| URN | urn:agi-llid:7040 |
|---|---|
| Connectivity | 3974 |
| Name | Tgfb1 |
| Description | transforming growth factor, beta 1 |
| Notes | binds the TGFbeta receptor; plays a role in regulation of cell growth and proliferation; induces synthesis of extracellular matrix proteins and may play a role in fibrosis [RGD] |
| Pathway | TGFBR -> AP-1 signaling |
|---|---|
| TGFBR -> ATF/GADD/MAX/TP53 signaling | |
| TGFBR -> CREB/ELK-SRF signaling | |
| TGFBR -> MEF/MYOD/MYOG signaling | |
| TGFBR -> SMAD1/5/9 signaling | |
| TGFBR/BMPR -> SMAD2/3 signaling | |
| transforming growth factor-beta Smad dependent signaling pathway | |
| colorectal cancer pathway | |
| altered transforming growth factor-beta Smad dependent signaling pathway |
| GO Molecular Function | transcription activator activity |
|---|---|
| protein N-terminus binding | |
| protein homodimerization activity | |
| growth factor activity | |
| protein heterodimerization activity | |
| transforming growth factor beta receptor binding | |
| type II transforming growth factor beta receptor binding |
| GO Cellular Component | extracellular region |
|---|---|
| cell surface | |
| extracellular space | |
| extracellular matrix | |
| neuronal cell body | |
| cytoplasm | |
| Golgi lumen | |
| platelet alpha granule lumen | |
| stored secretory granule | |
| nucleus | |
| axon | |
| proteinaceous extracellular matrix |
| GO Biological Process | growth |
|---|---|
| cell proliferation | |
| cell death | |
| negative regulation of cell proliferation | |
| regulation of cell proliferation | |
| positive regulation of cell proliferation | |
| cell growth | |
| embryonic development | |
| aging | |
| morphogenesis of a branching structure | |
| female pregnancy | |
| defense response to fungus, incompatible interaction | |
| evasion of host defenses by virus | |
| positive regulation of odontogenesis | |
| positive regulation of branching involved in ureteric bud morphogenesis | |
| inner ear development | |
| digestive tract development | |
| organ morphogenesis | |
| negative regulation of ossification | |
| ossification involved in bone remodeling | |
| mammary gland branching involved in thelarche | |
| positive regulation of bone mineralization | |
| branch elongation involved in mammary gland duct branching | |
| endoderm development | |
| skeletal system development | |
| ureteric bud development | |
| lung development | |
| negative regulation of neuroblast proliferation | |
| lymph node development | |
| mammary gland development | |
| regulation of striated muscle tissue development | |
| skeletal muscle tissue development | |
| positive regulation of smooth muscle cell differentiation | |
| chondrocyte differentiation | |
| lens fiber cell differentiation | |
| hemopoietic progenitor cell differentiation | |
| epithelial to mesenchymal transition | |
| positive regulation of epithelial to mesenchymal transition | |
| negative regulation of fat cell differentiation | |
| macrophage derived foam cell differentiation | |
| T cell differentiation | |
| myeloid dendritic cell differentiation | |
| regulatory T cell differentiation | |
| salivary gland morphogenesis | |
| frontal suture morphogenesis | |
| organ regeneration | |
| regulation of branching involved in mammary gland duct morphogenesis | |
| positive regulation of isotype switching to IgA isotypes | |
| connective tissue replacement during inflammatory response | |
| positive regulation of interleukin-17 production | |
| positive regulation of collagen biosynthetic process | |
| negative regulation of cell cycle | |
| regulation of cell growth | |
| germ cell migration | |
| cell-cell junction organization | |
| cell cycle arrest | |
| negative regulation of cell growth | |
| positive regulation of protein secretion | |
| positive regulation of cell division | |
| positive regulation of exit from mitosis | |
| negative regulation of mitotic cell cycle | |
| G1-S transition checkpoint | |
| positive regulation of MAP kinase activity | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of SMAD protein nuclear translocation | |
| positive regulation of pathway-restricted SMAD protein phosphorylation | |
| regulation of cell migration | |
| positive regulation of cellular protein metabolic process | |
| negative regulation of transcription | |
| negative regulation of DNA replication | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of protein amino acid phosphorylation | |
| positive regulation of transcription | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of gene-specific transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of protein amino acid phosphorylation | |
