| URN | urn:agi-llid:64750 |
|---|---|
| Total Entities | 0 |
| Connectivity | 283 |
| Name | SMURF2 |
| Description | SMAD specific E3 ubiquitin protein ligase 2 (predicted) |
| GO Molecular Function | ligase activity |
|---|---|
| ubiquitin-protein ligase activity | |
| SMAD binding | |
| transforming growth factor beta receptor binding |
| GO Cellular Component | membrane |
|---|---|
| membrane raft | |
| nucleoplasm | |
| ubiquitin ligase complex | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | negative regulation of transforming growth factor beta receptor signaling pathway |
|---|---|
| regulation of transforming growth factor beta receptor signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| ubiquitin-dependent SMAD protein catabolic process | |
| BMP signaling pathway | |
| negative regulation of transcription, DNA-templated | |
| negative regulation of transcription from RNA polymerase II promoter | |
| transcription, DNA-templated | |
| transcription initiation from RNA polymerase II promoter | |
| protein ubiquitination | |
| protein ubiquitination involved in ubiquitin-dependent protein catabolic process | |
| ubiquitin-dependent protein catabolic process | |
| gene expression |
| Pathway | Basal Breast Cancer |
|---|---|
| Ovarian Cancer Overview | |
| Impaired TGFB2 Signaling in Osteoarthritis | |
| Proteins Involved in Pathogenesis of Osteoarthritis | |
| Osteoarthritis Overview | |
| ActivinR -> SMAD2/3 signaling | |
| TGFBR/BMPR -> SMAD2/3 signaling | |
| BMP7-ACVR2 Expression Targets | |
| INHBA-ACVR2/ACVR1 Expression Targets | |
| MSTN-ACVR2/ACVR1 Expression Targets | |
| TGFB2-TGFBR1 Expression Targets | |
| TGFB3-TGFBR1 Expression Targets | |
| TGFB1-TGFBR1 Expression Targets | |
| TGFB1-TGFBR1/AP-1 Expression Targets | |
| transforming growth factor-beta Smad dependent signaling pathway | |
| transforming growth factor-beta Smad dependent signaling pathway | |
| altered transforming growth factor-beta Smad dependent signaling pathway | |
| transforming growth factor-beta Smad dependent signaling pathway |
| Group | Ubiquitin-dependent protein degradation |
|---|---|
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| regulation of transforming growth factor beta receptor signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| ubiquitin-dependent SMAD protein catabolic process | |
| BMP signaling pathway | |
| negative regulation of transcription, DNA-templated | |
| negative regulation of transcription from RNA polymerase II promoter | |
| ligase activity | |
| ubiquitin-protein ligase activity | |
| transcription, DNA-templated | |
| transcription initiation from RNA polymerase II promoter | |
| protein ubiquitination | |
| protein ubiquitination involved in ubiquitin-dependent protein catabolic process | |
| ubiquitin-dependent protein catabolic process | |
| gene expression | |
| SMAD binding | |
| transforming growth factor beta receptor binding | |
| membrane | |
| membrane raft | |
| nucleoplasm | |
| ubiquitin ligase complex | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| nucleus |
| Source | Curated |
|---|
| LocusLink ID | 64750 |
|---|---|
| 66313 | |
| 303614 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Cell membrane | |
| Membrane raft |
| GO ID | 0046332 |
|---|---|
| 0005160 | |
| 0004842 | |
| 0030509 | |
| 0010467 | |
| 0000122 | |
| 0045892 | |
| 0030512 | |
| 0042787 | |
| 0017015 | |
| 0006367 | |
| 0006351 | |
| 0007179 | |
| 0030579 | |
| 0006511 | |
| 0005737 | |
| 0005829 | |
| 0045121 | |
| 0005654 | |
| 0005634 | |
| 0005886 | |
| 0000151 | |
| 0016874 | |
| 0016567 | |
| 0016020 | |
| 0042802 | |
| 0016481 | |
| 0006464 | |
| 0006512 | |
| 0005622 | |
| 0005515 |
| Alias | E3 ubiquitin-protein ligase SMURF2 |
|---|---|
| hSMURF2 | |
| E3 ubiquitin ligase SMURF2 | |
| SMAD ubiquitination regulatory factor 2 | |
| SMAD-specific E3 ubiquitin-protein ligase 2 | |
| AI558114 | |
| AI649275 | |
| 2810411E22Rik | |
| RP23-170A23.3 | |
| RGD1310067 | |
| SMURF2 | |
| smad specific e3 ubiquitin protein ligase 2 | |
| OTTMUSP00000003747 | |
| MGC138150 | |
| DKFZp686F0270 | |
| 2810411E22 | |
| smad specific e3 ubiquitin protein ligase II | |
| novel protein similar to human E3 ubiquitin ligase SMURF2 | |
| SMURF2s | |
| RIKEN cDNA 2810411E22 gene | |
| expressed sequence AI558114 | |
| SMAD specific E3 ubiquitin protein ligase 2 (predicted) |
| Mouse chromosome position | 11 |
|---|---|
| 11 E1 |
| OMIM ID | 605532 |
|---|
| Rat chromosome position | 10q32.1 |
|---|
| Hugo ID | 16809 |
|---|
| Human chromosome position | 17q22-q23 |
|---|
| Swiss-Prot Accession | Q96DE7 |
|---|---|
| Q9HAU4 | |
| A2A5Z6 | |
| Q9CSE3 | |
| Q52LL1 | |
| Q9H260 | |
| A2A5Z7 | |
| Q5IRE6 |
| Unigene ID | Hs.515011 |
|---|---|
| Mm.340955 | |
| Rn.92843 | |
| Hs.705442 | |
| Mm.392272 |
| KEGG ID | hsa:64750 |
|---|---|
| mmu:66313 | |
| rno:303614 |
| Swiss-Prot ID | SMUF2_HUMAN |
|---|---|
| SMUF2_MOUSE |
| EC Number | 6.3.2.- |
|---|
| Ensembl ID | ENSMUSG00000018363 |
|---|---|
| ENSMUSP00000099356 | |
| ENSMUST00000103067 | |
| ENSRNOG00000014623 | |
| ENSRNOP00000019781 | |
| ENSRNOT00000019781 |
| Homologene ID | 41490 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1913563 |
|---|
| RGD ID | 1310067 |
|---|
| MedScan ID | 64750 |
|---|