| URN | urn:agi-llid:7046 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1182 |
| Name | TGFBR1 |
| Description | transforming growth factor, beta receptor 1 |
| Notes | forms a heteromeric receptor complex with TGF-beta type II receptor that binds TGF-beta and mediates TGF-beta signalling [RGD] |
| GO Molecular Function | transmembrane receptor protein serine-threonine kinase activity |
|---|---|
| transforming growth factor beta-activated receptor activity | |
| transforming growth factor beta receptor activity, type I | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein complex binding | |
| SMAD binding | |
| growth factor binding | |
| type II transforming growth factor beta receptor binding | |
| ubiquitin protein ligase binding | |
| transforming growth factor beta binding | |
| protein heterodimerization activity | |
| I-SMAD binding | |
| nucleotide binding | |
| ATP binding | |
| metal ion binding |
| GO Cellular Component | membrane |
|---|---|
| cell junction | |
| membrane raft | |
| integral component of membrane | |
| transforming growth factor beta receptor homodimeric complex | |
| caveola | |
| apical plasma membrane | |
| basolateral plasma membrane | |
| protein complex | |
| receptor complex | |
| plasma membrane | |
| tight junction |
| GO Biological Process | germ cell migration |
|---|---|
| embryo implantation | |
| thymus development | |
| activation of MAPKK activity | |
| post-embryonic development | |
| anterior-posterior pattern specification | |
| embryo development | |
| skeletal system development | |
| pharyngeal system development | |
| skeletal system morphogenesis | |
| embryonic cranial skeleton morphogenesis | |
| negative regulation of chondrocyte differentiation | |
| angiogenesis | |
| artery morphogenesis | |
| kidney development | |
| lung development | |
| organ regeneration | |
| heart development | |
| lens development in camera-type eye | |
| mesenchymal cell differentiation | |
| epithelial to mesenchymal transition | |
| parathyroid gland development | |
| neuron fate commitment | |
| digestive tract development | |
| negative regulation of endothelial cell differentiation | |
| in utero embryonic development | |
| blastocyst development | |
| endothelial cell migration | |
| aging | |
| cell differentiation | |
| extracellular structure organization | |
| cell cycle arrest | |
| signal transduction | |
| positive regulation of protein kinase B signaling | |
| positive regulation of apoptotic signaling pathway | |
| negative regulation of extrinsic apoptotic signaling pathway | |
| positive regulation of SMAD protein import into nucleus | |
| positive regulation of pathway-restricted SMAD protein phosphorylation | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| transmembrane receptor protein serine-threonine kinase signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| pathway-restricted SMAD protein phosphorylation | |
| positive regulation of cell growth | |
| cell motility | |
| positive regulation of cellular component movement | |
| apoptotic process | |
| negative regulation of apoptotic process | |
| positive regulation of filopodium assembly | |
| collagen fibril organization | |
| positive regulation of cell proliferation | |
| negative regulation of endothelial cell proliferation | |
| response to toxic substance | |
| response to cholesterol | |
| response to prostaglandin E | |
| cellular response to transforming growth factor beta stimulus | |
| response to organic cyclic compound | |
| response to estrogen | |
| response to hypoxia | |
| wound healing | |
| response to electrical stimulus | |
| positive regulation of transcription, DNA-templated | |
| regulation of growth | |
| regulation of protein ubiquitination | |
| regulation of transcription, DNA-templated | |
| regulation of gene expression | |
| palate development | |
| protein phosphorylation | |
