| URN | urn:agi-llid:7049 |
|---|---|
| Total Entities | 0 |
| Connectivity | 292 |
| Name | TGFBR3 |
| Description | transforming growth factor, beta receptor III |
| Notes | binds TGF-beta; may regulate TGF-beta receptor type II expression or ligand-binding activity [RGD] |
| GO Molecular Function | coreceptor activity |
|---|---|
| transforming growth factor beta-activated receptor activity | |
| transforming growth factor beta receptor activity, type III | |
| SMAD binding | |
| activin binding | |
| transforming growth factor beta receptor binding | |
| type II transforming growth factor beta receptor binding | |
| transforming growth factor beta binding | |
| fibroblast growth factor binding | |
| PDZ domain binding | |
| glycosaminoglycan binding | |
| heparin binding |
| GO Cellular Component | extracellular matrix |
|---|---|
| membrane | |
| extracellular region | |
| integral component of membrane | |
| inhibin-betaglycan-ActRII complex | |
| external side of plasma membrane | |
| integral component of plasma membrane | |
| cell surface | |
| plasma membrane | |
| cytoplasm | |
| endoplasmic reticulum | |
| proteinaceous extracellular matrix | |
| extracellular space |
| GO Biological Process | immune response |
|---|---|
| definitive erythrocyte differentiation | |
| definitive hemopoiesis | |
| regulation of blood vessel size | |
| embryo development | |
| blood vessel development | |
| coronary vasculature development | |
| coronary vasculature morphogenesis | |
| vasculogenesis involved in coronary vascular morphogenesis | |
| liver development | |
| organ regeneration | |
| heart morphogenesis | |
| cardiac epithelial to mesenchymal transition | |
| heart trabecula formation | |
| ventricular cardiac muscle tissue morphogenesis | |
| cardiac muscle cell proliferation | |
| visceral serous pericardium development | |
| epithelial to mesenchymal transition | |
| negative regulation of epithelial to mesenchymal transition | |
| epicardial cell to mesenchymal cell transition | |
| in utero embryonic development | |
| blastocyst development | |
| negative regulation of epithelial cell migration | |
| cell growth | |
| signal transduction | |
| intracellular signal transduction | |
| positive regulation of transforming growth factor beta receptor signaling pathway | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| BMP signaling pathway | |
| pathway-restricted SMAD protein phosphorylation | |
| transforming growth factor beta receptor complex assembly | |
| negative regulation of cellular component movement | |
| cell migration | |
| negative regulation of epithelial cell proliferation | |
| response to prostaglandin E | |
| response to follicle-stimulating hormone | |
| response to luteinizing hormone | |
| response to hypoxia | |
| positive regulation of NF-kappaB transcription factor activity | |
| palate development | |
| protein phosphorylation | |
| protein complex assembly | |
| regulation of protein binding |
| Pathway | Impairment of BMP and TGF-beta Signaling in Familial and Idiopathic Pulmonary Arterial Hypertension |
|---|---|
| transforming growth factor-beta Smad dependent signaling pathway | |
| transforming growth factor-beta Smad dependent signaling pathway | |
| altered transforming growth factor-beta Smad dependent signaling pathway | |
| transforming growth factor-beta Smad dependent signaling pathway |
| Group | TGFBR |
|---|---|
| immune response | |
| definitive erythrocyte differentiation | |
| definitive hemopoiesis | |
| regulation of blood vessel size | |
| embryo development | |
| blood vessel development | |
| coronary vasculature development | |
| coronary vasculature morphogenesis | |
| vasculogenesis involved in coronary vascular morphogenesis | |
| liver development | |
| organ regeneration | |
| heart morphogenesis | |
| cardiac epithelial to mesenchymal transition | |
| heart trabecula formation | |
| ventricular cardiac muscle tissue morphogenesis | |
| cardiac muscle cell proliferation | |
| visceral serous pericardium development | |
| epithelial to mesenchymal transition | |
| negative regulation of epithelial to mesenchymal transition | |
| epicardial cell to mesenchymal cell transition | |
| in utero embryonic development | |
| blastocyst development | |
| negative regulation of epithelial cell migration | |
| cell growth | |
| signal transduction | |
| intracellular signal transduction | |
| coreceptor activity | |
| transforming growth factor beta-activated receptor activity | |
| transforming growth factor beta receptor activity, type III | |
| positive regulation of transforming growth factor beta receptor signaling pathway | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| BMP signaling pathway | |
| pathway-restricted SMAD protein phosphorylation | |
