| URN | urn:agi-llid:4243 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1360 |
| Name | TGFBR2 |
| Description | transforming growth factor, beta receptor II |
| Notes | receptor for TGF-beta; may play a role in lung maturation and response to hypoxia [RGD] |
| GO Molecular Function | receptor signaling protein serine-threonine kinase activity |
|---|---|
| transmembrane receptor protein serine-threonine kinase activity | |
| transforming growth factor beta-activated receptor activity | |
| transforming growth factor beta receptor activity, type II | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| receptor activity | |
| SMAD binding | |
| type I transforming growth factor beta receptor binding | |
| type III transforming growth factor beta receptor binding | |
| mitogen-activated protein kinase kinase kinase binding | |
| transforming growth factor beta binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| glycosaminoglycan binding | |
| metal ion binding |
| GO Cellular Component | membrane |
|---|---|
| membrane raft | |
| integral component of membrane | |
| external side of plasma membrane | |
| integral component of plasma membrane | |
| transforming growth factor beta receptor homodimeric complex | |
| caveola | |
| receptor complex | |
| cell surface | |
| plasma membrane | |
| cytoplasm | |
| cytosol |
| GO Biological Process | embryo implantation |
|---|---|
| positive regulation of B cell tolerance induction | |
| positive regulation of T cell tolerance induction | |
| positive regulation of tolerance induction to self antigen | |
| embryonic hemopoiesis | |
| positive regulation of NK T cell differentiation | |
| myeloid dendritic cell differentiation | |
| patterning of blood vessels | |
| negative regulation of cardiac muscle cell proliferation | |
| embryo development | |
| cartilage development | |
| embryonic cranial skeleton morphogenesis | |
| blood vessel development | |
| vasculogenesis | |
| bronchus development | |
| brain development | |
| lung development | |
| organ morphogenesis | |
| organ regeneration | |
| heart development | |
| lens development in camera-type eye | |
| bronchus morphogenesis | |
| lung morphogenesis | |
| trachea morphogenesis | |
| trachea formation | |
| lung lobe morphogenesis | |
| mammary gland morphogenesis | |
| digestive tract development | |
| positive regulation of skeletal muscle tissue regeneration | |
| in utero embryonic development | |
| gastrulation | |
| positive regulation of epithelial cell migration | |
| aging | |
| cell differentiation | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| smoothened signaling pathway | |
| transmembrane receptor protein serine-threonine kinase signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| common-partner SMAD protein phosphorylation | |
| pathway-restricted SMAD protein phosphorylation | |
| apoptotic process | |
| lens fiber cell apoptotic process | |
| positive regulation of cell proliferation | |
| negative regulation of cell proliferation | |
| regulation of cell proliferation | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of mesenchymal cell proliferation | |
| response to drug | |
| response to organic substance | |
| response to nutrient | |
| response to glucose | |
| response to cholesterol | |
| response to organic cyclic compound | |
| response to steroid hormone | |
| response to estrogen | |
| response to hypoxia | |
| wound healing | |
| response to mechanical stimulus | |
| positive regulation of reactive oxygen species metabolic process | |
| activation of protein kinase activity | |
| regulation of growth | |
| palate development | |
| protein phosphorylation | |
| peptidyl-threonine phosphorylation | |
| peptidyl-serine phosphorylation | |
| phosphorylation | |
| receptor-mediated endocytosis |
| Pathway | Cell Cycle |
|---|---|
| Prostate Cancer Overview | |
| Metastatic Colorectal Cancer Overview | |
| Proteins Involved in Pathogenesis of T-cell Acute Lymphoblastic Leukemia | |