| peptidyl-threonine phosphorylation | |
| peptidyl-serine phosphorylation | |
| protein autophosphorylation | |
| phosphorylation | |
| regulation of protein binding |
| Pathway | Cell Cycle |
|---|---|
| Transcytosis | |
| Prostate Cancer Overview | |
| Metastatic Colorectal Cancer Overview | |
| Role of Myostatin in Skeletal Muscles | |
| Myostatin-IGF1 Crosstalk in Skeletal Muscles | |
| Chronic Myeloid Leukemia Overview | |
| Th17 Cell Activation in Crohn's Disease | |
| Differentiation of Psoriatic T-cells | |
| Basal Breast Cancer | |
| Ovarian Cancer Overview | |
| Proteins Involved in Pathogenesis of Prostate Cancer | |
| Activation of Immunoglobulin Class-Switch Recombination | |
| Th17 Cell Differentiation | |
| Regulatory T-cell Differentiation | |
| Cancer Overview | |
| Mechanisms of Cardiomyocyte Hypertrophy in Hypertrophic Cardiomyopathy | |
| Hypertrophic Cardiomyopathy Overview | |
| Impairment of BMP and TGF-beta Signaling in Familial and Idiopathic Pulmonary Arterial Hypertension | |
| Proteins Involved in Pathogenesis of Pulmonary Hypertension | |
| Activation of Glioma Stem Cell Program | |
| Medulloblastoma Overview | |
| Reduction of Th17 cell Numbers in HIV Type 1 Infection | |
| Impaired TGFB2 Signaling in Osteoarthritis | |
| Osteoarthritis Overview | |
| TGFBR Signaling in Pancreatic Cancer | |
| Pancreatic Ductal Carcinoma | |
| Proteins Involved in Pathogenesis of Pancreatic Cancer | |
| Pancreatic Neuroendocrine Tumors | |
| Growth Factor Signaling in Hepatocellular Carcinoma | |
| Proteins Involved in Pathogenesis of Hepatocellular Carcinoma | |
| Hepatocellular Carcinoma Overview | |
| Impaired Osteoblast Function in Gout | |
| Epilepsies Associated with Blood-Brain Barrier Disruption | |
| Model Autocrine Cytokine/Chemokine Loops in Systemic Scleroderma Fibroblasts 1 | |
| Mechanism of Skin Fibrosis in Systemic Scleroderma | |
| TGFBR -> ATF/GADD/MAX/TP53 signaling | |
| TGFBR -> CREB/ELK-SRF signaling | |
| TGFBR -> MEF/MYOD/MYOG signaling | |
| TGFBR -> AP-1 signaling | |
| TGFBR/BMPR -> SMAD2/3 signaling | |
| Dexamethasone-Induced Osteoporosis | |
| TGFB2-TGFBR1 Expression Targets | |
| TGFB3-TGFBR1 Expression Targets | |
| TGFB1-TGFBR1 Expression Targets | |
| TGFB1-TGFBR1/AP-1 Expression Targets | |
| transforming growth factor-beta Smad dependent signaling pathway | |
| colorectal cancer pathway | |
| transforming growth factor-beta Smad dependent signaling pathway | |
| colorectal cancer pathway | |
| altered transforming growth factor-beta Smad dependent signaling pathway | |
| transforming growth factor-beta Smad dependent signaling pathway |
| Group | TGFBR |
|---|---|
| germ cell migration | |
| embryo implantation | |
| thymus development | |
| activation of MAPKK activity | |
| post-embryonic development | |
| anterior-posterior pattern specification | |
| embryo development | |
| skeletal system development | |
| pharyngeal system development | |
| skeletal system morphogenesis | |
| embryonic cranial skeleton morphogenesis | |
| negative regulation of chondrocyte differentiation | |
| angiogenesis | |
| artery morphogenesis | |
| kidney development | |
| lung development | |
| organ regeneration | |
| heart development | |
| lens development in camera-type eye | |
| mesenchymal cell differentiation | |
| epithelial to mesenchymal transition | |
| parathyroid gland development | |
| neuron fate commitment | |
| digestive tract development | |
| negative regulation of endothelial cell differentiation | |
| in utero embryonic development | |
| blastocyst development | |
| endothelial cell migration | |
| aging | |
| cell differentiation | |
| extracellular structure organization | |
| cell cycle arrest | |
| signal transduction | |
| positive regulation of protein kinase B signaling | |
| transmembrane receptor protein serine-threonine kinase activity | |
| transforming growth factor beta-activated receptor activity | |
