| URN | urn:agi-llid:3676 |
|---|---|
| Total Entities | 0 |
| Connectivity | 414 |
| Name | Itga4 |
| Description | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
| Notes | The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | ITG |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | fibronectin binding |
|---|
| GO Cellular Component | membrane |
|---|---|
| external side of plasma membrane | |
| integrin complex | |
| integral to membrane | |
| plasma membrane | |
| cell surface |
| GO Biological Process | cell adhesion |
|---|---|
| integrin-mediated signaling pathway | |
| B cell differentiation | |
| cell-cell adhesion | |
| leukocyte cell-cell adhesion | |
| heterophilic cell-cell adhesion | |
| chorio-allantoic fusion | |
| cell-matrix adhesion | |
| cell migration | |
| leukocyte migration | |
| regulation of immune response | |
| visceral serous pericardium development | |
| face development | |
| heart development | |
| mesenchyme development | |
| blood vessel remodeling | |
| blood coagulation |
| Pathway | pancreatic cancer pathway |
|---|
| Group | ITG |
|---|---|
| cell adhesion | |
| integrin-mediated signaling pathway | |
| B cell differentiation | |
| cell-cell adhesion | |
| leukocyte cell-cell adhesion | |
| heterophilic cell-cell adhesion | |
| chorio-allantoic fusion | |
| cell-matrix adhesion | |
| cell migration | |
| leukocyte migration | |
| regulation of immune response | |
| visceral serous pericardium development | |
| face development | |
| heart development | |
| mesenchyme development | |
| blood vessel remodeling | |
| blood coagulation | |
| fibronectin binding | |
| membrane | |
| external side of plasma membrane | |
| integrin complex | |
| integral to membrane | |
| plasma membrane | |
| cell surface | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 3676 |
|---|
| Hugo ID | 6140 |
|---|
| Human chromosome position | 2q31.3 |
|---|
| LocusLink ID | 3676 |
|---|---|
| 16401 | |
| 311144 |
| Alias | IA4 |
|---|---|
| CD49D | |
| integrin alpha-4 | |
| 269C wild type | |
| integrin alpha 4 | |
| integrin alpha-IV | |
| VLA-4 subunit alpha | |
| integrin alpha-4 subunit | |
| CD49 antigen-like family member D | |
| antigen CD49D, alpha-4 subunit of VLA-4 receptor | |
| very late activation protein 4 receptor, alpha 4 subunit | |
| RP23-335P15.1 | |
| LPAM subunit alpha | |
| VLA-4 receptor, alpha 4 subunit | |
| lymphocyte Peyer patch adhesion molecules subunit alpha | |
| Itga4 | |
| MGC90518 | |
| OTTMUSP00000014305 | |
| VLA-4 receptor alpha-4 subunit | |
| integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | |
| VLA4-alpha4 | |
| VLA-4 alpha | |
| alpha 4 integrin | |
| alpha iv integrin | |
| alpha-4 subunit of VLA-4 receptor | |
| alpha-4 subunit of VLA-4 receptors | |
| antigen CD49D | |
| integrin alpha 4 (Cd49d) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 192975 |
|---|
| Unigene ID | Hs.440955 |
|---|---|
| Mm.31903 | |
| Rn.12704 |
| KEGG ID | hsa:3676 |
|---|---|
| mmu:16401 | |
| rno:311144 |
| Swiss-Prot Accession | P13612 |
|---|---|
| Q00651 | |
| Q792F9 | |
| Q8BQ25 | |
| D3DPG4 |
| GO ID | 0001968 |
|---|---|
| 0030183 | |
| 0007596 | |
| 0001974 | |
| 0060710 | |
| 0060324 | |
| 0007507 | |
| 0007157 | |
| 0007229 | |
| 0007159 | |
| 0050900 | |
| 0050776 | |
| 0009986 | |
| 0009897 | |
| 0008305 | |
| 0005886 | |
| 0007155 | |
| 0016477 | |
| 0016337 | |
| 0007160 | |
| 0060485 | |
| 0061032 | |
| 0016021 | |
| 0016020 |
| PIR ID | A41131 |
|---|---|
| S06046 |
| Swiss-Prot ID | ITA4_MOUSE |
|---|---|
| ITA4_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00121334 |
|---|---|
| IPI00009803 |
| Mouse chromosome position | 2 46.0 cM |
|---|
| Rat chromosome position | 3q24 |
|---|
| Homologene ID | 37364 |
|---|
| MGI ID | 96603 |
|---|
| RGD ID | 1593249 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|