| transforming growth factor beta receptor complex assembly | |
| negative regulation of cellular component movement | |
| cell migration | |
| negative regulation of epithelial cell proliferation | |
| response to prostaglandin E | |
| response to follicle-stimulating hormone | |
| response to luteinizing hormone | |
| response to hypoxia | |
| positive regulation of NF-kappaB transcription factor activity | |
| palate development | |
| protein phosphorylation | |
| protein complex assembly | |
| regulation of protein binding | |
| SMAD binding | |
| activin binding | |
| transforming growth factor beta receptor binding | |
| type II transforming growth factor beta receptor binding | |
| transforming growth factor beta binding | |
| fibroblast growth factor binding | |
| PDZ domain binding | |
| glycosaminoglycan binding | |
| heparin binding | |
| extracellular matrix | |
| membrane | |
| extracellular region | |
| integral component of membrane | |
| inhibin-betaglycan-ActRII complex | |
| external side of plasma membrane | |
| integral component of plasma membrane | |
| cell surface | |
| plasma membrane | |
| cytoplasm | |
| endoplasmic reticulum | |
| proteinaceous extracellular matrix | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|
| LocusLink ID | 7049 |
|---|---|
| 21814 | |
| 29610 |
| Cell Localization | Plasma membrane |
|---|---|
| Cell membrane | |
| Secreted | |
| Extracellular space | |
| Extracellular matrix |
| GO ID | 0030165 |
|---|---|
| 0046332 | |
| 0048185 | |
| 0015026 | |
| 0017134 | |
| 0005539 | |
| 0008201 | |
| 0050431 | |
| 0070123 | |
| 0005160 | |
| 0005024 | |
| 0005114 | |
| 0030509 | |
| 0001824 | |
| 0001568 | |
| 0060317 | |
| 0060038 | |
| 0016049 | |
| 0016477 | |
| 0060318 | |
| 0060216 | |
| 0001837 | |
| 0003007 | |
| 0060347 | |
| 0006955 | |
| 0035556 | |
| 0001889 | |
| 0051271 | |
| 0010633 | |
| 0050680 | |
| 0010719 | |
| 0030512 | |
| 0031100 | |
| 0060021 | |
| 0060389 | |
| 0051092 | |
| 0030511 | |
| 0043393 | |
| 0032354 | |
| 0001666 | |
| 0034699 | |
| 0034695 | |
| 0007181 | |
| 0007179 | |
| 0055010 | |
| 0009986 | |
| 0005783 | |
| 0009897 | |
| 0005615 | |
| 0034673 | |
| 0005887 | |
| 0005578 | |
| 0060976 | |
| 0060977 | |
| 0009790 | |
| 0003347 | |
| 0001701 | |
| 0006461 | |
| 0006468 | |
| 0050880 | |
| 0060979 | |
| 0061032 | |
| 0005737 | |
| 0005576 | |
| 0016021 | |
| 0016020 | |
| 0005886 | |
| 0007165 | |
| 0031012 | |
| 0004872 | |
| 0007275 | |
| 0048603 | |
| 0005515 | |
| 0042118 | |
| 0007507 |
| Alias | BGCAN |
|---|---|
| betaglycan | |
| transforming growth factor beta receptor type 3 | |
| TGFR-3 | |
| betaglycan proteoglycan | |
| TGF-beta receptor type 3 | |
| TGF-beta receptor type III | |
| TBRIII | |
| AU015626 | |
| AW215636 | |
| 1110036H20Rik | |
| transforming growth factor, beta receptor 3 | |
| TGR3_HUMAN | |
| Tgfbr3 | |
| TGFR III | |
| TGR3 | |
| TGR3_RAT | |
| Transforming growth factor beta 3 precursor receptors | |
| transforming growth factor beta-3 receptor | |
| transforming growth factor beta-3 receptor precursors | |
| RIKEN cDNA 1110036H20 gene | |
| OTTHUMP00000011787 | |
| transforming growth factor, beta receptor III | |
| 300 kDa transforming growth factor, beta receptor III | |
| 1110036H20 | |
| 300 kDa transforming growth factor, beta receptor 3 | |
| betaglycan, 300kD | |
| betaglycan, TGF-beta type III receptor | |
| betaglycan, TGF-beta type III receptors | |
| LOC128010 | |
| Tgfbr3s | |
| expressed sequence AU015626 | |
| TGF-beta receptor type III precursor | |
| transforming growth factor beta-3 receptor precursor | |
| transforming growth factor, beta receptor III (betaglycan, 300kDa) | |
| transforming growth factor, beta receptor III (betaglycan, 300kD) |
| Mouse chromosome position | 5 |
|---|---|
| 5 E5 |
| OMIM ID | 600742 |
|---|
| Rat chromosome position | 14p22 |
|---|
| Hugo ID | 11774 |
|---|
| Human chromosome position | 1p33-p32 |
|---|
| Swiss-Prot Accession | Q03167 |
|---|---|
| O88393 | |
| Q3TM82 | |
| P26342 | |
| A0AUW8 | |
| A8K5N0 | |
| B9EG88 | |
| Q5T2T4 | |
| Q5U731 | |
| Q9UGI2 | |
| Q6NS72 |
| PIR ID | A41220 |
|---|---|
| JC1350 |
| Unigene ID | Hs.482390 |
|---|---|
| Hs.735919 | |
| Mm.200775 | |
| Rn.9953 |
| KEGG ID | hsa:7049 |
|---|---|
| mmu:21814 | |
| rno:29610 |
| Swiss-Prot ID | TGBR3_RAT |
|---|---|
| TGBR3_HUMAN | |
| TGBR3_MOUSE |
| Ensembl ID | ENSG00000069702 |
|---|---|
| ENSP00000212355 | |
| ENST00000212355 | |
| ENSMUSG00000029287 | |
| ENSMUSP00000031224 | |
| ENSMUST00000031224 | |
| ENSRNOG00000002093 | |
| ENSRNOP00000002867 | |
| ENSRNOT00000002867 |
| Homologene ID | 2436 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 104637 |
|---|
| RGD ID | 61821 |
|---|
| MedScan ID | 7049 |
|---|