| transforming growth factor beta receptor activity, type I | |
| positive regulation of apoptotic signaling pathway | |
| negative regulation of extrinsic apoptotic signaling pathway | |
| positive regulation of SMAD protein import into nucleus | |
| positive regulation of pathway-restricted SMAD protein phosphorylation | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| transmembrane receptor protein serine-threonine kinase signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| pathway-restricted SMAD protein phosphorylation | |
| positive regulation of cell growth | |
| cell motility | |
| positive regulation of cellular component movement | |
| apoptotic process | |
| negative regulation of apoptotic process | |
| positive regulation of filopodium assembly | |
| collagen fibril organization | |
| positive regulation of cell proliferation | |
| negative regulation of endothelial cell proliferation | |
| response to toxic substance | |
| response to cholesterol | |
| response to prostaglandin E | |
| cellular response to transforming growth factor beta stimulus | |
| response to organic cyclic compound | |
| response to estrogen | |
| response to hypoxia | |
| wound healing | |
| response to electrical stimulus | |
| positive regulation of transcription, DNA-templated | |
| regulation of growth | |
| regulation of protein ubiquitination | |
| regulation of transcription, DNA-templated | |
| regulation of gene expression | |
| palate development | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein phosphorylation | |
| peptidyl-threonine phosphorylation | |
| peptidyl-serine phosphorylation | |
| protein autophosphorylation | |
| phosphorylation | |
| regulation of protein binding | |
| protein complex binding | |
| SMAD binding | |
| growth factor binding | |
| type II transforming growth factor beta receptor binding | |
| ubiquitin protein ligase binding | |
| transforming growth factor beta binding | |
| protein heterodimerization activity | |
| I-SMAD binding | |
| nucleotide binding | |
| ATP binding | |
| metal ion binding | |
| membrane | |
| cell junction | |
| membrane raft | |
| integral component of membrane | |
| transforming growth factor beta receptor homodimeric complex | |
| caveola | |
| apical plasma membrane | |
| basolateral plasma membrane | |
| protein complex | |
| receptor complex | |
| plasma membrane | |
| tight junction | |
| Secreted proteins |
| Source | Curated |
|---|
| LocusLink ID | 7046 |
|---|---|
| 21812 | |
| 29591 | |
| 100276 |
| Cell Localization | Plasma membrane |
|---|---|
| Cell membrane | |
| Cell junction | |
| Tight junction | |
| Membrane |
| GO ID | 0005524 |
|---|---|
| 0070411 | |
| 0046332 | |
| 0019838 | |
| 0046872 | |
| 0004672 | |
| 0004674 | |
| 0050431 | |
| 0005025 | |
| 0005024 | |
| 0004675 | |
| 0005114 | |
| 0000186 | |
| 0001525 | |
| 0009952 | |
| 0006915 | |
| 0048844 | |
| 0001824 | |
| 0007050 | |
| 0048870 | |
| 0071560 | |
| 0030199 | |
| 0048701 | |
| 0043542 | |
| 0001837 | |
| 0043062 | |
| 0008354 | |
| 0007507 | |
| 0001701 | |
| 0001822 | |
| 0002088 | |
| 0048762 | |
| 0043066 | |
| 0032331 | |
| 0001937 | |
| 2001237 | |
| 0030512 | |
| 0048663 | |
| 0060021 | |
| 0060017 | |
| 0060389 | |
| 0018105 | |
| 0018107 | |
| 0060037 | |
| 0060391 | |
| 2001235 | |
| 0030307 | |
| 0008284 | |
| 0051272 | |
| 0051491 | |
| 0010862 | |
| 0051897 | |
| 0045893 | |
| 0009791 | |
| 0006468 | |
| 0043393 | |
| 0031396 | |
| 0006355 | |
| 0070723 | |
| 0007165 | |
| 0001501 | |
| 0048705 | |
| 0048538 | |
| 0007179 | |
| 0042060 | |
| 0005886 | |
| 0043235 | |
| 0005923 | |
| 0070022 | |
| 0016301 | |
| 0000166 | |
| 0032403 | |
| 0046982 | |
| 0016740 | |
| 0016772 | |
| 0031625 | |
| 0030154 | |
| 0009790 | |
| 0045602 | |
| 0016310 | |
| 0046777 | |
| 0010468 | |
| 0040008 | |
| 0043627 | |
| 0007178 | |
| 0016324 | |
| 0016323 | |
| 0005901 | |
| 0030054 | |
| 0016021 | |
| 0016020 | |
