| URN | urn:agi-llid:4088 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1600 |
| Name | Smad3 |
| Description | MAD homolog 3 (Drosophila) |
| Notes | transcription factor; important component of the TGF-beta signaling pathway [RGD] |
| Ariadne Ontology | SMAD |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | protein binding transcription factor activity |
|---|---|
| chromatin binding | |
| SMAD binding | |
| collagen binding | |
| beta-catenin binding | |
| transcription factor binding | |
| RNA polymerase II activating transcription factor binding | |
| transforming growth factor beta receptor binding | |
| phosphatase binding | |
| protein kinase binding | |
| ubiquitin protein ligase binding | |
| ubiquitin binding | |
| protein homodimerization activity | |
| co-SMAD binding | |
| R-SMAD binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| core promoter proximal region sequence-specific DNA binding | |
| double-stranded DNA binding | |
| chromatin DNA binding | |
| transcription regulatory region DNA binding | |
| metal ion binding | |
| zinc ion binding | |
| sequence-specific DNA binding transcription factor activity | |
| transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity |
| GO Cellular Component | nuclear inner membrane |
|---|---|
| nucleoplasm | |
| transcription factor complex | |
| protein complex | |
| SMAD protein complex | |
| receptor complex | |
| plasma membrane | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | evasion or tolerance of host defenses by virus |
|---|---|
| cell cycle arrest | |
| negative regulation of mitotic cell cycle | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| positive regulation of canonical Wnt receptor signaling pathway | |
| regulation of transforming growth factor beta receptor signaling pathway | |
| activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| activin receptor signaling pathway | |
| nodal signaling pathway | |
| negative regulation of cell growth | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of protein phosphorylation | |
| regulation of transcription, DNA-dependent | |
| positive regulation of alkaline phosphatase activity | |
| negative regulation of cell proliferation | |
| negative regulation of osteoblast differentiation | |
| negative regulation of osteoblast proliferation | |
| negative regulation of apoptotic process | |
| positive regulation of cell migration | |
| positive regulation of chondrocyte differentiation | |
| positive regulation of epithelial to mesenchymal transition | |
| positive regulation of stress fiber assembly | |
| positive regulation of focal adhesion assembly | |
| induction of apoptosis | |
| positive regulation of transcription factor import into nucleus | |
| positive regulation of catenin import into nucleus | |
| regulation of epithelial cell proliferation | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| positive regulation of gene expression involved in extracellular matrix organization | |
| osteoblast development | |
| transdifferentiation | |
| lens fiber cell differentiation | |
| osteoblast differentiation | |
| T cell activation | |
| transcription, DNA-dependent | |
| transcription from RNA polymerase II promoter | |
| transcription initiation from RNA polymerase II promoter | |
| primary miRNA processing | |
| cell-cell junction organization | |
| SMAD protein complex assembly | |
| apoptotic mitochondrial changes | |
| release of cytochrome c from mitochondria | |
| immune response | |
| immune system development | |
| regulation of immune response | |
| positive regulation of positive chemotaxis | |
| response to hypoxia | |
| negative regulation of inflammatory response | |
| wound healing | |
| negative regulation of wound healing | |
| negative regulation of protein catabolic process | |