| Chronic Myeloid Leukemia Overview | |
| Hodgkin Lymphoma Overview | |
| Diffuse Large-B-cell Lymphoma Overview | |
| Proteins Involved in Pathogenesis of Prostate Cancer | |
| Activation of Immunoglobulin Class-Switch Recombination | |
| Regulatory T-cell Differentiation | |
| Cancer Overview | |
| Mechanisms of Cardiomyocyte Hypertrophy in Hypertrophic Cardiomyopathy | |
| Hypertrophic Cardiomyopathy Overview | |
| Impairment of BMP and TGF-beta Signaling in Familial and Idiopathic Pulmonary Arterial Hypertension | |
| Proteins Involved in Pathogenesis of Pulmonary Hypertension | |
| Impaired TGFB2 Signaling in Osteoarthritis | |
| Osteoarthritis Overview | |
| Steroid-Induced Cataract | |
| TGFBR Signaling in Pancreatic Cancer | |
| Pancreatic Ductal Carcinoma | |
| Proteins Involved in Pathogenesis of Pancreatic Cancer | |
| Pancreatic Neuroendocrine Tumors | |
| Impaired Osteoblast Function in Gout | |
| Epilepsies Associated with Blood-Brain Barrier Disruption | |
| Model Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma Fibroblasts 1 | |
| Mechanism of Skin Fibrosis in Systemic Scleroderma | |
| TGFBR -> ATF/GADD/MAX/TP53 signaling | |
| TGFBR -> CREB/ELK-SRF signaling | |
| TGFBR -> MEF/MYOD/MYOG signaling | |
| TGFBR -> SMAD1/5/9 signaling | |
| TGFBR -> AP-1 signaling | |
| TGFBR/BMPR -> SMAD2/3 signaling | |
| Ethanol-Induced Hepatotoxicity | |
| TGFB3-TGFBR2 Expression Targets | |
| TGFB2-TGFBR2 Expression Targets | |
| TGFB1-TGFBR2 Expression Targets | |
| BMP2-BMPR2 Expression Targets | |
| TGFB2-TGFBR1 Expression Targets | |
| TGFB3-TGFBR1 Expression Targets | |
| TNF/TP53/ATF Expression Targets | |
| IFNG-IFNR Expression Targets | |
| Leptin/ELK-SRF Expression Targets | |
| Leptin/STAT Expression Targets | |
| Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| Insulin/STAT Expression Targets | |
| TGFB1-TGFBR1 Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/STAT Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| TGFB1-ACVRL1 Expression Targets | |
| TGFB1-TGFBR1/AP-1 Expression Targets | |
| TNF/AP-1 Expression Targets | |
| IL1B Expression Targets | |
| EGF/CTNN Expression Targets | |
| transforming growth factor-beta Smad dependent signaling pathway | |
| colorectal cancer pathway | |
| pancreatic cancer pathway | |
| transforming growth factor-beta Smad dependent signaling pathway | |
| colorectal cancer pathway | |
| altered transforming growth factor-beta Smad dependent signaling pathway | |
| transforming growth factor-beta Smad dependent signaling pathway |
| Group | TGFBR |
|---|---|
| Tumor suppressors | |
| embryo implantation | |
| positive regulation of B cell tolerance induction | |
| positive regulation of T cell tolerance induction | |
| positive regulation of tolerance induction to self antigen | |
| embryonic hemopoiesis | |
| positive regulation of NK T cell differentiation | |
| myeloid dendritic cell differentiation | |
| receptor signaling protein serine-threonine kinase activity | |
| patterning of blood vessels | |
| negative regulation of cardiac muscle cell proliferation | |
| embryo development | |
| cartilage development | |
| embryonic cranial skeleton morphogenesis | |
| blood vessel development | |
| vasculogenesis | |
| bronchus development | |
| brain development | |
| lung development | |
| organ morphogenesis | |
| organ regeneration | |
| heart development | |
| lens development in camera-type eye | |
| bronchus morphogenesis | |
| lung morphogenesis | |
| trachea morphogenesis | |
| trachea formation | |
| lung lobe morphogenesis | |
| mammary gland morphogenesis | |
| digestive tract development | |
| positive regulation of skeletal muscle tissue regeneration | |
| in utero embryonic development | |
| gastrulation | |
| positive regulation of epithelial cell migration | |
| aging | |
| cell differentiation | |
| transmembrane receptor protein serine-threonine kinase activity | |
| transforming growth factor beta-activated receptor activity | |