| 0045121 | |
| 0043234 | |
| 0007568 | |
| 0048565 | |
| 0007566 | |
| 0030324 | |
| 0031100 | |
| 0051602 | |
| 0001666 | |
| 0014070 | |
| 0034695 | |
| 0009636 | |
| 0006917 | |
| 0042981 | |
| 0044459 | |
| 0045885 | |
| 0004872 | |
| 0045941 | |
| 0045449 | |
| 0000287 | |
| 0030145 | |
| 0043130 | |
| 0005515 | |
| 0007181 | |
| 0005887 | |
| 0004702 | |
| 0005615 | |
| 0004682 | |
| 0007160 | |
| 0004713 | |
| 0004691 |
| Alias | AAT5 |
|---|---|
| ALK5 | |
| MSSE | |
| SKR4 | |
| ALK-5 | |
| LDS1A | |
| LDS2A | |
| TGFR-1 | |
| ACVRLK4 | |
| RP11-96L7.1 | |
| TGF-beta receptor type-1 | |
| tbetaR-I | |
| TGF-beta receptor type I | |
| TGF-beta type I receptor | |
| activin receptor-like kinase 5 | |
| transforming growth factor beta receptor I | |
| serine/threonine-protein kinase receptor R4 | |
| activin A receptor type II-like kinase, 53kD | |
| activin A receptor type II-like kinase, 53kDa | |
| transforming growth factor-beta receptor type I | |
| activin A receptor type II-like protein kinase of 53kD | |
| transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD) | |
| TbetaRI | |
| AU017191 | |
| RP23-457P12.1 | |
| ESK2 | |
| transforming growth factor, beta receptor I | |
| Tgfbr1 | |
| TGR1 | |
| TGF-beta I receptors | |
| tgf-beta 1 receptors | |
| TGF-beta RI | |
| TGF-beta type I and activin receptor | |
| TGF-beta type I and activin receptors | |
| Tgfbr I | |
| TGF-beta R I | |
| TGFR I | |
| TGR I | |
| transforming growth factor beta (TGF-beta) receptor type I | |
| transforming growth factor, beta receptor 1 | |
| Transforming Growth Factor-beta R I | |
| Transforming Growth Factor-beta RI | |
| type I transforming growth factor-beta receptor | |
| TGF-beta 1 receptor | |
| TGR1_HUMAN | |
| type I transforming growth factor-beta receptors | |
| activin A receptor type II-like kinase | |
| Activin receptor-like kinase V | |
| LOC666236 | |
| T beta R-I | |
| ALK V | |
| T beta RI | |
| LOC669553 | |
| MGC93659 | |
| LOC674605 | |
| OTTHUMP00000021783 | |
| OTTMUSP00000007205 | |
| OTTMUSP00000007207 | |
| TGF-beta type I receptor | |
| TGF-beta receptor type I precursor | |
| Tgfbr1s | |
| expressed sequence AU017191 | |
| Tgfbr Is |
| Mouse chromosome position | 4 26.02 cM |
|---|---|
| 4 19.3 cM |
| OMIM ID | 190181 |
|---|---|
| 609192 | |
| 608967 | |
| 132800 | |
| 609129 | |
| 610168 |
| Rat chromosome position | 5q22 |
|---|
| Hugo ID | 11772 |
|---|
| Human chromosome position | 9q22 |
|---|
| Swiss-Prot Accession | P36897 |
|---|---|
| Q5T7S2 | |
| Q4FJL1 | |
| Q64729 | |
| Q5M9H3 | |
| P80204 | |
| A2AJN0 | |
| Q6IR47 | |
| Q706C0 | |
| Q706C1 | |
| Q3U485 | |
| Q9CVP4 | |
| Q9D5H8 |
| PIR ID | JC2061 |
|---|---|
| JC2062 | |
| A49432 |
| Unigene ID | Hs.494622 |
|---|---|
| Mm.197552 | |
| Rn.44402 |
| KEGG ID | hsa:7046 |
|---|---|
| mmu:21812 | |
| rno:29591 |
| Swiss-Prot ID | TGFR1_MOUSE |
|---|---|
| TGFR1_HUMAN | |
| Q6IR47_HUMAN | |
| Q5M9H3_RAT | |
| Q5T7S2_HUMAN | |
| Q4FJL1_MOUSE |
| EC Number | 2.7.11.30 |
|---|---|
| 2.7.11.1 | |
| 2.7.1.37 |
| Ensembl ID | ENSG00000106799 |
|---|---|
| ENSP00000364129 | |
| ENST00000374990 | |
| ENSP00000364133 | |
| ENST00000374994 | |
| ENSP00000447297 | |
| ENST00000552516 | |
| ENSMUSG00000007613 | |
| ENSMUSP00000007757 | |
| ENSMUST00000007757 | |
| ENSRNOG00000007036 | |
| ENSRNOP00000009452 | |
| ENSRNOT00000009452 |
| Homologene ID | 3177 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 98728 |
|---|---|
| 2140434 |
| RGD ID | 3852 |
|---|
| MedScan ID | 7046 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|
| IPI ID | IPI00005733 |
|---|---|
| IPI00844074 | |
| IPI01018344 | |
| IPI00137994 | |
| IPI00649475 | |
| IPI00195461 | |
| IPI00808091 | |
| IPI00808549 | |
| IPI00107992 | |
| IPI00777873 |
| KEGG pathway | Cytokine-cytokine receptor interaction |
|---|---|
| MAPK signaling pathway | |
| TGF-beta signaling pathway | |
| Adherens junction |