| positive regulation of interleukin-1 beta production | |
| positive regulation of transforming growth factor beta3 production | |
| regulation of transforming growth factor beta2 production | |
| positive regulation of bone mineralization | |
| regulation of striated muscle tissue development | |
| protein stabilization | |
| developmental growth | |
| embryonic foregut morphogenesis | |
| heart looping | |
| somitogenesis | |
| mesoderm formation | |
| skeletal system development | |
| ureteric bud development | |
| liver development | |
| thyroid gland development | |
| endoderm development | |
| pericardium development | |
| in utero embryonic development | |
| embryonic pattern specification | |
| gastrulation | |
| embryonic cranial skeleton morphogenesis | |
| paraxial mesoderm morphogenesis | |
| transport | |
| gene expression | |
| regulation of binding |
| Pathway | Cell Cycle |
|---|---|
| Notch -> SMAD3 signaling | |
| TGFBR -> MEF/MYOD/MYOG signaling | |
| ActivinR -> SMAD2/3 signaling | |
| TGFBR/BMPR -> SMAD2/3 signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| Dexamethasone-Induced Osteoporosis | |
| ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy | |
| BMP7-ACVR2 Expression Targets | |
| INHBA-ACVR2/ACVR1 Expression Targets | |
| MSTN-ACVR2/ACVR1 Expression Targets | |
| INHBB-ACVR2 Expression Target | |
| BMP6-ACVR2A Expression Targets | |
| NODAL-ACVR2B Expression Targets | |
| TGFB2-TGFBR1 Expression Targets | |
| TGFB3-TGFBR1 Expression Targets | |
| BDNF Expression Targets | |
| NTF3 Expression Targets | |
| NTF4 Expression Targets | |
| ADAM17 Expression Targets | |
| NGF/SMAD3/NF-kB Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| FGF2/STAT Expression Targets | |
| NOTCH Expression Targets | |
| TGFB1-TGFBR1 Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/STAT Expression Targets | |
| TGFB1-ACVRL1 Expression Targets | |
| TGFB1-TGFBR1/AP-1 Expression Targets | |
| EGF/CTNN Expression Targets | |
| pancreatic cancer pathway | |
| transforming growth factor-beta Smad dependent signaling pathway | |
| colorectal cancer pathway | |
| colorectal cancer pathway | |
| pancreatic cancer pathway |
| Group | SMAD |
|---|---|
| evasion or tolerance of host defenses by virus | |
| cell cycle arrest | |
| negative regulation of mitotic cell cycle | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| positive regulation of canonical Wnt receptor signaling pathway | |
| regulation of transforming growth factor beta receptor signaling pathway | |
| activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| activin receptor signaling pathway | |
| nodal signaling pathway | |
| negative regulation of cell growth | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of protein phosphorylation | |
| regulation of transcription, DNA-dependent | |
| positive regulation of alkaline phosphatase activity | |
| negative regulation of cell proliferation | |
| negative regulation of osteoblast differentiation | |
| negative regulation of osteoblast proliferation | |
| negative regulation of apoptotic process | |
| positive regulation of cell migration | |
| positive regulation of chondrocyte differentiation | |
| positive regulation of epithelial to mesenchymal transition | |
| positive regulation of stress fiber assembly | |
| positive regulation of focal adhesion assembly | |
| induction of apoptosis | |
| positive regulation of transcription factor import into nucleus | |
| positive regulation of catenin import into nucleus | |
| regulation of epithelial cell proliferation | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| positive regulation of gene expression involved in extracellular matrix organization | |
| osteoblast development | |
| transdifferentiation | |
| lens fiber cell differentiation | |
| osteoblast differentiation | |
