| URN | urn:agi-llid:1950 |
|---|---|
| Total Entities | 0 |
| Connectivity | 4056 |
| Name | Egf |
| Description | epidermal growth factor |
| Notes | This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants. |
| Ariadne Ontology | GF |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | growth factor activity |
|---|---|
| epidermal growth factor receptor binding | |
| calcium ion binding | |
| transmembrane receptor protein tyrosine kinase activator activity |
| GO Cellular Component | membrane |
|---|---|
| extracellular region | |
| platelet alpha granule lumen | |
| integral to membrane | |
| plasma membrane | |
| extracellular space |
| GO Biological Process | positive regulation of mitosis |
|---|---|
| negative regulation of epidermal growth factor receptor signaling pathway | |
| positive regulation of epidermal growth factor-activated receptor activity | |
| activation of MAPKK activity | |
| positive regulation of MAP kinase activity | |
| signal transduction | |
| intracellular protein kinase cascade | |
| ERK1 and ERK2 cascade | |
| epidermal growth factor receptor signaling pathway | |
| positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of phosphorylation | |
| positive regulation of peptidyl-threonine phosphorylation | |
| activation of transmembrane receptor protein tyrosine kinase activity | |
| regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of cell proliferation | |
| positive regulation of cerebellar granule cell precursor proliferation | |
| positive regulation of catenin import into nucleus | |
| regulation of protein secretion | |
| regulation of protein localization to cell surface | |
| regulation of calcium ion import | |
| platelet activation | |
| platelet degranulation | |
| DNA replication | |
| peptidyl-tyrosine phosphorylation | |
| STAT protein import into nucleus | |
| negative regulation of secretion | |
| negative regulation of cholesterol efflux | |
| positive regulation of hyaluronan biosynthetic process | |
| regulation of protein transport | |
| branching morphogenesis of a tube | |
| angiogenesis | |
| mammary gland alveolus development | |
| blood coagulation | |
| positive regulation of DNA binding |
| Pathway | EGFR -> AP-1/CREB/ELK-SRF/MYC signaling |
|---|---|
| EGFR -> NCOR2 signaling | |
| EGFR/ERBB2 -> HIF1A signaling | |
| EGFR -> ZNF259 signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| EGFR -> CTNND signaling | |
| EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling | |
| EGFR/ERBB2 -> CTNNB signaling | |
| EGFR -> SMAD1 signaling | |
| EGFR/ERBB -> STAT signaling | |
| Tamoxifen-Induced Endometrium Cancer | |
| EGF/HIF1A Expression Targets | |
| EGF/TP53 Expression Targets | |
| EREG/EP300/SP1 Expression Targets | |
| EGF/FOXO3A Expression Targets | |
| EGF/NCOR2 Expression Target | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/MEF/MYOD/NFATC Expression Targets | |
| EGF/STAT Expression Targets | |
| EGF/CTNN Expression Targets | |
| pancreatic cancer pathway | |
| pancreatic cancer pathway |
| Group | GF |
|---|---|
| positive regulation of mitosis | |
| negative regulation of epidermal growth factor receptor signaling pathway | |
| positive regulation of epidermal growth factor-activated receptor activity | |
| activation of MAPKK activity | |
| positive regulation of MAP kinase activity | |
| signal transduction | |
| intracellular protein kinase cascade | |
| ERK1 and ERK2 cascade | |
| epidermal growth factor receptor signaling pathway | |
| positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of phosphorylation | |
| positive regulation of peptidyl-threonine phosphorylation | |
| activation of transmembrane receptor protein tyrosine kinase activity | |
| regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of cell proliferation | |
| positive regulation of cerebellar granule cell precursor proliferation | |
| positive regulation of catenin import into nucleus | |
| regulation of protein secretion | |
| regulation of protein localization to cell surface | |
| regulation of calcium ion import | |
| platelet activation | |
| platelet degranulation | |
| DNA replication | |
| peptidyl-tyrosine phosphorylation | |
| STAT protein import into nucleus | |
| negative regulation of secretion | |
| negative regulation of cholesterol efflux | |
| positive regulation of hyaluronan biosynthetic process | |
| regulation of protein transport | |
| branching morphogenesis of a tube | |
| angiogenesis | |
| mammary gland alveolus development | |
| blood coagulation | |
| positive regulation of DNA binding | |
| growth factor activity | |
| epidermal growth factor receptor binding | |
| calcium ion binding | |
| transmembrane receptor protein tyrosine kinase activator activity | |
| membrane | |
| extracellular region | |
| platelet alpha granule lumen | |
| integral to membrane | |
| plasma membrane | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 1950 |
|---|
| Hugo ID | 3229 |
|---|
| Human chromosome position | 4q25 |
|---|
| LocusLink ID | 1950 |
|---|---|
| 13645 | |
| 25313 |
| Alias | URG |
|---|---|
| HOMG4 | |
| pro-epidermal growth factor | |
| beta-urogastrone | |
| AI790464 | |
| Pro-epidermal growth factor precursor (EGF) | |
| epidermal growth factor (beta-urogastrone) | |
| urogastrone | |
| EGF_MOUSE | |
| EGF_HUMAN | |
| EGF | |
| epidermal growth factor | |
| LOC211904 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 131530 |
|---|---|
| 611718 |
| Unigene ID | Hs.419815 |
|---|---|
| Mm.252481 | |
| Rn.6075 |
| KEGG ID | hsa:1950 |
|---|---|
| mmu:13645 | |
| rno:25313 |
| Swiss-Prot Accession | E7EVD2 |
|---|---|
| P01133 | |
| P01132 | |
| P07522 | |
| Q63183 | |
| B4DRK7 | |
| E9PBF0 | |
| Q52LZ6 | |
| E9QNX6 | |
| Q569W5 | |
| Q6P9J2 | |
| Q6QBS2 | |
| Q3UWD7 | |
| Q8VD07 | |
| Q6P6T8 |
| GO ID | 0005509 |
|---|---|
| 0005154 | |
| 0008083 | |
| 0030297 | |
| 0006260 | |
| 0070371 | |
| 0007262 | |
| 0000186 | |
| 0007171 | |
| 0001525 | |
| 0007596 | |
| 0048754 | |
| 0007173 | |
| 0060749 | |
| 0090370 | |
| 0042059 | |
| 0051048 | |
| 0018108 | |
| 0030168 | |
| 0002576 | |
| 0043388 | |
| 0043406 | |
| 0035413 | |
| 0008284 | |
| 0021940 | |
| 0045741 | |
| 1900127 | |
| 0045840 | |
| 0010800 | |
| 0042327 | |
| 2000060 | |
| 0045893 | |
| 0090279 | |
| 2000008 | |
| 0050708 | |
| 0007165 | |
| 0005576 | |
| 0005615 | |
| 0016021 | |
| 0005886 | |
| 0031093 | |
| 0050730 | |
| 0051223 | |
| 0016020 | |
| 0007243 | |
| 0005625 |
| PIR ID | I52995 |
|---|---|
| A25531 |
| Swiss-Prot ID | EGF_RAT |
|---|---|
| EGF_HUMAN | |
| EGF_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Extracellular |
| IPI ID | IPI00231848 |
|---|---|
| IPI00000073 | |
| IPI00966866 | |
| IPI00132121 | |
| IPI00890244 |
| Mouse chromosome position | 3 65.2 cM |
|---|
| Rat chromosome position | 2q42-q43 |
|---|
| Homologene ID | 1483 |
|---|
| MGI ID | 95290 |
|---|
| RGD ID | 2542 |
|---|
| Primary Cell Localization | Extracellular |
|---|