeptides that reversibly confer the transformed phenotype on cultured cells. TGF-alpha shows about 40% sequence homology with epidermal growth factor (EGF; MIM 131530) and competes with EGF for binding to the EGF receptor (MIM 131550), stimulating its phosphorylation and producing a mitogenic response.[supplied by OMIM] |
| Pathway | EGFR -> AP-1/CREB/ELK-SRF/MYC signaling |
|---|---|
| EGFR -> NCOR2 signaling | |
| EGFR -> CTNND signaling | |
| EGFR -> SMAD1 signaling | |
| EGFR/ERBB -> STAT signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| EGFR/ERBB2 -> CTNNB signaling | |
| EGFR/ERBB2 -> HIF1A signaling | |
| EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling | |
| EGFR -> ZNF259 signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| pancreatic cancer pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| glycoprotein binding | |
| growth factor activity | |
| epidermal growth factor receptor binding | |
| MAP kinase kinase activity |
| GO Cellular Component | extracellular region |
|---|---|
| cell surface | |
| membrane | |
| extracellular space | |
| plasma membrane | |
| nucleus | |
| integral to membrane | |
| integral to plasma membrane |
| GO Biological Process | cell proliferation |
|---|---|
| negative regulation of cellular process | |
| positive regulation of cell proliferation | |
| mammary gland alveolus development | |
| angiogenesis | |
| positive regulation of cell division | |
| positive regulation of mitosis | |
| positive regulation of epidermal growth factor receptor activity | |
| activation of MAPK activity | |
| positive regulation of protein amino acid phosphorylation | |
| positive regulation of epithelial cell proliferation | |
| negative regulation of neuron apoptosis | |
| anti-apoptosis | |
| neuroprotection | |
| cytosolic calcium ion homeostasis | |
| response to drug | |
| wound healing | |
| epidermal growth factor receptor signaling pathway |
| Ariadne Ontology | GF |
|---|
| Group | GF |
|---|---|
| extracellular region | |
| cell proliferation | |
| negative regulation of cellular process | |
| positive regulation of cell proliferation | |
| mammary gland alveolus development | |
| angiogenesis | |
| positive regulation of cell division | |
| positive regulation of mitosis | |
| positive regulation of epidermal growth factor receptor activity | |
| activation of MAPK activity | |
| positive regulation of protein amino acid phosphorylation | |
| positive regulation of epithelial cell proliferation | |
| negative regulation of neuron apoptosis | |
| anti-apoptosis | |
| neuroprotection | |
| cytosolic calcium ion homeostasis | |
| response to drug | |
| wound healing | |
| epidermal growth factor receptor signaling pathway | |
| signal transducer activity | |
| glycoprotein binding | |
| growth factor activity | |
| epidermal growth factor receptor binding | |
| MAP kinase kinase activity | |
| cell surface | |
| membrane | |
| extracellular space | |
| plasma membrane | |
| nucleus | |
| integral to membrane | |
| integral to plasma membrane |
| MedScan ID | 7039 |
|---|
| Hugo ID | 11765 |
|---|
| Human chromosome position | 2p13 |
|---|
| LocusLink ID | 7039 |
|---|---|
| 21802 | |
| 24827 |
| Alias | TFGA |
|---|---|
| protransforming growth factor alpha | |
| OTTHUMP00000203300 | |
| OTTHUMP00000203301 | |
| OTTHUMP00000203345 | |
| OTTHUMP00000203352 | |
| transforming growth factor-alpha | |
| wa1 | |
| wa-1 | |
| waved 1 | |
| TGFAA | |
| RATTGFAA | |
| 1MOX_D | |
| 1MOX_Ds | |
| EGF-like TGF | |
| ETGF | |
| LOC130089 | |
| LOC150914 | |
| TGF A | |
| Tgfa | |
| TGFA_HUMAN | |
| TGF-alpha | |
| Transforming growth factor alpha | |
| Transforming Growth Factor-alphahuman | |
| wa I | |
| waved I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 190170 |
|---|
| Mouse chromosome position | 6 35.8 cM |
|---|
| GO ID | 0004708 |
|---|---|
| 0005154 | |
| 0008083 | |
| 0004871 | |
| 0000187 | |
| 0008283 | |
| 0051781 | |
| 0045741 | |
| 0050679 | |
| 0045840 | |
| 0009986 | |
| 0005576 | |
| 0005615 | |
| 0016021 | |
| 0005886 | |
| 0001948 | |
| 0001525 | |
| 0006916 | |
| 0051480 | |
| 0007173 | |
| 0060749 | |
| 0048523 | |
| 0043524 | |
| 0043526 | |
| 0008284 | |
| 0001934 | |
| 0016020 | |
| 0005634 | |
| 0042493 | |
| 0042060 | |
| 0005887 |
| Rat chromosome position | 4q34 |
|---|
| Swiss-Prot Accession | P01135 |
|---|---|
| Q15578 | |
| Q6QBS1 | |
| Q9UE87 | |
| Q9UIS1 | |
| Q9UIS2 | |
| Q9UIS3 | |
| Q9UKM3 | |
| Q9UQ91 | |
| P48030 | |
| Q545E4 | |
| Q6LC37 | |
| P01134 | |
| Q63749 | |
| A8K286 | |
| Q15577 | |
| Q53SK7 | |
| Q9BS56 | |
| Q9UEI3 | |
| Q9UKM1 | |
| Q9UKM2 |
| PIR ID | A93356 |
|---|---|
| I57497 | |
| S27195 | |
| JN0876 |
| Unigene ID | Hs.170009 |
|---|---|
| Mm.137222 | |
| Rn.9952 |
| KEGG ID | hsa:7039 |
|---|---|
| mmu:21802 | |
| rno:24827 |
| Swiss-Prot ID | TGFA_RAT |
|---|---|
| TGFA_MOUSE | |
| TGFA_HUMAN | |
| Q545E4_MOUSE | |
| A8K286_HUMAN | |
| Q9BS56_HUMAN |
| Cell Localization | Secreted |
|---|---|
| extracellular space | |
| Cell membrane | |
| Extracellular |
| IPI ID | IPI00779017 |
|---|---|
| IPI00137996 | |
| IPI00465177 | |
| IPI00856067 | |
| IPI00872280 | |
| IPI00926333 | |
| IPI00954043 | |
| IPI00462181 | |
| IPI00327408 |
| Homologene ID | 2431 |
|---|
| RGD ID | 3849 |
|---|
| MGI ID | 98724 |
|---|