Protein Gli1

URN	urn:agi-llid:2735
Total Entities	0
Connectivity	591
Name	Gli1
Description	GLI family zinc finger 1
Notes	This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Ariadne Ontology	GLI-like
	Oncogenes
	Secreted proteins
	Biofluids assayable substances

GO Molecular Function	chromatin binding
	microtubule binding
	nucleic acid binding
	DNA binding
	transcription regulatory region DNA binding
	metal ion binding
	zinc ion binding
	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

GO Biological Process	regulation of smoothened signaling pathway
	negative regulation of canonical Wnt receptor signaling pathway
	positive regulation of smoothened signaling pathway
	signal transduction
	smoothened signaling pathway
	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
	positive regulation of transcription, DNA-dependent
	positive regulation of DNA replication
	positive regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	positive regulation of cell proliferation
	cell differentiation
	epidermal cell differentiation
	osteoblast differentiation
	transcription, DNA-dependent
	multicellular organismal development
	cerebellar cortex morphogenesis
	notochord regression
	ventral midline development
	lung development
	pituitary gland development
	dorsal-ventral pattern formation
	proximal-distal pattern formation
	digestive tract morphogenesis
	spermatogenesis

Pathway	pancreatic cancer pathway
	pancreatic cancer pathway

Group	GLI-like
	Oncogenes
	regulation of smoothened signaling pathway
	negative regulation of canonical Wnt receptor signaling pathway
	positive regulation of smoothened signaling pathway
	signal transduction
	smoothened signaling pathway
	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
	positive regulation of transcription, DNA-dependent
	positive regulation of DNA replication
	positive regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	positive regulation of cell proliferation
	cell differentiation
	epidermal cell differentiation
	osteoblast differentiation
	transcription, DNA-dependent
	multicellular organismal development
	cerebellar cortex morphogenesis
	notochord regression
	ventral midline development
	lung development
	pituitary gland development
	dorsal-ventral pattern formation
	proximal-distal pattern formation
	digestive tract morphogenesis
	spermatogenesis
	chromatin binding
	microtubule binding
	nucleic acid binding
	DNA binding
	transcription regulatory region DNA binding
	metal ion binding
	zinc ion binding
	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
	intracellular
	cytoplasm
	cytosol
	nucleus
	cilium
	Secreted proteins
	Biofluids assayable substances

MedScan ID	2735

Hugo ID	4317

Human chromosome position	12q13.2-q13.3

Alias	GLI
	zinc finger protein GLI1
	oncogene GLI
	glioma-associated oncogene 1
	glioma-associated oncogene homolog 1 (zinc finger protein)
	Zfp5
	Zfp-5
	AV235269
	zinc finger protein 5
	glioma-associated oncogene homolog
	GLI-Kruppel family member GLI1
	glioma-associated oncogene homolog (zinc finger protein)
	glioma-associated oncogene homolog 1
	glioma-associated oncogene homolog I
	GLI1
	Zinc finger protein GLI I
	Glioma-associated oncogene
	GLI-Kruppel family member GLI
	GLI I
	GLI family zinc finger 1
	glioma-associated oncogene family zinc finger 1

OMIM ID	165220

PIR ID	S00672

Cell Localization	Cytoplasm
	Nucleus

Mouse chromosome position	10 69.0 cM

Rat chromosome position	7q22

Homologene ID	3859

MGI ID	95727

RGD ID	621673

Primary Cell Localization	Nucleus