| URN | urn:agi-llid:2737 |
|---|---|
| Connectivity | 117 |
| Name | Gli3 |
| Description | GLI family zinc finger 3 |
| Notes | This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq] |
| Pathway | pancreatic cancer pathway |
|---|
| GO Molecular Function | chromatin binding |
|---|---|
| nucleic acid binding | |
| transcription repressor activity | |
| transcription factor activity | |
| beta-catenin binding | |
| transcription repressor binding | |
| DNA binding | |
| histone acetyltransferase binding | |
| histone deacetylase binding | |
| sequence-specific DNA binding | |
| metal ion binding | |
| zinc ion binding |
| GO Cellular Component | intracellular |
|---|---|
| cilium | |
| cytoplasm | |
| cytosol | |
| nucleolus | |
| mediator complex | |
| transcriptional repressor complex | |
| nucleus |
| GO Biological Process | negative regulation of cell proliferation |
|---|---|
| pattern specification process | |
| developmental growth | |
| anatomical structure development | |
| anatomical structure formation involved in morphogenesis | |
| telencephalon development | |
| forebrain development | |
| inner ear development | |
| neural tube development | |
| tube development | |
| pallium development | |
| regulation of cell differentiation | |
| hindgut morphogenesis | |
| embryonic morphogenesis | |
| negative regulation of cell differentiation | |
| mammary gland specification | |
| anterior-posterior pattern formation | |
| proximal-distal pattern formation | |
| dorsal-ventral pattern formation | |
| spinal cord dorsal-ventral patterning | |
| forebrain dorsal-ventral pattern formation | |
| central nervous system development | |
| embryonic digestive tract development | |
| anterior semicircular canal development | |
| lateral semicircular canal development | |
| brain development | |
| kidney development | |
| lung development | |
| heart development | |
| artery development | |
| metanephros development | |
| mammary gland development | |
| camera-type eye development | |
| positive regulation of chondrocyte differentiation | |
| neuron fate commitment | |
| embryonic digestive tract morphogenesis | |
| embryonic digit morphogenesis | |
| branching morphogenesis of a tube | |
| limb morphogenesis | |
| optic nerve morphogenesis | |
| branching involved in ureteric bud morphogenesis | |
| embryonic skeletal system morphogenesis | |
| embryonic limb morphogenesis | |
| camera-type eye morphogenesis | |
| odontogenesis of dentine-containing tooth | |
| in utero embryonic development | |
| axon guidance | |
| negative regulation of Wnt receptor signaling pathway through beta-catenin | |
| regulation of transcription | |
| negative regulation of transcription | |
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| regulation of gene-specific transcription | |
| positive regulation of protein import into nucleus | |
| regulation of apoptosis | |
| transcription | |
| regulation of gene expression | |
| protein processing | |
| smoothened signaling pathway | |
| smoothened signaling pathway involved in dorsal-ventral neural tube patterning | |
| smoothened signaling pathway involved in ventral spinal cord interneuron specification | |
| smoothened signaling pathway involved in spinal cord motor neuron cell fate specification |
| Ariadne Ontology | GLI-like |
|---|---|
| Oncogenes |
| Group | GLI-like |
|---|---|
| Oncogenes | |
| negative regulation of cell proliferation | |
| pattern specification process | |
| developmental growth | |
| anatomical structure development | |
| anatomical structure formation involved in morphogenesis | |
| telencephalon development | |
| forebrain development | |
| inner ear development | |
| neural tube development | |
| tube development | |
| pallium development | |
| regulation of cell differentiation | |
| hindgut morphogenesis | |
| embryonic morphogenesis | |
| negative regulation of cell differentiation | |
| mammary gland specification | |
| anterior-posterior pattern formation | |
| proximal-distal pattern formation | |
| dorsal-ventral pattern formation | |
| spinal cord dorsal-ventral patterning | |
| forebrain dorsal-ventral pattern formation | |
| central nervous system development | |
| embryonic digestive tract development | |
| anterior semicircular canal development | |
| lateral semicircular canal development | |
| brain development | |
| kidney development | |
| lung development | |
| heart development | |
| artery development | |
| metanephros development | |
| mammary gland development | |
| camera-type eye development | |
| positive regulation of chondrocyte differentiation | |
