| URN | urn:agi-llid:2737 |
|---|---|
| Total Entities | 0 |
| Connectivity | 295 |
| Name | Gli3 |
| Description | GLI family zinc finger 3 |
| Notes | This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq] |
| Ariadne Ontology | GLI-like |
|---|---|
| Oncogenes |
| GO Molecular Function | chromatin binding |
|---|---|
| beta-catenin binding | |
| histone acetyltransferase binding | |
| histone deacetylase binding | |
| nucleic acid binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| metal ion binding | |
| zinc ion binding | |
| sequence-specific DNA binding transcription factor activity |
| GO Cellular Component | nucleolus |
|---|---|
| mediator complex | |
| transcriptional repressor complex | |
| cell projection | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| intracellular membrane-bounded organelle | |
| nucleus | |
| cilium |
| GO Biological Process | negative regulation of smoothened signaling pathway |
|---|---|
| negative regulation of canonical Wnt receptor signaling pathway | |
| regulation of cell differentiation | |
| regulation of cell proliferation | |
| smoothened signaling pathway | |
| smoothened signaling pathway involved in dorsal-ventral neural tube patterning | |
| smoothened signaling pathway involved in spinal cord motor neuron cell fate specification | |
| smoothened signaling pathway involved in ventral spinal cord interneuron specification | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| negative regulation of cell differentiation | |
| negative regulation of cell proliferation | |
| negative regulation of neuron differentiation | |
| negative regulation of alpha-beta T cell differentiation | |
| negative regulation of apoptotic process | |
| positive regulation of neuroblast proliferation | |
| positive regulation of alpha-beta T cell differentiation | |
| positive regulation of osteoblast differentiation | |
| positive regulation of chondrocyte differentiation | |
| positive regulation of protein import into nucleus | |
| regulation of apoptotic process | |
| cell differentiation involved in kidney development | |
| T cell differentiation in thymus | |
| oligodendrocyte differentiation | |
| forebrain radial glial cell differentiation | |
| melanocyte differentiation | |
| neuron fate commitment | |
| transcription, DNA-dependent | |
| cerebral cortex radial glia guided migration | |
| thymocyte apoptotic process | |
| negative thymic T cell selection | |
| lateral ganglionic eminence cell proliferation | |
| response to estrogen stimulus | |
| axon guidance | |
| wound healing | |
| regulation of gene expression | |
| multicellular organismal development | |
| anatomical structure development | |
| pattern specification process | |
| anatomical structure formation involved in morphogenesis | |
| developmental growth | |
| embryonic digit morphogenesis | |
| embryonic digestive tract morphogenesis | |
| branching morphogenesis of a tube | |
| hindgut morphogenesis | |
| branching involved in ureteric bud morphogenesis | |
| mammary gland specification | |
| frontal suture morphogenesis | |
| lambdoid suture morphogenesis | |
| sagittal suture morphogenesis | |
| forebrain development | |
| pallium development | |
| subpallium development | |
| telencephalon development | |
| palate development | |
| tube development | |
| inner ear development | |
| neural tube development | |
| central nervous system development | |
| artery development | |
| brain development | |
| lung development | |
| kidney development | |
| heart development | |
| tongue development | |
| camera-type eye development | |
| metanephros development | |
| embryonic digestive tract development | |
| mammary gland development | |
| in utero embryonic development | |
| limb development | |
| anterior semicircular canal development | |
| lateral semicircular canal development | |
| dorsal-ventral pattern formation | |
| anterior-posterior pattern specification | |
| proximal-distal pattern formation | |
| forebrain dorsal-ventral pattern formation | |
| spinal cord dorsal-ventral patterning | |
