| URN | urn:agi-llid:6934 |
|---|---|
| Total Entities | 0 |
| Connectivity | 582 |
| Name | Tcf7l2 |
| Description | transcription factor 7-like 2 (T-cell specific, HMG-box) |
| Notes | This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010] |
| Ariadne Ontology | TCF-1 |
|---|---|
| Secreted proteins |
| GO Molecular Function | chromatin binding |
|---|---|
| gamma-catenin binding | |
| beta-catenin binding | |
| transcription factor binding | |
| nuclear hormone receptor binding | |
| protein kinase binding | |
| armadillo repeat domain binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription regulatory region DNA binding | |
| sequence-specific DNA binding transcription factor activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| transcription factor complex | |
| PML body | |
| beta-catenin-TCF7L2 complex | |
| protein-DNA complex | |
| cytosol | |
| nucleus |
| GO Biological Process | cell proliferation |
|---|---|
| cell cycle arrest | |
| negative regulation of fibroblast growth factor receptor signaling pathway | |
| negative regulation of canonical Wnt receptor signaling pathway | |
| negative regulation of BMP signaling pathway | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of insulin secretion | |
| regulation of insulin secretion involved in cellular response to glucose stimulus | |
| regulation of myelination | |
| Wnt receptor signaling pathway | |
| canonical Wnt receptor signaling pathway | |
| canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of heparan sulfate proteoglycan biosynthetic process | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| negative regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of fat cell differentiation | |
| somatic stem cell maintenance | |
| negative regulation of apoptotic process | |
| positive regulation of epithelial cell proliferation | |
| positive regulation of apoptotic process | |
| positive regulation of protein export from nucleus | |
| regulation of smooth muscle cell proliferation | |
| regulation of oligodendrocyte differentiation | |
| oligodendrocyte development | |
| neurogenesis | |
| fat cell differentiation | |
| generation of neurons | |
| myoblast cell fate commitment | |
| transcription, DNA-dependent | |
| maintenance of DNA repeat elements | |
| catenin import into nucleus | |
| secretory granule localization | |
| response to glucose stimulus | |
| negative regulation of organ growth | |
| regulation of skeletal muscle tissue development | |
| regulation of hormone metabolic process | |
| embryonic genitalia morphogenesis | |
| embryonic hindgut morphogenesis | |
| embryonic digestive tract morphogenesis | |
| face morphogenesis | |
| blood vessel development | |
| neural tube development | |
| pancreas development | |
| brain development | |
| pituitary gland development | |
| skin development | |
| bone mineralization | |
| odontogenesis of dentin-containing tooth | |
| glucose homeostasis | |
| positive regulation of protein binding |
| Pathway | pancreatic cancer pathway |
|---|
| Group | TCF-1 |
|---|---|
| cell proliferation | |
| cell cycle arrest | |
| negative regulation of fibroblast growth factor receptor signaling pathway | |
| negative regulation of canonical Wnt receptor signaling pathway | |
| negative regulation of BMP signaling pathway | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of insulin secretion | |
| regulation of insulin secretion involved in cellular response to glucose stimulus | |
| regulation of myelination | |
| Wnt receptor signaling pathway | |
| canonical Wnt receptor signaling pathway | |
| canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of heparan sulfate proteoglycan biosynthetic process | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| negative regulation of sequence-specific DNA binding transcription factor activity | |
| negative regulation of fat cell differentiation | |
| somatic stem cell maintenance | |
| negative regulation of apoptotic process | |
| positive regulation of epithelial cell proliferation | |
| positive regulation of apoptotic process | |
| positive regulation of protein export from nucleus | |
| regulation of smooth muscle cell proliferation | |
| regulation of oligodendrocyte differentiation | |
| oligodendrocyte development | |
| neurogenesis | |
| fat cell differentiation | |
| generation of neurons | |
| myoblast cell fate commitment | |
| transcription, DNA-dependent | |
| maintenance of DNA repeat elements | |
| catenin import into nucleus | |
| secretory granule localization | |
| response to glucose stimulus | |
| negative regulation of organ growth | |
| regulation of skeletal muscle tissue development | |
| regulation of hormone metabolic process | |
| embryonic genitalia morphogenesis | |
| embryonic hindgut morphogenesis | |
| embryonic digestive tract morphogenesis | |
