| URN | urn:agi-llid:2735 |
|---|---|
| Connectivity | 262 |
| Name | Gli1 |
| Description | GLI family zinc finger 1 |
| Notes | This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
| Pathway | pancreatic cancer pathway |
|---|
| GO Molecular Function | chromatin binding |
|---|---|
| nucleic acid binding | |
| transcription activator activity | |
| DNA binding | |
| microtubule binding | |
| RNA polymerase II transcription factor activity, enhancer binding | |
| metal ion binding | |
| zinc ion binding |
| GO Cellular Component | intracellular |
|---|---|
| cilium | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | positive regulation of cell proliferation |
|---|---|
| multicellular organismal development | |
| ventral midline development | |
| cerebellar cortex morphogenesis | |
| notochord regression | |
| cell differentiation | |
| proximal-distal pattern formation | |
| dorsal-ventral pattern formation | |
| lung development | |
| pituitary gland development | |
| osteoblast differentiation | |
| epidermal cell differentiation | |
| spermatogenesis | |
| signal transduction | |
| regulation of transcription | |
| positive regulation of transcription | |
| positive regulation of DNA replication | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| transcription | |
| regulation of smoothened signaling pathway | |
| smoothened signaling pathway | |
| smoothened signaling pathway involved in regulation of granule cell precursor cell proliferation |
| Ariadne Ontology | GLI-like |
|---|---|
| Oncogenes |
| Group | GLI-like |
|---|---|
| Oncogenes | |
| positive regulation of cell proliferation | |
| multicellular organismal development | |
| ventral midline development | |
| cerebellar cortex morphogenesis | |
| notochord regression | |
| cell differentiation | |
| proximal-distal pattern formation | |
| dorsal-ventral pattern formation | |
| lung development | |
| pituitary gland development | |
| osteoblast differentiation | |
| epidermal cell differentiation | |
| spermatogenesis | |
| signal transduction | |
| regulation of transcription | |
| positive regulation of transcription | |
| positive regulation of DNA replication | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| transcription | |
| regulation of smoothened signaling pathway | |
| smoothened signaling pathway | |
| smoothened signaling pathway involved in regulation of granule cell precursor cell proliferation | |
| chromatin binding | |
| nucleic acid binding | |
| transcription activator activity | |
| DNA binding | |
| microtubule binding | |
| RNA polymerase II transcription factor activity, enhancer binding | |
| metal ion binding | |
| zinc ion binding | |
| intracellular | |
| cilium | |
| cytoplasm | |
| cytosol | |
| nucleus |
| MedScan ID | 2735 |
|---|
| Hugo ID | 4317 |
|---|
| Human chromosome position | 12q13.2-q13.3 |
|---|
| LocusLink ID | 2735 |
|---|---|
| 14632 | |
| 140589 |
| Alias | GLI |
|---|---|
| zinc finger protein GLI1 | |
| oncogene GLI | |
| glioma-associated oncogene family zinc finger 1 | |
| glioma-associated oncogene homolog 1 (zinc finger protein) | |
| Zfp5 | |
| Zfp-5 | |
| AV235269 | |
| zinc finger protein 5 | |
| glioma-associated oncogene homolog | |
| GLI-Kruppel family member GLI1 | |
| GLI family zinc finger 1 | |
| GLI I | |
| GLI1 | |
| GLI-Kruppel family member GLI | |
| Glioma-associated oncogene | |
| glioma-associated oncogene homolog (zinc finger protein) | |
| glioma-associated oncogene homolog 1 | |
| glioma-associated oncogene homolog I | |
| Zinc finger protein GLI I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 165220 |
|---|
| Mouse chromosome position | 10 69.0 cM |
|---|
| GO ID | 0003677 |
|---|---|
| 0003705 | |
| 0003682 | |
| 0046872 | |
| 0008017 | |
| 0016563 | |
| 0008270 | |
| 0021696 | |
| 0009953 | |
| 0009913 | |
| 0030324 | |
| 0007275 | |
| 0060032 | |
| 0001649 | |
| 0021983 | |
| 0045740 | |
| 0008284 | |
| 0045944 | |
| 0009954 | |
| 0008589 | |
| 0021938 | |
| 0007283 | |
| 0007418 | |
| 0005929 | |
| 0005737 | |
| 0005829 | |
| 0005622 | |
| 0005634 | |
| 0003676 | |
| 0030154 | |
| 0045941 | |
| 0045893 | |
| 0045449 | |
| 0007165 | |
| 0007224 | |
| 0006350 |
| Rat chromosome position | 7q22 |
|---|
| Swiss-Prot Accession | B4DNF7 |
|---|---|
| P08151 | |
| P47806 | |
| Q91WY6 | |
| Q9QYK1 | |
| Q8TDN9 |
| PIR ID | S00672 |
|---|
| Unigene ID | Hs.632702 |
|---|---|
| Mm.391450 | |
| Rn.219157 |
| KEGG ID | hsa:2735 |
|---|---|
| mmu:14632 | |
| rno:140589 |
| Swiss-Prot ID | GLI1_MOUSE |
|---|---|
| GLI1_HUMAN | |
| B4DNF7_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| IPI ID | IPI00112331 |
|---|---|
| IPI00027451 | |
| IPI00910721 | |
| IPI00797932 | |
| IPI00831526 | |
| IPI00363444 |
| Homologene ID | 3859 |
|---|
| RGD ID | 621673 |
|---|
| MGI ID | 95727 |
|---|