| embryonic morphogenesis | |
| embryonic limb morphogenesis | |
| embryonic skeletal system morphogenesis | |
| nose morphogenesis | |
| camera-type eye morphogenesis | |
| odontogenesis of dentin-containing tooth | |
| optic nerve morphogenesis | |
| limb morphogenesis | |
| protein processing |
| Pathway | pancreatic cancer pathway |
|---|---|
| pancreatic cancer pathway |
| Group | GLI-like |
|---|---|
| Oncogenes | |
| negative regulation of smoothened signaling pathway | |
| negative regulation of canonical Wnt receptor signaling pathway | |
| regulation of cell differentiation | |
| regulation of cell proliferation | |
| smoothened signaling pathway | |
| smoothened signaling pathway involved in dorsal-ventral neural tube patterning | |
| smoothened signaling pathway involved in spinal cord motor neuron cell fate specification | |
| smoothened signaling pathway involved in ventral spinal cord interneuron specification | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| negative regulation of cell differentiation | |
| negative regulation of cell proliferation | |
| negative regulation of neuron differentiation | |
| negative regulation of alpha-beta T cell differentiation | |
| negative regulation of apoptotic process | |
| positive regulation of neuroblast proliferation | |
| positive regulation of alpha-beta T cell differentiation | |
| positive regulation of osteoblast differentiation | |
| positive regulation of chondrocyte differentiation | |
| positive regulation of protein import into nucleus | |
| regulation of apoptotic process | |
| cell differentiation involved in kidney development | |
| T cell differentiation in thymus | |
| oligodendrocyte differentiation | |
| forebrain radial glial cell differentiation | |
| melanocyte differentiation | |
| neuron fate commitment | |
| transcription, DNA-dependent | |
| cerebral cortex radial glia guided migration | |
| thymocyte apoptotic process | |
| negative thymic T cell selection | |
| lateral ganglionic eminence cell proliferation | |
| response to estrogen stimulus | |
| axon guidance | |
| wound healing | |
| regulation of gene expression | |
| multicellular organismal development | |
| anatomical structure development | |
| pattern specification process | |
| anatomical structure formation involved in morphogenesis | |
| developmental growth | |
| embryonic digit morphogenesis | |
| embryonic digestive tract morphogenesis | |
| branching morphogenesis of a tube | |
| hindgut morphogenesis | |
| branching involved in ureteric bud morphogenesis | |
| mammary gland specification | |
| frontal suture morphogenesis | |
| lambdoid suture morphogenesis | |
| sagittal suture morphogenesis | |
| forebrain development | |
| pallium development | |
| subpallium development | |
| telencephalon development | |
| palate development | |
| tube development | |
| inner ear development | |
| neural tube development | |
| central nervous system development | |
| artery development | |
| brain development | |
| lung development | |
| kidney development | |
| heart development | |
| tongue development | |
| camera-type eye development | |
| metanephros development | |
| embryonic digestive tract development | |
| mammary gland development | |
| in utero embryonic development | |
| limb development | |
| anterior semicircular canal development | |
| lateral semicircular canal development | |
| dorsal-ventral pattern formation | |
| anterior-posterior pattern specification | |
| proximal-distal pattern formation | |
| forebrain dorsal-ventral pattern formation | |
| spinal cord dorsal-ventral patterning | |
| embryonic morphogenesis | |
| embryonic limb morphogenesis | |
| embryonic skeletal system morphogenesis | |
| nose morphogenesis | |
| camera-type eye morphogenesis | |
| odontogenesis of dentin-containing tooth | |
| optic nerve morphogenesis | |
| limb morphogenesis | |
| protein processing | |
| chromatin binding | |
| beta-catenin binding | |
| histone acetyltransferase binding | |
| histone deacetylase binding | |