| face morphogenesis | |
| blood vessel development | |
| neural tube development | |
| pancreas development | |
| brain development | |
| pituitary gland development | |
| skin development | |
| bone mineralization | |
| odontogenesis of dentin-containing tooth | |
| glucose homeostasis | |
| positive regulation of protein binding | |
| chromatin binding | |
| gamma-catenin binding | |
| beta-catenin binding | |
| transcription factor binding | |
| nuclear hormone receptor binding | |
| protein kinase binding | |
| armadillo repeat domain binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription regulatory region DNA binding | |
| sequence-specific DNA binding transcription factor activity | |
| nucleoplasm | |
| transcription factor complex | |
| PML body | |
| beta-catenin-TCF7L2 complex | |
| protein-DNA complex | |
| cytosol | |
| nucleus | |
| Secreted proteins |
| MedScan ID | 6934 |
|---|
| Hugo ID | 11641 |
|---|
| Human chromosome position | 10q25.3 |
|---|
| LocusLink ID | 6934 |
|---|---|
| 21416 | |
| 679869 |
| Alias | TCF4 |
|---|---|
| TCF-4 | |
| RP11-357H24.1 | |
| transcription factor 7-like 2 | |
| hTCF-4 | |
| T-cell factor 4 | |
| T-cell factor-4 variant A | |
| T-cell factor-4 variant B | |
| T-cell factor-4 variant C | |
| T-cell factor-4 variant D | |
| T-cell factor-4 variant E | |
| T-cell factor-4 variant F | |
| T-cell factor-4 variant G | |
| T-cell factor-4 variant H | |
| T-cell factor-4 variant I | |
| T-cell factor-4 variant J | |
| T-cell factor-4 variant K | |
| T-cell factor-4 variant L | |
| T-cell factor-4 variant M | |
| T-cell factor-4 variant X2 | |
| HMG box transcription factor 4 | |
| T-cell-specific transcription factor 4 | |
| TCF4B | |
| TCF4E | |
| mTcf-4B | |
| mTcf-4E | |
| mTCF-4 | |
| transcription factor 7-like 2, T-cell specific, HMG-box | |
| TCF7L2/TCF4 | |
| T-cell factor IV | |
| transcription factor IV | |
| TCF4/TCF7L2 | |
| Tcf7l2 | |
| transcription factor 4 | |
| transcription factor 4 isoform b | |
| transcription factor 7-like 2 (T-cell specific, HMG-box) | |
| transcription factor 7-like II | |
| OTTHUMP00000020496 | |
| OTTMUSP00000022196 | |
| OTTMUSP00000022202 | |
| HTcf IVs | |
| LOC679869 | |
| LOC683733 | |
| OTTMUSP00000022200 | |
| OTTMUSP00000022195 | |
| OTTMUSP00000022198 | |
| OTTMUSP00000022199 | |
| HTcf IV | |
| OTTMUSP00000022201 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602228 |
|---|---|
| 125853 |
| Unigene ID | Hs.593995 |
|---|---|
| Mm.139815 | |
| Rn.105849 |
| KEGG ID | hsa:6934 |
|---|---|
| mmu:21416 | |
| rno:679869 |
| Swiss-Prot Accession | Q9NQB0 |
|---|---|
| F8W7T5 | |
| C6ZRK5 | |
| B4DRJ8 | |
| C6ZRJ7 | |
| C6ZRK1 | |
| C6ZRJ8 | |
| C6ZRJ9 | |
| C6ZRK0 | |
| F8W742 | |
| C6ZRK2 | |
| B9X074 | |
| Q6FHW4 | |
| E9QQ91 | |
| Q924A0 | |
| Q8CAI6 | |
| E9Q990 | |
| Q8BS68 | |
| E9QQ90 | |
| D3YWT3 | |
| Q80WT9 | |
| O00185 | |
| Q9NQB1 | |
| Q9NQB2 | |
| Q9NQB3 | |
| Q9NQB4 | |
| Q9NQB5 | |
| Q9NQB6 | |
| Q9NQB7 | |
| Q9ULC2 | |
| O70574 | |
| Q8C834 | |
| Q91XP2 | |
| Q91XP3 | |
| Q91XP4 | |
| Q924A1 | |
| Q9Z0V3 | |
| Q9Z0V4 |
| GO ID | 0070016 |
|---|---|
| 0008013 | |
| 0003682 | |
| 0045295 | |
| 0035257 | |
| 0019901 | |
| 0043565 | |
| 0003700 | |
| 0008134 | |
| 0044212 | |
| 0001568 | |
| 0030282 | |
| 0007420 | |
| 0060070 | |
| 0044334 | |
| 0035411 | |
| 0007050 | |
| 0008283 | |
| 0048557 | |
| 0030538 | |
| 0048619 | |
| 0060325 | |
| 0045444 | |
| 0048699 | |
| 0042593 | |
| 0043570 | |
| 0048625 | |
| 0030514 | |
| 0043066 | |
| 0090090 | |
| 0045599 | |
| 0040037 | |
| 0046621 | |
| 0043433 | |
| 0000122 | |
| 0045892 | |
| 0021915 | |
| 0022008 | |
| 0042475 | |
| 0014003 | |
| 0031016 | |
| 0021983 | |
| 0043065 | |
| 0050679 | |
| 0010909 | |
| 0032024 | |
| 0032092 | |
| 0046827 | |
| 0051897 | |
| 0045944 | |
| 0032350 | |
| 0061178 | |
| 0031641 | |
| 0048713 | |
| 0048641 | |
| 0048660 | |
| 0006357 | |
| 0009749 | |
| 0032252 | |
| 0043588 | |
| 0035019 | |
| 0006351 | |
| 0016605 | |
| 0070369 | |
| 0005654 | |
| 0005634 | |
| 0032993 | |
| 0005667 | |
| 0003677 | |
| 0016055 | |
| 0045893 | |
| 0006355 | |
| 0005829 | |
| 0006916 |
| PIR ID | S22807 |
|---|
| Swiss-Prot ID | TF7L2_HUMAN |
|---|---|
| TF7L2_MOUSE |
| Cell Localization | Nucleus |
|---|---|
| PML body |
| IPI ID | IPI00164708 |
|---|---|
| IPI00221004 | |
| IPI00221005 | |
| IPI00221006 | |
| IPI00221007 | |
| IPI00221008 | |
| IPI00221009 | |
| IPI00221010 | |
| IPI00221011 | |
| IPI00335587 | |
| IPI00129307 | |
| IPI00224936 | |
| IPI00224938 | |
| IPI00224939 | |
| IPI00224941 | |
| IPI00830945 | |
| IPI00831494 | |
| IPI00831648 | |
| IPI00918384 |
| Mouse chromosome position | 19 53.0 cM |
|---|
| Rat chromosome position | 1q55 |
|---|
| Homologene ID | 7564 |
|---|
| MGI ID | 1202879 |
|---|
| RGD ID | 1583621 |
|---|
| Primary Cell Localization | Nucleus |
|---|