| URN | urn:agi-llid:86 |
|---|---|
| Total Entities | 0 |
| Connectivity | 55 |
| Name | Actl6a |
| Description | actin-like 6A |
| Notes | This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Chromatin remodeling |
|---|---|
| DNA replication |
| GO Molecular Function | chromatin binding |
|---|---|
| ATP binding | |
| transcription coactivator activity |
| GO Cellular Component | chromatin remodeling complex |
|---|---|
| Ino80 complex | |
| npBAF complex | |
| SWI-SNF complex | |
| NuA4 histone acetyltransferase complex | |
| plasma membrane | |
| nucleus |
| GO Biological Process | signal transduction |
|---|---|
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| transcription, DNA-dependent | |
| DNA repair | |
| DNA recombination | |
| histone H2A acetylation | |
| histone H4 acetylation | |
| response to DNA damage stimulus | |
| chromatin modification | |
| chromatin remodeling | |
| regulation of growth | |
| neural retina development | |
| nervous system development |
| Pathway | SWI/SNF BRG1/BAF Chromatin Remodeling |
|---|---|
| SWI/SNF BRG1/PBAF Chromatin Remodeling | |
| INO80 Chromatin Remodeling | |
| SRCAP Chromatin Remodeling | |
| TRRAP/TIP60 Chromatin Remodeling | |
| pancreatic cancer pathway |
| Group | Chromatin remodeling |
|---|---|
| DNA replication | |
| signal transduction | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| transcription, DNA-dependent | |
| DNA repair | |
| DNA recombination | |
| histone H2A acetylation | |
| histone H4 acetylation | |
| response to DNA damage stimulus | |
| chromatin modification | |
| chromatin remodeling | |
| regulation of growth | |
| neural retina development | |
| nervous system development | |
| chromatin binding | |
| ATP binding | |
| transcription coactivator activity | |
| chromatin remodeling complex | |
| Ino80 complex | |
| npBAF complex | |
| SWI-SNF complex | |
| NuA4 histone acetyltransferase complex | |
| plasma membrane | |
| nucleus |
| MedScan ID | 86 |
|---|
| Hugo ID | 24124 |
|---|
| Human chromosome position | 3q26.33 |
|---|
| LocusLink ID | 86 |
|---|---|
| 56456 | |
| 361925 |
| Alias | Arp4 |
|---|---|
| ACTL6 | |
| BAF53A | |
| INO80K | |
| ARPN-BETA | |
| actin-like protein 6A | |
| BAF53 | |
| arpNbeta | |
| hArpN beta | |
| INO80 complex subunit K | |
| actin-related protein 4 | |
| BAF complex 53 kDa subunit | |
| BRG1-associated factor 53A | |
| actin-related protein Baf53a | |
| 53 kDa BRG1-associated factor A | |
| C79802 | |
| AI851094 | |
| 2810432C06Rik | |
| actin-like 6 | |
| BRG1/brm-associated factor 53A | |
| RGD1307747 | |
| brm-associated factor 53A | |
| MGC112664 | |
| OTTMUSP00000024516 | |
| BRG1/Brahma-associated factor 53A | |
| MGC5382 | |
| Brahma-associated factor 53A | |
| actin-like 6A | |
| Actl6a | |
| 2810432C06 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 604958 |
|---|
| Unigene ID | Hs.435326 |
|---|---|
| Mm.41077 | |
| Rn.31666 |
| KEGG ID | hsa:86 |
|---|---|
| mmu:56456 | |
| rno:361925 |
| Swiss-Prot Accession | O96019 |
|---|---|
| Q505L1 | |
| Q9Z2N8 | |
| Q4KM87 | |
| Q8C1W3 | |
| Q99M56 | |
| B3KMN1 | |
| D3DNR9 | |
| Q8TAE5 | |
| Q9BVS8 | |
| Q9H0W6 |
| GO ID | 0005524 |
|---|---|
| 0003682 | |
| 0003713 | |
| 0006310 | |
| 0006281 | |
| 0006338 | |
| 0043968 | |
| 0043967 | |
| 0007399 | |
| 0003407 | |
| 0040008 | |
| 0006357 | |
| 0007165 | |
| 0006351 | |
| 0031011 | |
| 0035267 | |
| 0016514 | |
| 0071564 | |
| 0005634 | |
| 0005886 | |
| 0016568 | |
| 0006355 | |
| 0006974 | |
| 0016585 |
| Swiss-Prot ID | ACL6A_MOUSE |
|---|---|
| ACL6A_HUMAN |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00323660 |
|---|---|
| IPI00003627 | |
| IPI00216622 |
| Mouse chromosome position | 3 |
|---|
| Rat chromosome position | 2q25 |
|---|
| Homologene ID | 55811 |
|---|
| MGI ID | 1861453 |
|---|
| RGD ID | 1307747 |
|---|
| Primary Cell Localization | Nucleus |
|---|