| transforming growth factor beta receptor activity, type II | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| smoothened signaling pathway | |
| transmembrane receptor protein serine-threonine kinase signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| common-partner SMAD protein phosphorylation | |
| pathway-restricted SMAD protein phosphorylation | |
| apoptotic process | |
| lens fiber cell apoptotic process | |
| positive regulation of cell proliferation | |
| negative regulation of cell proliferation | |
| regulation of cell proliferation | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of mesenchymal cell proliferation | |
| response to drug | |
| response to organic substance | |
| response to nutrient | |
| response to glucose | |
| response to cholesterol | |
| response to organic cyclic compound | |
| response to steroid hormone | |
| response to estrogen | |
| response to hypoxia | |
| wound healing | |
| response to mechanical stimulus | |
| positive regulation of reactive oxygen species metabolic process | |
| activation of protein kinase activity | |
| regulation of growth | |
| palate development | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein phosphorylation | |
| peptidyl-threonine phosphorylation | |
| peptidyl-serine phosphorylation | |
| phosphorylation | |
| receptor-mediated endocytosis | |
| receptor activity | |
| SMAD binding | |
| type I transforming growth factor beta receptor binding | |
| type III transforming growth factor beta receptor binding | |
| mitogen-activated protein kinase kinase kinase binding | |
| transforming growth factor beta binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| glycosaminoglycan binding | |
| metal ion binding | |
| membrane | |
| membrane raft | |
| integral component of membrane | |
| external side of plasma membrane | |
| integral component of plasma membrane | |
| transforming growth factor beta receptor homodimeric complex | |
| caveola | |
| receptor complex | |
| cell surface | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| Genes with Mutations Associated with Pancreatic Cancer | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|
| LocusLink ID | 4243 |
|---|---|
| 7048 | |
| 21813 | |
| 81810 | |
| 76304 | |
| 102696 |
| Cell Localization | Plasma membrane |
|---|---|
| Cell membrane | |
| Membrane |
| GO ID | 0005524 |
|---|---|
| 0046332 | |
| 0005539 | |
| 0046872 | |
| 0031435 | |
| 0004702 | |
| 0050431 | |
| 0005026 | |
| 0005024 | |
| 0004675 | |
| 0034713 | |
| 0034714 | |
| 0032147 | |
| 0007568 | |
| 0006915 | |
| 0001568 | |
| 0007420 | |
| 0060434 | |
| 0051216 | |
| 0007182 | |
| 0048565 | |
| 0007566 | |
| 0048701 | |
| 0035162 | |
| 0007369 | |
| 0007507 | |
| 0001701 | |
| 0002088 | |
| 0060463 | |
| 0060443 | |
| 0043011 | |
| 0060044 | |
| 0030512 | |
| 0031100 | |
| 0060021 | |
| 0060389 | |
| 0001569 | |
| 0018105 | |
| 0018107 | |
| 0002663 | |
| 0051138 | |
| 0002666 | |
| 0008284 | |
| 0010634 | |
| 0002053 | |
| 2000379 | |
| 0043415 | |
| 0048661 | |
| 0002651 | |
| 0006468 | |
| 0006898 | |
| 0042127 | |
| 0070723 | |
| 0042493 | |
| 0043627 | |
| 0009749 | |
| 0009612 | |
| 0007584 | |
| 0007224 | |
| 0060440 | |
| 0007179 | |
| 0001570 | |
| 0042060 | |
| 0005901 | |
| 0005829 | |
| 0009897 | |
| 0016021 | |
| 0005886 | |
| 0043235 | |
| 0070022 | |
| 0016301 | |
| 0000166 | |
| 0004672 | |
| 0004674 | |
| 0004872 | |
| 0016740 | |
| 0016772 | |
| 0060433 | |
| 0030154 | |
| 1990086 | |
| 0030324 | |
| 0060425 | |
| 0008285 | |
| 0009887 | |
| 0016310 | |
| 0040008 | |
| 0060439 | |
| 0007178 | |
| 0009986 | |
| 0005737 | |
| 0005887 | |
| 0016020 | |
| 0045121 | |
| 0046982 | |
| 0042803 | |
| 0009790 | |
| 0001666 | |
| 0014070 | |
| 0010033 | |
| 0048545 | |
| 0023014 | |
| 0000287 | |
| 0030145 | |
| 0005515 | |
| 0006470 | |
| 0004682 | |
| 0045165 | |
| 0004713 | |
| 0004691 |
| Alias | AAT3 |
|---|---|
| FAA3 | |
| MFS2 | |
| RIIC | |
