Protein Arid1a

URN	urn:agi-llid:8289
Total Entities	0
Connectivity	96
Name	Arid1a
Description	AT rich interactive domain 1A (SWI-like)
Notes	This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Ariadne Ontology	Chromatin remodeling

GO Molecular Function	ligand-dependent nuclear receptor binding
	DNA binding
	transcription coactivator activity

GO Biological Process	intracellular estrogen receptor signaling pathway
	androgen receptor signaling pathway
	glucocorticoid receptor signaling pathway
	positive regulation of transcription, DNA-dependent
	chromatin-mediated maintenance of transcription
	regulation of transcription, DNA-dependent
	regulation of transcription from RNA polymerase II promoter
	transcription, DNA-dependent
	nucleosome disassembly
	chromatin organization
	chromatin modification
	nucleosome mobilization
	chromatin remodeling
	nervous system development

Pathway	SWI/SNF BRG1/BAF Chromatin Remodeling
	SWI/SNF BRM/BAF Chromatin Remodeling
	pancreatic cancer pathway

Group	Chromatin remodeling
	intracellular estrogen receptor signaling pathway
	androgen receptor signaling pathway
	glucocorticoid receptor signaling pathway
	positive regulation of transcription, DNA-dependent
	chromatin-mediated maintenance of transcription
	regulation of transcription, DNA-dependent
	regulation of transcription from RNA polymerase II promoter
	transcription, DNA-dependent
	nucleosome disassembly
	chromatin organization
	chromatin modification
	nucleosome mobilization
	chromatin remodeling
	nervous system development
	ligand-dependent nuclear receptor binding
	DNA binding
	transcription coactivator activity
	nucleolus
	npBAF complex
	nBAF complex
	SWI-SNF complex
	nuclear chromatin
	intracellular
	nucleus

MedScan ID	8289

Hugo ID	11110

Human chromosome position	1p35.3

Alias	ELD
	B120
	OSA1
	P270
	hELD
	BM029
	MRD14
	hOSA1
	BAF250
	C1orf4
	BAF250a
	SMARCF1
	RP1-50O24.1
	AT-rich interactive domain-containing protein 1A
	osa homolog 1
	SWI-like protein
	brain protein 120
	OSA1 nuclear protein
	BRG1-associated factor 250a
	SWI/SNF complex protein p270
	chromatin remodeling factor p250
	ARID domain-containing protein 1A
	SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1
	1110030E03Rik
	RP23-463N9.3
	Swi1 like
	BRG1-associated factor 250
	SWI-SNF complex protein p270
	AT rich interactive domain 1A (Swi1 like)
	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1
	OTTHUMP00000044975
	uncharacterized bone marrow protein BM029
	LOC669477
	Osa I
	OTTHUMP00000004117
	OTTHUMP00000004118
	OTTHUMP00000004119
	OTTMUSP00000011855
	OTTMUSP00000011856
	OTTMUSP00000011857
	OTTMUSP00000011924
	Smarcf I
	chromosome 1 open reading frame IV
	CG1368-PA
	ARID1A
	at rich interactive domain 1a
	AT rich interactive domain 1A (SWI- like)
	Brahma-associated factor 250
	Brahma-associated factor 250a
	1110030E03
	chromosome 1 open reading frame 4
	brm-associated factor 250a
	brm-associated factor 250
	BRG1/Brahma-associated factor 250
	BRG1/brm-associated factor 250a
	BRG1/brm-associated factor 250
	BRG1/Brahma-associated factor 250a

OMIM ID	603024
	614607

PIR ID	T00022

Swiss-Prot ID	ARI1A_HUMAN
	ARI1A_MOUSE

Cell Localization	Nucleus

Mouse chromosome position	4

Rat chromosome position	5q36

Homologene ID	21216

MGI ID	1935147

RGD ID	1310500

Primary Cell Localization	Nucleus