| T cell activation | |
| transcription, DNA-dependent | |
| transcription from RNA polymerase II promoter | |
| transcription initiation from RNA polymerase II promoter | |
| primary miRNA processing | |
| cell-cell junction organization | |
| SMAD protein complex assembly | |
| apoptotic mitochondrial changes | |
| release of cytochrome c from mitochondria | |
| immune response | |
| immune system development | |
| regulation of immune response | |
| positive regulation of positive chemotaxis | |
| response to hypoxia | |
| negative regulation of inflammatory response | |
| wound healing | |
| negative regulation of wound healing | |
| negative regulation of protein catabolic process | |
| positive regulation of interleukin-1 beta production | |
| positive regulation of transforming growth factor beta3 production | |
| regulation of transforming growth factor beta2 production | |
| positive regulation of bone mineralization | |
| regulation of striated muscle tissue development | |
| protein stabilization | |
| developmental growth | |
| embryonic foregut morphogenesis | |
| heart looping | |
| somitogenesis | |
| mesoderm formation | |
| skeletal system development | |
| ureteric bud development | |
| liver development | |
| thyroid gland development | |
| endoderm development | |
| pericardium development | |
| in utero embryonic development | |
| embryonic pattern specification | |
| gastrulation | |
| embryonic cranial skeleton morphogenesis | |
| paraxial mesoderm morphogenesis | |
| transport | |
| gene expression | |
| regulation of binding | |
| protein binding transcription factor activity | |
| chromatin binding | |
| SMAD binding | |
| collagen binding | |
| beta-catenin binding | |
| transcription factor binding | |
| RNA polymerase II activating transcription factor binding | |
| transforming growth factor beta receptor binding | |
| phosphatase binding | |
| protein kinase binding | |
| ubiquitin protein ligase binding | |
| ubiquitin binding | |
| protein homodimerization activity | |
| co-SMAD binding | |
| R-SMAD binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| core promoter proximal region sequence-specific DNA binding | |
| double-stranded DNA binding | |
| chromatin DNA binding | |
| transcription regulatory region DNA binding | |
| metal ion binding | |
| zinc ion binding | |
| sequence-specific DNA binding transcription factor activity | |
| transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity | |
| nuclear inner membrane | |
| nucleoplasm | |
| transcription factor complex | |
| protein complex | |
| SMAD protein complex | |
| receptor complex | |
| plasma membrane | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|
| MedScan ID | 4088 |
|---|
| Hugo ID | 6769 |
|---|
| Human chromosome position | 15q22.33 |
|---|
| LocusLink ID | 4088 |
|---|---|
| 17127 | |
| 25631 | |
| 102679 | |
| 51521 | |
| 25856 |
| Alias | LDS3 |
|---|---|
| LDS1C | |
| MADH3 | |
| JV15-2 | |
| HSPC193 | |
| HsT17436 | |
| mothers against decapentaplegic homolog 3 | |
| mad3 | |
| hMAD-3 | |
| hSMAD3 | |
| MAD homolog 3 | |
| mad homolog JV15-2 | |
| mad protein homolog | |
| mothers against DPP homolog 3 | |
| SMA- and MAD-related protein 3 | |
| SMAD, mothers against DPP homolog 3 | |
| MAD, mothers against decapentaplegic homolog 3 | |
| AU022421 | |
| RP23-63E8.1 | |
| mMad3 | |
| Smad 3 | |
| MAD (mothers against decapentaplegic, Drosophila) homolog 3 | |
| Mothers against decapentaplegic homolog 3 (SMAD 3) | |
| MGC60396 | |
| MAD homolog III | |
| Mothers against decapentaplegic, drosophila, homolog of, 3 | |
| MAD, mothers against decapentaplegic homolog 3 (Drosophila) | |
| Mothers against decapentaplegic, drosophila, homolog of, III | |
| Mothers against DPP homolog III | |
| OTTMUSP00000023917 | |
| OTTMUSP00000023918 | |
