| URN | urn:agi-llid:208 |
|---|---|
| Connectivity | 237 |
| Name | Akt2 |
| Description | thymoma viral proto-oncogene 2 |
| Notes | may be involved in phosphatidylinositol 3-kinase (PI3-K) mediated signaling [RGD] |
| Pathway | IGF1R -> MEF/MYOD/MYOG signaling |
|---|---|
| EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling | |
| VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling | |
| VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| insulin responsive facilitative sugar transporter mediated glucose transport pathway | |
| type 2 diabetes mellitus pathway | |
| altered insulin responsive facilitative sugar transporter mediated glucose transport pathway | |
| phosphatidylinositol 3-kinase-Akt signaling pathway | |
| pancreatic cancer pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity |
| GO Cellular Component | vesicle |
|---|---|
| soluble fraction | |
| plasma membrane | |
| lamellipodium | |
| cytosol | |
| mitochondrion | |
| insulin-responsive compartment | |
| nucleoplasm | |
| nucleus | |
| microsome |
| GO Biological Process | cellular response to chemical stimulus |
|---|---|
| positive regulation of signal transduction | |
| regulation of JNK cascade | |
| protein kinase B signaling cascade | |
| positive regulation of fatty acid beta-oxidation | |
| negative regulation of RNA splicing | |
| positive regulation of glucose metabolic process | |
| positive regulation of glycogen biosynthetic process | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein amino acid phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of cell migration | |
| negative regulation of apoptosis | |
| negative regulation of caspase activity | |
| protein modification process | |
| protein amino acid phosphorylation | |
| cellular response to hormone stimulus | |
| cellular response to insulin stimulus | |
| insulin receptor signaling pathway | |
| response to osmotic stress | |
| response to muscle activity | |
| response to insulin stimulus | |
| positive regulation of positive chemotaxis | |
| response to nutrient levels | |
| negative regulation of plasma membrane long-chain fatty acid transport | |
| positive regulation of gene expression | |
| positive regulation of sodium ion transport | |
| positive regulation of glucose import |
| Ariadne Ontology | AKT |
|---|---|
| Oncogenes |
| Group | AKT |
|---|---|
| Oncogenes | |
| cellular response to chemical stimulus | |
| positive regulation of signal transduction | |
| regulation of JNK cascade | |
| protein kinase B signaling cascade | |
| positive regulation of fatty acid beta-oxidation | |
| negative regulation of RNA splicing | |
| positive regulation of glucose metabolic process | |
| positive regulation of glycogen biosynthetic process | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of protein amino acid phosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of cell migration | |
| negative regulation of apoptosis | |
| negative regulation of caspase activity | |
| protein modification process | |
| protein amino acid phosphorylation | |
| cellular response to hormone stimulus | |
| cellular response to insulin stimulus | |
| insulin receptor signaling pathway | |
| response to osmotic stress | |
| response to muscle activity | |
| response to insulin stimulus | |
| positive regulation of positive chemotaxis | |
| response to nutrient levels | |
| negative regulation of plasma membrane long-chain fatty acid transport | |