| positive regulation of protein amino acid dephosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of peptidyl-threonine phosphorylation | |
| positive regulation of histone acetylation | |
| positive regulation of histone deacetylation | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of phosphoinositide 3-kinase activity | |
| negative regulation of epithelial cell proliferation | |
| positive regulation of epithelial cell proliferation | |
| negative regulation of T cell proliferation | |
| positive regulation of fibroblast migration | |
| positive regulation of blood vessel endothelial cell migration | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| negative regulation of release of sequestered calcium ion into cytosol | |
| negative regulation of cell-cell adhesion | |
| negative regulation of phagocytosis | |
| negative regulation of T cell activation | |
| negative regulation of blood vessel endothelial cell migration | |
| regulation of protein import into nucleus | |
| T cell activation | |
| phosphate metabolic process | |
| receptor catabolic process | |
| ATP biosynthetic process | |
| protein amino acid phosphorylation | |
| pathway-restricted SMAD protein phosphorylation | |
| cellular calcium ion homeostasis | |
| SMAD protein complex assembly | |
| myelination | |
| cellular response to growth factor stimulus | |
| cellular response to dexamethasone stimulus | |
| negative regulation of immune response | |
| tolerance induction to self antigen | |
| T cell homeostasis | |
| mononuclear cell proliferation | |
| response to radiation | |
| response to organic substance | |
| response to drug | |
| response to hypoxia | |
| defense response | |
| response to wounding | |
| positive regulation of chemotaxis | |
| response to organic cyclic substance | |
| response to protein stimulus | |
| response to cholesterol | |
| response to progesterone stimulus | |
| response to estradiol stimulus | |
| response to glucose stimulus | |
| response to vitamin D | |
| inflammatory response | |
| wound healing | |
| response to laminar fluid shear stress | |
| regulation of transforming growth factor beta receptor signaling pathway | |
| positive regulation of gene expression | |
| regulation of sodium ion transport | |
| SMAD protein nuclear translocation | |
| protein export from nucleus | |
| transforming growth factor beta receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| regulation of binding | |
| regulation of DNA binding |
| Ariadne Ontology | TGF family |
|---|
| Group | TGF family |
|---|---|
| extracellular region | |
| growth | |
| cell proliferation | |
| cell death | |
| negative regulation of cell proliferation | |
| regulation of cell proliferation | |
| positive regulation of cell proliferation | |
| cell growth | |
| embryonic development | |
| aging | |
| morphogenesis of a branching structure | |
| female pregnancy | |
| defense response to fungus, incompatible interaction | |
| evasion of host defenses by virus | |
| positive regulation of odontogenesis | |
| positive regulation of branching involved in ureteric bud morphogenesis | |
| inner ear development | |
| digestive tract development | |
| organ morphogenesis | |
| negative regulation of ossification | |
| ossification involved in bone remodeling | |
| mammary gland branching involved in thelarche | |
| positive regulation of bone mineralization | |
| branch elongation involved in mammary gland duct branching | |
| endoderm development | |
| skeletal system development | |
| ureteric bud development | |
| lung development | |
| negative regulation of neuroblast proliferation | |
| lymph node development | |
| mammary gland development | |
| regulation of striated muscle tissue development | |
| skeletal muscle tissue development | |
| positive regulation of smooth muscle cell differentiation | |
| chondrocyte differentiation | |
| lens fiber cell differentiation | |
| hemopoietic progenitor cell differentiation | |
| epithelial to mesenchymal transition | |
| positive regulation of epithelial to mesenchymal transition | |
| negative regulation of fat cell differentiation | |
| macrophage derived foam cell differentiation | |
| T cell differentiation | |
| myeloid dendritic cell differentiation | |
| regulatory T cell differentiation | |
| salivary gland morphogenesis | |
| frontal suture morphogenesis | |
| organ regeneration | |
| regulation of branching involved in mammary gland duct morphogenesis | |