| MAD (mothers against decapentaplegic, Drosophila) homolog III | |
| SMAD, mothers against DPP homolog III | |
| homolog of Drosophila Mothers against decapentaplegic III | |
| MAD homolog 3 (Drosophila) | |
| DKFZP586N0721 | |
| DKFZp686J10186 | |
| homolog of Drosophila Mothers against decapentaplegic 3 | |
| MAD (mothers against decapentaplegic homolog III | |
| MAD (mothers against decapentaplegic homolog 3 | |
| JV15-Ls | |
| JV15-L | |
| JV15 II | |
| SMAD family member 3 | |
| Mothers against DPP homolog III | |
| Mothers against DPP homolog 3 | |
| SMAD3 | |
| JV15-2s | |
| hSMAD3s | |
| expressed sequence AU022421 | |
| MAD (mothers against decapentaplegic Drosophila) homolog 3 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603109 |
|---|---|
| 613795 |
| Unigene ID | Hs.727986 |
|---|---|
| Mm.7320 | |
| Rn.10636 | |
| Hs.36915 | |
| Hs.714621 | |
| Hs.618504 | |
| Hs.702172 | |
| Hs.555881 |
| KEGG ID | hsa:4088 |
|---|---|
| mmu:17127 | |
| rno:25631 |
| Swiss-Prot Accession | P84022 |
|---|---|
| F5H383 | |
| Q9P0T0 | |
| B1B1A2 | |
| Q8BUN5 | |
| P84025 | |
| O09064 | |
| O09144 | |
| O14510 | |
| O35273 | |
| Q8BX84 | |
| Q92940 | |
| Q93002 | |
| Q9GKR4 | |
| A8K4B6 | |
| B7Z4Z5 | |
| B7Z9Q2 | |
| Q59F45 | |
| Q68DS8 | |
| Q05CN3 | |
| Q3V3E0 | |
| Q206L0 | |
| Q7L4U6 |
| GO ID | 0070412 |
|---|---|
| 0001102 | |
| 0008013 | |
| 0031490 | |
| 0070410 | |
| 0005518 | |
| 0000987 | |
| 0003690 | |
| 0019902 | |
| 0000988 | |
| 0042803 | |
| 0019901 | |
| 0043565 | |
| 0003700 | |
| 0008134 | |
| 0044212 | |
| 0005160 | |
| 0030618 | |
| 0043130 | |
| 0031625 | |
| 0008270 | |
| 0007183 | |
| 0042110 | |
| 0006919 | |
| 0008633 | |
| 0032924 | |
| 0007050 | |
| 0045216 | |
| 0048589 | |
| 0048701 | |
| 0048617 | |
| 0009880 | |
| 0007492 | |
| 0019049 | |
| 0010467 | |
| 0001947 | |
| 0006955 | |
| 0002520 | |
| 0001701 | |
| 0006917 | |
| 0070306 | |
| 0001889 | |
| 0001707 | |
| 0043066 | |
| 0030308 | |
| 0050728 | |
| 0045930 | |
| 0045668 | |
| 0033689 | |
| 0042177 | |
| 0001933 | |
| 0000122 | |
| 0030512 | |
| 0061045 | |
| 0038092 | |
| 0002076 | |
| 0048340 | |
| 0060039 | |
| 0010694 | |
| 0030501 | |
| 0090263 | |
| 0035413 | |
| 0030335 | |
| 0032332 | |
| 0010718 | |
| 0051894 | |
| 1901313 | |
| 0032731 | |
| 0050927 | |
| 0051496 | |
| 0042993 | |
| 0045944 | |
| 0045893 | |
| 0032916 | |
| 0031053 | |
| 0050821 | |
| 0051098 | |
| 0050678 | |
| 0050776 | |
| 0016202 | |
| 0017015 | |
| 0032909 | |
| 0001836 | |
| 0001666 | |
| 0001756 | |
| 0030878 | |
| 0006367 | |
| 0006351 | |
| 0060290 | |
| 0007179 | |
| 0006810 | |
| 0001657 | |
| 0042060 | |
| 0071141 | |
| 0005737 | |
| 0005829 | |
| 0005637 | |
| 0005654 | |
| 0005634 | |
| 0005886 | |
| 0043235 | |
| 0005667 | |
| 0003677 | |
| 0046332 | |
| 0003682 | |
| 0046872 | |
| 0008637 | |
| 0007369 | |
| 0008285 | |
| 0001649 | |
| 0006355 | |
| 0001501 | |
| 0006366 | |
| 0005622 | |
| 0043234 | |
| 0097296 | |
| 0003706 | |
| 0010843 | |
| 0016566 | |
| 0016563 | |
| 0010553 | |
| 0010552 | |
| 0045941 | |
| 0045449 | |
| 0006350 | |
| 0015460 | |
| 0005515 | |
| 0007182 | |
| 0009887 |
| PIR ID | S71798 |
|---|
| Swiss-Prot ID | SMAD3_MOUSE |
|---|---|
| SMAD3_RAT | |
| SMAD3_HUMAN | |
| Q9P0T0_HUMAN | |
| B1B1A2_MOUSE | |
| B7Z4Z5_HUMAN | |
| B7Z9Q2_HUMAN | |
| A8K4B6_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| IPI ID | IPI00314870 |
|---|---|
| IPI00209246 | |
| IPI00024305 | |
| IPI00922698 | |
| IPI00383289 | |
| IPI00922059 | |
| IPI00022808 | |
| IPI00808484 | |
| IPI00875319 | |
| IPI00831542 | |
| IPI00830220 | |
| IPI00830323 |
| Mouse chromosome position | 9 |
|---|
| Rat chromosome position | 8q24 |
|---|
| Homologene ID | 55937 |
|---|
| MGI ID | 1201674 |
|---|---|
| 2143216 |
| RGD ID | 3032 |
|---|
| Primary Cell Localization | Nucleus |
|---|