| LDS1B | |
| LDS2B | |
| TAAD2 | |
| TGFR-2 | |
| TGFbeta-RII | |
| TGF-beta receptor type-2 | |
| tbetaR-II | |
| TGF-beta type II receptor | |
| TGF-beta receptor type IIB | |
| transforming growth factor beta receptor type IIC | |
| DNIIR | |
| RIIDN | |
| TBR-II | |
| AU042018 | |
| TbetaRII | |
| 1110020H15Rik | |
| TGF-beta receptor II | |
| TGF-beta receptor type II | |
| transforming growth factor-beta receptor type II | |
| Tgfbr2T | |
| TGF-beta 2 | |
| transforming growth factor beta, receptor 2 | |
| transforming growth factor, beta receptor 2 | |
| transforming growth factor, beta receptor IIT | |
| transforming growth factor-b type II receptor | |
| transforming growth factor beta receptor type II | |
| transforming growth factor-beta type II receptor | |
| transforming growth factor, beta receptor II | |
| TGR2_HUMAN | |
| transforming growth factor beta (TGF-beta) receptor type II | |
| TGF-beta-RII | |
| TGR2 | |
| TGFR IIs | |
| Tgfbr2 | |
| transforming growth factor, beta receptor II (70/80kDa) | |
| TGFR II | |
| transforming growth factor, beta receptor II (70-80kD) | |
| RIKEN cDNA 1110020H15 gene | |
| transforming growth factor-b type II receptors | |
| Transforming Growth Factor-beta R II | |
| Transforming Growth Factor-beta RII | |
| type II transforming growth factor-beta receptor | |
| type II transforming growth factor-beta receptors | |
| Marfan syndrome 2 gene | |
| TGFbetaRII | |
| transforming growth factor, beta receptor II (70/80kDa) isoform 2 | |
| HNPCC6 | |
| TGFbetaR2 | |
| 1110020H15 | |
| 70-80 kDa transforming growth factor, beta receptor II | |
| aortic aneurysm, familial thoracic 3 | |
| 70-80 kDa transforming growth factor, beta receptor 2 | |
| T beta RII | |
| TGF-beta-R II | |
| TGF-beta II receptors | |
| TGF beta R2 | |
| T beta R-II | |
| transforming growth factor, beta receptor II (70/80kDa) isoform 1 | |
| Marfan syndrome 2 | |
| Marfan syndrome II | |
| TGF-beta type II receptor | |
| TGF-beta receptor type II precursor | |
| Tgfbr2s | |
| HNPCC6s | |
| transforming growth factor beta receptor 2 |
| Mouse chromosome position | 9 68.39 cM |
|---|---|
| 9 69.0 cM |
| OMIM ID | 190182 |
|---|---|
| 614331 | |
| 610168 | |
| 610380 | |
| 133239 | |
| 609192 | |
| 154705 | |
| 608967 |
| Rat chromosome position | 8q32 |
|---|
| Hugo ID | 11773 |
|---|
| Human chromosome position | 3p22 |
|---|
| Swiss-Prot Accession | D2JYI1 |
|---|---|
| P37173 | |
| A3QNQ0 | |
| Q543C0 | |
| Q62312 | |
| Q8BQS9 | |
| Q3UG22 | |
| P38438 | |
| Q63947 | |
| B4DTV5 | |
| Q15580 | |
| Q6DKT6 | |
| Q99474 | |
| Q6A176 | |
| Q78JJ8 | |
| Q8BRS2 | |
| Q91ZR8 | |
| Q9JLZ4 | |
| Q8R4G7 | |
| Q8IWC9 |
| PIR ID | S51371 |
|---|---|
| A42100 | |
| JN0459 |
| Unigene ID | Hs.82028 |
|---|---|
| Hs.604277 | |
| Mm.172346 | |
| Rn.9954 |
| KEGG ID | hsa:7048 |
|---|---|
| mmu:21813 | |
| rno:81810 |
| Swiss-Prot ID | TGFR2_MOUSE |
|---|---|
| TGFR2_HUMAN | |
| TGFR2_RAT | |
| A3QNQ0_HUMAN | |
| Q3UG22_MOUSE | |
| D2JYI1_HUMAN | |
| Q543C0_MOUSE | |
| Q8BQS9_MOUSE | |
| B4DTV5_HUMAN | |
| Q91ZR8_MOUSE |
| EC Number | 2.7.11.30 |
|---|---|
| 2.7.11.1 |
| Ensembl ID | ENSG00000163513 |
|---|---|
| ENSP00000351905 | |
| ENST00000359013 | |
| ENSP00000295754 | |
| ENST00000295754 | |
| ENSMUSG00000032440 | |
| ENSMUSP00000062333 | |
| ENSMUST00000061101 | |
| ENSMUSP00000035014 | |
| ENSMUST00000035014 | |
| ENSRNOG00000013265 | |
| ENSRNOP00000035501 | |
| ENSRNOT00000037883 |
| Homologene ID | 2435 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 98729 |
|---|---|
| 1923554 | |
| 2143233 |
| RGD ID | 69651 |
|---|
| MedScan ID | 4243 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|
| IPI ID | IPI00020431 |
|---|---|
| IPI00164934 | |
| IPI00327360 | |
| IPI00124569 | |
| IPI00227844 | |
| IPI00465333 | |
| IPI00462968 | |
| IPI00564837 |
| KEGG pathway | Cytokine-cytokine receptor interaction |
|---|---|
| MAPK signaling pathway | |
| TGF-beta signaling pathway | |
| Adherens junction |