| positive regulation of isotype switching to IgA isotypes | |
| connective tissue replacement during inflammatory response | |
| positive regulation of interleukin-17 production | |
| positive regulation of collagen biosynthetic process | |
| negative regulation of cell cycle | |
| regulation of cell growth | |
| germ cell migration | |
| cell-cell junction organization | |
| cell cycle arrest | |
| negative regulation of cell growth | |
| positive regulation of protein secretion | |
| positive regulation of cell division | |
| positive regulation of exit from mitosis | |
| negative regulation of mitotic cell cycle | |
| G1-S transition checkpoint | |
| positive regulation of MAP kinase activity | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of SMAD protein nuclear translocation | |
| positive regulation of pathway-restricted SMAD protein phosphorylation | |
| regulation of cell migration | |
| positive regulation of cellular protein metabolic process | |
| negative regulation of transcription | |
| negative regulation of DNA replication | |
| negative regulation of transcription from RNA polymerase II promoter | |
| negative regulation of protein amino acid phosphorylation | |
| positive regulation of transcription | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of gene-specific transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of gene-specific transcription from RNA polymerase II promoter | |
| positive regulation of protein amino acid phosphorylation | |
| positive regulation of protein amino acid dephosphorylation | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of peptidyl-threonine phosphorylation | |
| positive regulation of histone acetylation | |
| positive regulation of histone deacetylation | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of phosphoinositide 3-kinase activity | |
| negative regulation of epithelial cell proliferation | |
| positive regulation of epithelial cell proliferation | |
| negative regulation of T cell proliferation | |
| positive regulation of fibroblast migration | |
| positive regulation of blood vessel endothelial cell migration | |
| positive regulation of apoptosis | |
| induction of apoptosis | |
| negative regulation of release of sequestered calcium ion into cytosol | |
| negative regulation of cell-cell adhesion | |
| negative regulation of phagocytosis | |
| negative regulation of T cell activation | |
| negative regulation of blood vessel endothelial cell migration | |
| regulation of protein import into nucleus | |
| T cell activation | |
| phosphate metabolic process | |
| receptor catabolic process | |
| ATP biosynthetic process | |
| protein amino acid phosphorylation | |
| pathway-restricted SMAD protein phosphorylation | |
| cellular calcium ion homeostasis | |
| SMAD protein complex assembly | |
| myelination | |
| cellular response to growth factor stimulus | |
| cellular response to dexamethasone stimulus | |
| negative regulation of immune response | |
| tolerance induction to self antigen | |
| T cell homeostasis | |
| mononuclear cell proliferation | |
| response to radiation | |
| response to organic substance | |
| response to drug | |
| response to hypoxia | |
| defense response | |
| response to wounding | |
| positive regulation of chemotaxis | |
| response to organic cyclic substance | |
| response to protein stimulus | |
| response to cholesterol | |
| response to progesterone stimulus | |
| response to estradiol stimulus | |
| response to glucose stimulus | |
| response to vitamin D | |
| inflammatory response | |
| wound healing | |
| response to laminar fluid shear stress | |
| regulation of transforming growth factor beta receptor signaling pathway | |
| positive regulation of gene expression | |
| regulation of sodium ion transport | |
| SMAD protein nuclear translocation | |
| protein export from nucleus | |
| transforming growth factor beta receptor signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| regulation of binding | |
| regulation of DNA binding | |
| transcription activator activity | |
| protein N-terminus binding | |
| protein homodimerization activity | |
| growth factor activity | |
| protein heterodimerization activity | |
| transforming growth factor beta receptor binding | |
| type II transforming growth factor beta receptor binding | |
| cell surface | |
| extracellular space | |
| extracellular matrix | |
| neuronal cell body | |
| cytoplasm | |
| Golgi lumen | |
| platelet alpha granule lumen | |
| stored secretory granule | |
| nucleus | |
| axon | |
| proteinaceous extracellular matrix |
