Protein Tgfa

URN	urn:agi-llid:7039
Total Entities	0
Connectivity	1426
Name	Tgfa
Description	transforming growth factor, alpha
Notes	Transforming growth factors (TGFs) are biologically active polypeptides that reversibly confer the transformed phenotype on cultured cells. TGF-alpha shows about 40% sequence homology with epidermal growth factor (EGF; MIM 131530) and competes with EGF for binding to the EGF receptor (MIM 131550), stimulating its phosphorylation and producing a mitogenic response.[supplied by OMIM]

Ariadne Ontology	GF
	Secreted proteins
	Biofluids assayable substances

GO Molecular Function	glycoprotein binding
	growth factor activity
	epidermal growth factor receptor binding
	MAP kinase kinase activity

GO Cellular Component	membrane
	extracellular region
	basolateral plasma membrane
	integral to plasma membrane
	integral to membrane
	plasma membrane
	cell surface
	perinuclear region of cytoplasm
	cytoplasmic vesicle
	nucleus
	extracellular space

GO Biological Process	cell proliferation
	negative regulation of cellular process
	positive regulation of mitosis
	positive regulation of epidermal growth factor-activated receptor activity
	activation of MAPK activity
	MAPK cascade
	epidermal growth factor receptor signaling pathway
	negative regulation of apoptotic process
	negative regulation of neuron apoptotic process
	positive regulation of cell division
	positive regulation of cell proliferation
	positive regulation of epithelial cell proliferation
	cytosolic calcium ion homeostasis
	response to drug
	wound healing
	angiogenesis
	mammary gland alveolus development

Pathway	EGFR -> AP-1/CREB/ELK-SRF/MYC signaling
	EGFR -> NCOR2 signaling
	EGFR/ERBB2 -> HIF1A signaling
	EGFR -> ZNF259 signaling
	EGFR -> AP-1/ATF2 signaling
	EGFR/ERBB2 -> TP53 signaling
	EGFR -> CTNND signaling
	EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling
	EGFR/ERBB2 -> CTNNB signaling
	EGFR -> SMAD1 signaling
	EGFR/ERBB -> STAT signaling
	NTF3 Expression Targets
	PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets
	Leptin/ELK-SRF Expression Targets
	Leptin/STAT Expression Targets
	NRG1/Catenin Expression Targets
	NRG1/STAT Expression Targets
	NRG1/AP-1/ATF Expression Targets
	NRG1/EP300/ETS/ETV/SP1 Expression Targets
	TGFA/CTNNB/CTNND Expression Targets
	TGFA/STAT Expression Targets
	TGFA/HIF1A Expression Targets
	TGFA/MEF/MYOD/NFATC Expression Targets
	TGFA/TP53 Expression Targets
	NRG1/CREB/CREBBP/ELK-SRF/MYC Expression Targets
	TGFA/CREB/CREBBP/ELK-SRF/MYC Expression Targets
	TGFA/FOXO3A Expression Targets
	IGF1/STAT Expression Targets
	Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets
	Insulin/STAT Expression Targets
	IL1A Expression Targets
	EGF/AP-1/ATF Expression Targets
	EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets
	EGF/MEF/MYOD/NFATC Expression Targets
	EGF/STAT Expression Targets
	IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets
	IGF1/MEF/MYOD/MYOG Expression Targets
	Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets
	Insulin/MEF/MYOD Expression Targets
	TGFA/AP-1/ATF Expression Targets
	IL1B Expression Targets
	EGF/CTNN Expression Targets
	pancreatic cancer pathway
	pancreatic cancer pathway

Group	GF
	cell proliferation
	negative regulation of cellular process
	positive regulation of mitosis
	positive regulation of epidermal growth factor-activated receptor activity
	activation of MAPK activity
	MAPK cascade
	epidermal growth factor receptor signaling pathway
	negative regulation of apoptotic process
	negative regulation of neuron apoptotic process
	positive regulation of cell division
	positive regulation of cell proliferation
	positive regulation of epithelial cell proliferation
	cytosolic calcium ion homeostasis
	response to drug
	wound healing
	angiogenesis
	mammary gland alveolus development
	glycoprotein binding
	growth factor activity
	epidermal growth factor receptor binding
	MAP kinase kinase activity
	membrane
	extracellular region
	basolateral plasma membrane
	integral to plasma membrane
	integral to membrane
	plasma membrane
	cell surface
	perinuclear region of cytoplasm
	cytoplasmic vesicle
	nucleus
	extracellular space
	Secreted proteins
	Biofluids assayable substances

MedScan ID	7039

Hugo ID	11765

Human chromosome position	2p13

Alias	TFGA
	protransforming growth factor alpha
	TGF-alpha
	wa1
	wa-1
	waved 1
	transforming growth factor-alpha
	TGFAA
	RATTGFAA
	tgfa
	TGFA_HUMAN
	waved I
	Transforming growth factor alpha
	TGF A
	Transforming Growth Factor-alphahuman
	wa I
	LOC130089
	1MOX_Ds
	OTTHUMP00000203300
	1MOX_D
	EGF-like TGF
	ETGF
	LOC150914
	OTTHUMP00000203301
	OTTHUMP00000203345
	OTTHUMP00000203352

OMIM ID	190170

Mouse chromosome position	6 35.8 cM

Rat chromosome position	4q34

Homologene ID	2431

MGI ID	98724

RGD ID	3849

Primary Cell Localization	Extracellular