| neuron fate commitment | |
| embryonic digestive tract morphogenesis | |
| embryonic digit morphogenesis | |
| branching morphogenesis of a tube | |
| limb morphogenesis | |
| optic nerve morphogenesis | |
| branching involved in ureteric bud morphogenesis | |
| embryonic skeletal system morphogenesis | |
| embryonic limb morphogenesis | |
| camera-type eye morphogenesis | |
| odontogenesis of dentine-containing tooth | |
| in utero embryonic development | |
| axon guidance | |
| negative regulation of Wnt receptor signaling pathway through beta-catenin | |
| regulation of transcription | |
| negative regulation of transcription | |
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| regulation of gene-specific transcription | |
| positive regulation of protein import into nucleus | |
| regulation of apoptosis | |
| transcription | |
| regulation of gene expression | |
| protein processing | |
| smoothened signaling pathway | |
| smoothened signaling pathway involved in dorsal-ventral neural tube patterning | |
| smoothened signaling pathway involved in ventral spinal cord interneuron specification | |
| smoothened signaling pathway involved in spinal cord motor neuron cell fate specification | |
| chromatin binding | |
| nucleic acid binding | |
| transcription repressor activity | |
| transcription factor activity | |
| beta-catenin binding | |
| transcription repressor binding | |
| DNA binding | |
| histone acetyltransferase binding | |
| histone deacetylase binding | |
| sequence-specific DNA binding | |
| metal ion binding | |
| zinc ion binding | |
| intracellular | |
| cilium | |
| cytoplasm | |
| cytosol | |
| nucleolus | |
| mediator complex | |
| transcriptional repressor complex | |
| nucleus |
| MedScan ID | 2737 |
|---|
| Hugo ID | 4319 |
|---|
| Human chromosome position | 7p13 |
|---|
| LocusLink ID | 2737 |
|---|---|
| 14634 |
| Alias | PHS |
|---|---|
| ACLS | |
| GCPS | |
| PAPA | |
| PAPB | |
| PAP-A | |
| PAPA1 | |
| PPDIV | |
| zinc finger protein GLI3 | |
| oncogene GLI3 | |
| OTTHUMP00000159085 | |
| DNA-binding protein | |
| GLI-Kruppel family member GLI3 | |
| glioma-associated oncogene family zinc finger 3 | |
| Xt | |
| Bph | |
| Pdn | |
| add | |
| AI854843 | |
| AU023367 | |
| extra toes | |
| brachyphalangy | |
| OTTMUSP00000029127 | |
| OTTMUSP00000029128 | |
| polydactyly Nagoya | |
| anterior digit pattern deformity | |
| anterior digit pattern deformity mutant | |
| DNA-binding GLI3 | |
| extra toes mutant | |
| GLI family zinc finger 3 | |
| GLI3 | |
| GLI-Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome) | |
| OTTHUMP00000025248 | |
| PPD IV |
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| OMIM ID | 165240 |
|---|---|
| 200990 | |
| 175700 | |
| 241800 | |
| 146510 | |
| 174200 | |
| 174700 |
| Mouse chromosome position | 13 14.0 cM |
|---|
| GO ID | 0008013 |
|---|---|
| 0003682 | |
| 0035035 | |
| 0042826 | |
| 0046872 | |
| 0043565 | |
| 0003700 | |
| 0016564 | |
| 0008270 | |
| 0048646 | |
| 0060873 | |
| 0009952 | |
| 0060840 | |
| 0007411 | |
| 0001658 | |
| 0048593 | |
| 0048589 | |
| 0048566 | |
| 0042733 | |
| 0048704 | |
| 0021798 | |
| 0007507 | |
| 0007442 | |
| 0001701 | |
| 0048839 | |
| 0060875 | |
| 0035108 | |
| 0030324 | |
| 0030879 | |
| 0001656 | |
| 0090090 | |
| 0045596 | |
| 0008285 | |
| 0000122 | |
| 0021915 | |
| 0048663 | |
| 0042475 | |
| 0021631 | |
| 0021543 | |
| 0007389 | |
| 0032332 | |
| 0010552 | |
| 0042307 | |
| 0045941 | |
| 0045944 | |
| 0016485 | |
| 0009954 | |
| 0042981 | |
| 0060831 | |
| 0021776 | |
| 0021775 | |
| 0021513 | |
| 0035295 | |
| 0005929 | |
| 0005737 | |
| 0005829 | |
| 0005622 | |
| 0016592 | |
| 0005634 | |
| 0017053 | |
| 0003677 | |
| 0003676 | |
| 0048856 | |
| 0007420 | |
| 0048754 | |
| 0043010 | |
| 0007417 | |
| 0009953 | |
| 0048557 | |
| 0030326 | |
| 0048598 | |
| 0030900 | |
| 0001822 | |
| 0060594 | |
| 0016481 | |
| 0045595 | |
| 0010468 | |
| 0032583 | |
| 0045449 | |
| 0007224 | |
| 0021537 | |
| 0006350 | |
| 0048558 | |
| 0005730 | |
| 0070491 |
| Swiss-Prot Accession | P10071 |
|---|---|
| B2RUG4 | |
| Q3TYX7 | |
| Q61602 | |
| Q3UMJ8 | |
| A4D1W1 | |
| O75219 | |
| Q17RW4 | |
| Q75MT0 | |
| Q75MU9 | |
| Q9UDT5 | |
| Q9UJ39 |
| PIR ID | A35927 |
|---|
| Unigene ID | Hs.21509 |
|---|---|
| Mm.5098 |
| KEGG ID | hsa:2737 |
|---|---|
| mmu:14634 |
| Swiss-Prot ID | GLI3_MOUSE |
|---|---|
| GLI3_HUMAN | |
| B2RUG4_MOUSE | |
| Q3TYX7_MOUSE |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00123429 |
|---|---|
| IPI00018889 | |
| IPI00651982 | |
| IPI00857095 |
| Homologene ID | 139 |
|---|
| MGI ID | 95729 |
|---|