| MedScan ID | 7040 |
|---|
| Hugo ID | 11766 |
|---|
| Human chromosome position | 19q13.2 |
|---|
| LocusLink ID | 7040 |
|---|---|
| 21803 | |
| 59086 | |
| 43846 |
| Alias | CED |
|---|---|
| LAP | |
| DPD1 | |
| TGFB | |
| TGFbeta | |
| transforming growth factor beta-1 | |
| TGF-beta-1 | |
| TGF-beta 1 protein | |
| latency-associated peptide | |
| Tgfb-1 | |
| TGFbeta1 | |
| TGF-beta1 | |
| TGF-beta 1 | |
| regulatory protein | |
| transforming growth factor-beta 1 | |
| transforming growth factor, beta-1 | |
| beta 1 transforming growth factor | |
| Camurati-Engelmann disease gene | |
| Camurati-Engelmann disease protein | |
| diaphyseal dysplasia 1, progressive | |
| DPD I | |
| TGF beta | |
| TGF eta | |
| TGF1_HUMAN | |
| TGF1_RAT | |
| Tgfb I | |
| Tgfb1 | |
| TGF-beta I | |
| Transforming growth factor beta 1 | |
| transforming growth factor, beta | |
| transforming growth factor, beta 1 | |
| Transforming growth factor beta 1 precursor | |
| transforming growth factor, beta 1 (Camurati-Engelmann disease) | |
| diaphyseal dysplasia 1, progressive (Camurati-Engelmann disease) | |
| Camurati-Engelmann disease |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 190180 |
|---|---|
| 131300 | |
| 219700 |
| Mouse chromosome position | 7 6.5 cM |
|---|
| GO ID | 0008083 |
|---|---|
| 0047485 | |
| 0046982 | |
| 0042803 | |
| 0016563 | |
| 0005114 | |
| 0006754 | |
| 0031575 | |
| 0007183 | |
| 0007184 | |
| 0043029 | |
| 0007568 | |
| 0060751 | |
| 0007050 | |
| 0008219 | |
| 0045216 | |
| 0006874 | |
| 0071549 | |
| 0002062 | |
| 0002248 | |
| 0009817 | |
| 0048565 | |
| 0009790 | |
| 0007492 | |
| 0007173 | |
| 0019049 | |
| 0007565 | |
| 0060364 | |
| 0008354 | |
| 0002244 | |
| 0006917 | |
| 0006954 | |
| 0048839 | |
| 0070306 | |
| 0048535 | |
| 0010742 | |
| 0060744 | |
| 0030879 | |
| 0032943 | |
| 0001763 | |
| 0042552 | |
| 0043011 | |
| 0008156 | |
| 0042130 | |
| 0043537 | |
| 0045786 | |
| 0030308 | |
| 0008285 | |
| 0022408 | |
| 0050680 | |
| 0045599 | |
| 0050777 | |
| 0045930 | |
| 0007406 | |
| 0030279 | |
| 0050765 | |
| 0001933 | |
| 0051280 | |
| 0016481 | |
| 0000122 | |
| 0031100 | |
| 0043932 | |
| 0060389 | |
| 0006796 | |
| 0043406 | |
| 0051092 | |
| 0060391 | |
| 0043536 | |
| 0030501 | |
| 0090190 | |
| 0051781 | |
| 0008284 | |
| 0032270 | |
| 0050921 | |
| 0032967 | |
| 0050679 | |
| 0010718 | |
| 0031536 | |
| 0010763 | |
| 0010628 | |
| 0043193 | |
| 0010552 | |
| 0035066 | |
| 0031065 | |
| 0032740 | |
| 0048298 | |
| 0010862 | |
| 0033138 | |
| 0010800 | |
| 0043552 | |
| 0035307 | |
| 0001934 | |
| 0051897 | |
| 0050714 | |
| 0045941 | |
| 0045893 | |
| 0006468 | |
| 0006611 | |
| 0032801 | |
| 0051101 | |
| 0051098 | |
| 0060762 | |
| 0030334 | |
| 0042306 | |
| 0016202 | |
| 0017015 | |
| 0045066 | |
| 0070723 | |
| 0042493 | |
| 0032355 | |
| 0009749 | |
| 0001666 | |
| 0034616 | |
| 0014070 | |
| 0032570 | |
| 0051789 | |
| 0009314 | |
| 0033280 | |
| 0009611 | |
| 0007435 | |
| 0002513 | |
| 0007179 | |
| 0001657 | |
| 0042060 | |
| 0005796 | |
| 0030424 | |
| 0009986 | |
| 0005737 | |
| 0005576 | |
| 0005615 | |
| 0043025 | |
| 0005634 | |
| 0031093 | |
| 0005578 | |
| 0030141 | |
| 0005160 | |
| 0042110 | |
| 0030217 | |
| 0016049 | |
| 0008283 | |
| 0071363 | |
| 0006952 | |
| 0001837 | |
| 0040007 | |
| 0050868 | |
| 0009887 | |
| 0043065 | |
| 0042482 | |
| 0051152 | |
| 0045944 | |
| 0042127 | |
| 0002028 | |
| 0010033 | |
| 0007519 | |
| 0001501 | |
| 0031012 | |
| 0030324 | |
| 0001558 | |
| 0042476 | |
| 0045595 | |
| 0005515 | |
| 0006916 | |
| 0000074 | |
| 0007267 |
| Rat chromosome position | 1q22 |
|---|
| Swiss-Prot Accession | P01137 |
|---|---|
| Q49IK8 | |
| Q49IL8 | |
| Q5PY19 | |
| Q671U8 | |
| Q671V1 | |
| Q7Z487 | |
| Q7Z488 | |
| Q86YU2 | |
| P04202 | |
| Q3UNK5 | |
| P17246 | |
| Q9R231 | |
| Q53YM8 | |
| A8K792 | |
| Q9UCG4 |
| PIR ID | S10219 |
|---|---|
| A27513 | |
| A01396 |
| Unigene ID | Hs.645227 |
|---|---|
| Mm.248380 | |
| Rn.40136 | |
| Hs.155218 | |
| Hs.1103 |
| KEGG ID | hsa:7040 |
|---|---|
| mmu:21803 | |
| rno:59086 |
| Swiss-Prot ID | TGFB1_RAT |
|---|---|
| TGFB1_HUMAN | |
| TGFB1_MOUSE | |
| Q3UNK5_MOUSE |
| Cell Localization | Secreted |
|---|---|
| extracellular space | |
| extracellular matrix | |
| Extracellular |
| IPI ID | IPI00214538 |
|---|---|
| IPI00000075 | |
| IPI00114457 |
| Homologene ID | 540 |
|---|
| RGD ID | 69051 |
|---|
| MGI ID | 98725 |
|---|
| Source | Curated |
|---|
| KEGG pathway | Cell cycle |
|---|---|
| MAPK signaling pathway | |
| TGF-beta signaling pathway |