| positive regulation of gene expression | |
| positive regulation of sodium ion transport | |
| positive regulation of glucose import | |
| nucleotide binding | |
| transferase activity | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| vesicle | |
| soluble fraction | |
| plasma membrane | |
| lamellipodium | |
| cytosol | |
| mitochondrion | |
| insulin-responsive compartment | |
| nucleoplasm | |
| nucleus | |
| microsome |
| MedScan ID | 208 |
|---|
| Hugo ID | 392 |
|---|
| Human chromosome position | 19q13.1-q13.2 |
|---|
| LocusLink ID | 208 |
|---|---|
| 11652 | |
| 25233 |
| Alias | PKBB |
|---|---|
| PRKBB | |
| PKBBETA | |
| RAC-BETA | |
| RAC-beta serine/threonine-protein kinase | |
| PKB beta | |
| RAC-PK-beta | |
| protein kinase Akt-2 | |
| protein kinase B beta | |
| rac protein kinase beta | |
| Murine thymoma viral (v-akt) homolog-2 | |
| PKB | |
| AW554154 | |
| MGC14031 | |
| 2410016A19Rik | |
| OTTMUSP00000017783 | |
| OTTMUSP00000017784 | |
| OTTMUSP00000017785 | |
| OTTMUSP00000022681 | |
| protein kinase B, beta | |
| RAC-beta serine/threonine protein kinase | |
| AKT2 kinase | |
| thymoma viral proto-oncogene 2 | |
| RAC protein kinase beta RAC-PK beta | |
| murine thymoma viral (v-akt) oncogene homolog 2 | |
| 2410016A19 | |
| Akt2 | |
| AKTII | |
| Murine thymoma viral (v-akt) homolog II | |
| Murine thymoma viral (v-akt) oncogene homolog II | |
| Protein kinase Akt II | |
| rac kinase | |
| thymoma viral proto-oncogene II | |
| v-akt murine thymoma viral oncogene homolog 2 | |
| v-akt murine thymoma viral oncogene homolog II | |
| RIKEN cDNA 2410016A19 gene |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 164731 |
|---|---|
| 125853 |
| Mouse chromosome position | 7 6.5 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0016301 | |
| 0000166 | |
| 0004674 | |
| 0016740 | |
| 0070887 | |
| 0032870 | |
| 0032869 | |
| 0008286 | |
| 0033119 | |
| 0043066 | |
| 0043154 | |
| 0010748 | |
| 0030335 | |
| 0032000 | |
| 0010628 | |
| 0046326 | |
| 0010907 | |
| 0045725 | |
| 0045429 | |
| 0033138 | |
| 0050927 | |
| 0009967 | |
| 0010765 | |
| 0045944 | |
| 0043491 | |
| 0006464 | |
| 0046328 | |
| 0014850 | |
| 0006970 | |
| 0005829 | |
| 0032593 | |
| 0030027 | |
| 0005792 | |
| 0005739 | |
| 0005634 | |
| 0005886 | |
| 0005625 | |
| 0031982 | |
| 0004672 | |
| 0001934 | |
| 0006468 | |
| 0032868 | |
| 0031667 | |
| 0005654 | |
| 0005515 | |
| 0006006 |
| Rat chromosome position | 1q22 |
|---|
| Swiss-Prot Accession | P31751 |
|---|---|
| Q05BV0 | |
| Q0VAN0 | |
| Q6P4H3 | |
| Q8TBE2 | |
| Q3TY95 | |
| Q60823 | |
| Q8CE74 | |
| P47197 | |
| Q3HSE5 | |
| B2RBD8 | |
| Q0VAN1 | |
| Q68GC0 |
| PIR ID | JC2438 |
|---|---|
| A46288 |
| Unigene ID | Hs.631535 |
|---|---|
| Mm.177194 | |
| Rn.87066 |
| KEGG ID | hsa:208 |
|---|---|
| mmu:11652 | |
| rno:25233 |
| EC Number | 2.7.11.1 |
|---|---|
| 2.7.1.- |
| Swiss-Prot ID | AKT2_RAT |
|---|---|
| AKT2_HUMAN | |
| Q3TY95_MOUSE | |
| AKT2_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00212846 |
|---|---|
| IPI00012870 | |
| IPI00784816 | |
| IPI00440705 | |
| IPI00816059 | |
| IPI00641838 | |
| IPI00790293 | |
| IPI00798192 | |
| IPI00788928 | |
| IPI00797131 | |
| IPI00797722 | |
| IPI00795867 | |
| IPI00794313 | |
| IPI00121335 | |
| IPI00830259 | |
| IPI00831519 | |
| IPI00830488 | |
| IPI00830166 | |
| IPI00830685 | |
| IPI00754038 | |
| IPI00830607 |
| Homologene ID | 48773 |
|---|
| RGD ID | 2082 |
|---|
| MGI ID | 104874 |
|---|