| nucleic acid binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| metal ion binding | |
| zinc ion binding | |
| sequence-specific DNA binding transcription factor activity | |
| nucleolus | |
| mediator complex | |
| transcriptional repressor complex | |
| cell projection | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| intracellular membrane-bounded organelle | |
| nucleus | |
| cilium |
| MedScan ID | 2737 |
|---|---|
| 140588 |
| Hugo ID | 4319 |
|---|
| Human chromosome position | 7p13 |
|---|
| LocusLink ID | 2737 |
|---|---|
| 14634 | |
| 140588 |
| Alias | PHS |
|---|---|
| ACLS | |
| GCPS | |
| PAPA | |
| PAPB | |
| PAP-A | |
| PAPA1 | |
| PPDIV | |
| GLI3FL | |
| GLI3-190 | |
| transcriptional activator GLI3 | |
| oncogene GLI3 | |
| zinc finger protein GLI3 | |
| GLI-Kruppel family member GLI3 | |
| glioma-associated oncogene family zinc finger 3 | |
| Xt | |
| Bph | |
| Pdn | |
| add | |
| AI854843 | |
| AU023367 | |
| extra toes | |
| brachyphalangy | |
| polydactyly Nagoya | |
| GLI3 form of 190 kDa | |
| GLI3 full length protein | |
| anterior digit pattern deformity | |
| GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome) | |
| PPD IV | |
| OTTHUMP00000025248 | |
| OTTHUMP00000159085 | |
| OTTMUSP00000029127 | |
| OTTMUSP00000029128 | |
| anterior digit pattern deformity mutant | |
| DNA-binding GLI3 | |
| extra toes mutant | |
| GLI family zinc finger 3 | |
| GLI3 | |
| DNA-binding protein |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 165240 |
|---|---|
| 200990 | |
| 175700 | |
| 241800 | |
| 146510 | |
| 174200 | |
| 174700 |
| Unigene ID | Hs.21509 |
|---|---|
| Mm.5098 | |
| Rn.199034 |
| KEGG ID | hsa:2737 |
|---|---|
| mmu:14634 | |
| rno:140588 |
| Swiss-Prot Accession | P10071 |
|---|---|
| B2RUG4 | |
| Q3TYX7 | |
| Q61602 | |
| A4D1W1 | |
| O75219 | |
| Q17RW4 | |
| Q75MT0 | |
| Q75MU9 | |
| Q9UDT5 | |
| Q9UJ39 | |
| Q3UMJ8 |
| GO ID | 0008013 |
|---|---|
| 0003682 | |
| 0035035 | |
| 0042826 | |
| 0043565 | |
| 0003700 | |
| 0008270 | |
| 0033077 | |
| 0060873 | |
| 0009952 | |
| 0060840 | |
| 0007411 | |
| 0001658 | |
| 0048593 | |
| 0061005 | |
| 0021801 | |
| 0048589 | |
| 0048566 | |
| 0048557 | |
| 0042733 | |
| 0048704 | |
| 0021798 | |
| 0021861 | |
| 0060364 | |
| 0007507 | |
| 0007442 | |
| 0001701 | |
| 0060366 | |
| 0022018 | |
| 0060875 | |
| 0035108 | |
| 0030324 | |
| 0060594 | |
| 0030318 | |
| 0001656 | |
| 0046639 | |
| 0043066 | |
| 0090090 | |
| 0008285 | |
| 0045665 | |
| 0045879 | |
| 0000122 | |
| 0045892 | |
| 0045060 | |
| 0043585 | |
| 0042475 | |
| 0048709 | |
| 0021631 | |
| 0060021 | |
| 0046638 | |
| 0032332 | |
| 0002052 | |
| 0045669 | |
| 0042307 | |
| 0045944 | |
| 0045893 | |
| 0016485 | |
| 0009954 | |
| 0060367 | |
| 0007224 | |
| 0060831 | |
| 0021776 | |
| 0021775 | |
| 0070242 | |
| 0043586 | |
| 0006351 | |
| 0005929 | |
| 0005737 | |
| 0005829 | |
| 0043231 | |
| 0016592 | |
| 0005730 | |
| 0005634 | |
| 0017053 | |
| 0003677 | |
| 0046872 | |
| 0003676 | |
| 0048856 | |
| 0048646 | |
| 0007420 | |
| 0048754 | |
| 0043010 | |
| 0007417 | |
| 0009953 | |
| 0030326 | |
| 0048598 | |
| 0030900 | |
| 0048839 | |
| 0001822 | |
| 0060173 | |
| 0030879 | |
| 0045596 | |
| 0021915 | |
| 0048663 | |
| 0021543 | |
| 0007389 | |
| 0042981 | |
| 0045595 | |
| 0042127 | |
| 0010468 | |
| 0006355 | |
| 0021513 | |
| 0021544 | |
| 0021537 | |
| 0035295 | |
| 0042995 | |
| 0005622 | |
| 0007275 | |
| 0043627 | |
| 0042060 | |
| 0016564 | |
| 0010552 | |
| 0045941 | |
| 0016481 | |
| 0032583 | |
| 0045449 | |
| 0006350 | |
| 0048558 | |
| 0070491 |
| PIR ID | A35927 |
|---|
| Swiss-Prot ID | GLI3_MOUSE |
|---|---|
| GLI3_HUMAN | |
| B2RUG4_MOUSE | |
| Q3TYX7_MOUSE |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm | |
| Cell projection | |
| cilium |
| IPI ID | IPI00123429 |
|---|---|
| IPI00018889 | |
| IPI00651982 | |
| IPI00857095 |
| Mouse chromosome position | 13 14.0 cM |
|---|
| Rat chromosome position | 17q12.1 |
|---|
| Homologene ID | 139 |
|---|
| MGI ID | 95729 |
|---|
| RGD ID | 620272 |
|---|
| Primary Cell Localization | Nucleus |
|---|